本文選題：超臨界溶液浸漬法　切入點(diǎn)：傷口敷料　出處：《高分子學(xué)報(bào)》2014年06期

【摘要】：利用超臨界溶液浸漬法(SSI)將磺胺嘧啶銀(AgSD)負(fù)載到不對(duì)稱殼聚糖膜(ACF)制備傷口敷料,研究了SSI過(guò)程操作壓力及溫度對(duì)載藥量的影響,并對(duì)AgSD-ACF的吸水量、水蒸氣滲透速率、體外釋放、抑菌性能和動(dòng)物皮膚傷口愈合行為進(jìn)行了考察.結(jié)果表明,AgSD-ACF的載藥量隨著CO2壓力的升高先增加后減少,而溫度對(duì)載藥量的影響較復(fù)雜,在20 MPa和50℃時(shí)載藥量達(dá)到最大為5.0 mg/g.AgSD-ACF的水蒸氣滲透速率和吸水量可通過(guò)改變ACF中致密層的厚度進(jìn)行調(diào)節(jié).AgSD-ACF具有緩釋作用,可持續(xù)釋放10 h以上,并且對(duì)金黃色葡萄球菌和綠膿桿菌均有較強(qiáng)的抑制作用.動(dòng)物試驗(yàn)顯示AgSD-ACF傷口敷料具有促進(jìn)大鼠皮膚傷口愈合的作用.
[Abstract]:The effect of operating pressure and temperature of SSI process on drug loading was studied by means of supercritical solution impregnation method (SSI), which loaded silver sulfadiazine (Ag SD) onto asymmetric chitosan membrane (ACF) to prepare wound dressing. The water absorption and vapor permeation rate of AgSD-ACF were also studied.In vitro release, bacteriostatic properties and wound healing behavior of animal skin were investigated.The results showed that the drug loading of AgSD-ACF increased first and then decreased with the increase of CO2 pressure, but the effect of temperature on the drug loading was more complex.At 20 MPa and 50 鈩，

本文編號(hào)：1727928