本文選題：腫瘤 + SHD　； 參考：《科技導(dǎo)報(bào)》2015年02期

【摘要】：為了對(duì)SH2D7基因序列及其編碼蛋白進(jìn)行生物信息學(xué)分析,應(yīng)用NCBI數(shù)據(jù)庫(kù)和Ex PASy等程序,對(duì)SH2D7基因核苷酸序列進(jìn)行了分析,并預(yù)測(cè)了其編碼蛋白的理化性質(zhì)及二級(jí)結(jié)構(gòu)等。結(jié)果表明,SH2D7基因定位于人類染色體15q25.1,包含了6個(gè)外顯子和5個(gè)內(nèi)含子。SH2D7基因編碼蛋白的功能主要涉及基因表達(dá)調(diào)控、信號(hào)傳導(dǎo)等;分子量約為49.8 k D,等電點(diǎn)為5.99,是一種親水蛋白,主要位于細(xì)胞核中,有35個(gè)磷酸化位點(diǎn)及22個(gè)抗原位點(diǎn)。
[Abstract]:In order to bioinformatic analysis of SH2D7 gene sequence and its coded protein , the nucleotide sequence of SH2D7 gene was analyzed and the physicochemical properties and secondary structure of SH2D7 gene were predicted . The results showed that SH2D7 gene was located in human chromosome 15q25 . 1 . The function of SH2D7 gene was mainly involved in gene expression regulation , signal transduction , etc . The molecular weight was 49.8 k D , isoelectric point was 5.99 , it was a kind of hydrophilic protein , mainly in nucleus , 35 phosphorylation sites and 22 antigenic sites .

【作者單位】： 寧夏醫(yī)科大學(xué)檢驗(yàn)學(xué)院;寧夏檢驗(yàn)醫(yī)學(xué)研究所;
【基金】：寧夏自然科學(xué)基金項(xiàng)目(NZ11135)
【分類號(hào)】：Q811.4

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