本文選題：生物材料 + 磷酰膽堿��； 參考：《南京師范大學(xué)》2012年碩士論文

【摘要】：新型抗凝血材料的合成和性能研究具有重大的應(yīng)用價值和科學(xué)意義,是目前生物醫(yī)用材料的熱點研究領(lǐng)域之一。其中,在高分子材料上修飾磷酰膽堿結(jié)構(gòu)的物質(zhì)是有效提高材料抗凝血性的重要途徑之一。磷酰膽堿結(jié)構(gòu)修飾的高分子材料主要有兩種類型,一類是磷酰膽堿修飾在高聚物的側(cè)鏈上,另一類是磷酰膽堿結(jié)構(gòu)在主鏈上。磷酰膽堿有效基團在主鏈上的聚合物由于具有與生物大分子更相似的聚電解質(zhì)鏈結(jié)構(gòu)和自組裝形式,一直是人們關(guān)注的焦點,作為藥物載體和植入材料在生物醫(yī)藥領(lǐng)域具有廣泛的應(yīng)用前景。在本論文中,我們成功合成了主鏈上含有磷酰膽堿結(jié)構(gòu)的聚氨酯(PCPU),并利用紅外、核磁等手段對其化學(xué)結(jié)構(gòu)進行了精確表征。我們對制備得到的聚氨酯-磷酰膽堿聚氨酯(PU-PCPU)的復(fù)合膜材料進行了力學(xué)性能(拉伸應(yīng)力和楊氏模量)和生物學(xué)性能(血小板粘附和溶血)的評估,證明其有望用于抗凝血材料的實際臨床應(yīng)用。同時,我們利用介電譜表征了固體膜和膜-水體系的介電性能。固體膜的介電測試結(jié)果表明由于偶極離子的凝聚使得PCPU的軟段剛性增強,成功解釋了復(fù)合膜楊氏模量的增強的結(jié)構(gòu)原因。而膜-水體系的介電測試提供了一種原位表征材料表面性能的新方法,定量描述了膜表面的界面動力學(xué),并由此提出關(guān)于血液或生物相容性機理的新假想,即含有兩性離子結(jié)構(gòu)的親水性表面具有良好生物(血液)相容性是基于其對外界電磁刺激的響應(yīng)特征。
[Abstract]:The research on the synthesis and properties of new anticoagulant materials has great application value and scientific significance, and is one of the hot research fields of biomedical materials.Among them, modification of phosphatidylcholine structure on polymer materials is one of the important ways to improve anticoagulability.There are two main types of phosphorylcholine modified polymer, one is phosphorylcholine modified on the side chain of polymer, the other is phosphorylcholine structure on the main chain.Phosphorylcholine effective group polymers on the main chain have been the focus of attention due to their polyelectrolyte chain structure and self-assembly form, which are more similar to biological macromolecules.As a drug carrier and implant material, it has a wide application prospect in the field of biomedicine.In this thesis, we have successfully synthesized PCPU with phosphatidylcholine structure on the main chain and characterized its chemical structure by IR and NMR.The mechanical properties (tensile stress and Young's modulus) and biological properties (platelet adhesion and hemolysis) of the PU-PCPU composite membranes were evaluated.It is proved that it is expected to be used in clinical application of anticoagulant materials.At the same time, the dielectric properties of solid films and film-water systems were characterized by dielectric spectroscopy.The results of dielectric measurements show that the rigidity of the soft segment of PCPU is enhanced due to the condensation of dipole ions, which explains the structural reasons for the enhancement of the Young's modulus of the composite membrane.The dielectric measurement of membrane-water system provides a new method for in situ characterization of the surface properties of the materials. The interfacial kinetics of the membrane surface is described quantitatively, and a new hypothesis about the mechanism of blood or biocompatibility is proposed.The hydrophilic surface with amphoteric ion structure has good biocompatibility based on its response to external electromagnetic stimulation.
【學(xué)位授予單位】：南京師范大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2012
【分類號】：R318.08

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