本文選題：腦電壓　切入點：EEG技術(shù)　出處：《廣西大學(xué)》2013年碩士論文

【摘要】：大腦是支配人的意識、思維、情感、運動和接受各種感覺的器官,其生理功能是通過生物電的活動來實現(xiàn)的。腦電壓是大腦神經(jīng)細(xì)胞電活動的重要表征。腦電圖EEG(Electroencephalogram)技術(shù)可以檢測到在沒有特定外界刺激或?qū)Ω杏X器官施加光、聲、電以及觸壓等不同刺激后所引起的腦電位變化,它很好地反映了大腦的電活動特性。癲癇病是嚴(yán)重威脅人類健康的疾病之一,該病發(fā)作的主要原因之一是強光刺激。忽然的閃光、眩目刺眼的光波都有可能導(dǎo)致癲癇病發(fā)作,使患者大腦神經(jīng)功能紊亂,腦電壓急劇變化以致產(chǎn)生尖銳棘波。目前還沒有一個有效治愈癲癇的方法,主要原因是對其發(fā)病機理尚不明確。所以了解和掌握外光刺激下人腦電壓的變化規(guī)律是非常重要的,它對人們更好地研究癲癇發(fā)病機理、預(yù)測和提高臨床治療效果具有重要的指導(dǎo)意義。 本文主要研究不同頻率、不同強度的外光刺激對人腦頭皮電壓變化的影響,掌握人腦電壓在不同頻率和強度外光刺激下的變化特性,并從理論上進(jìn)行機理探討。具體研究工作如下： 1.基于電磁場和神經(jīng)元電流偶極子等效理論,理論上計算和分析了外電流刺激和人腦頭皮電壓之間的變化關(guān)系。研究結(jié)果表明：在不同外電流刺激下,腦電壓變化大小與刺激電流頻率成反比,與刺激電流強度成正比。該結(jié)果為在不同頻率和強度外光刺激下人腦電壓變化特性的機理研究奠定必要的理論基礎(chǔ)。 2.基于EEG技術(shù),研究了不同強度的光刺激人眼對大腦頭皮腦電壓變化的影響。結(jié)果表明：用相同頻率但不同亮度的光照射人眼時,大腦頭皮電壓變化規(guī)律是不一樣的：光亮度越強,大腦頭皮電壓就越大,反之就越小。該結(jié)果為人們更好地研究腦電壓的光刺激幅度效應(yīng)提供有意義的實驗依據(jù)。 3.基于EEG技術(shù),研究了不同頻率(顏色)光刺激人眼對大腦頭皮電壓變化的影響。結(jié)果表明：在所研究的頻率范圍內(nèi),外光頻率越小,大腦頭皮電壓變化就越大,反之越小。 4.照射到人眼的光線被感光細(xì)胞接受,在其超極化過程中,光信號被轉(zhuǎn)化為電信號�；谏鲜鐾獯碳る娏鲗θ四X電壓的影響研究結(jié)果,對人腦頭皮電壓隨不同強度外光刺激的變化特性進(jìn)行了機理研究：外界強光刺激癲癇患者眼睛時引起大腦皮層的腦神經(jīng)細(xì)胞膜通過的電流幅度大大增加,使得大腦頭皮電壓急劇變大。光刺激越強,引起細(xì)胞膜的穿膜電流就越強,導(dǎo)致的腦電壓變化就越大。當(dāng)光強引起的穿膜電流超過一定閾值時,將引起一系列生理或生化副效應(yīng)而誘發(fā)癲癇產(chǎn)生。為進(jìn)一步研究腦神經(jīng)光刺激效應(yīng)、預(yù)防和治療癲癇等腦部疾病提供有意義的理論依據(jù)。 5.基于本文所推導(dǎo)的外刺激電流引起的大腦頭皮電壓變化計算模型,并根據(jù)不同頻率外光刺激和大腦頭皮電壓之間的變化關(guān)系,對頭皮電壓隨不同頻率外光刺激的變化特性進(jìn)行了機理探討：當(dāng)較小頻率的外光刺激人眼時,產(chǎn)生的大腦皮層的神經(jīng)元穿膜電流的頻率較低,細(xì)胞的放電時程較長,同時放電的神經(jīng)元數(shù)目比較多,因此測試到的頭皮電壓變化也較大。為進(jìn)一步研究神經(jīng)元光頻率特性提供有意義的理論依據(jù)。
[Abstract]:The brain is the dominate people's consciousness, thinking, emotion, movement and accept all kinds of sense organ, its physiological function is realized by bioelectrical activities. Brain voltage is an important representation of the electrical activity of nerve cells in the brain. EEG EEG (Electroencephalogram) technique can be detected in no particular external stimuli or sensory organs to Shi Jiaguang sound changes of brain potentials caused by electric contact pressure and different stimulation, it is good to reflect the characteristics of the electrical activity of the brain. Epilepsy is a serious threat to human health, the attack is one of the main causes of glare. Suddenly the flash, dazzling dazzling light waves are likely to lead to the patients with epileptic seizures, brain nerve function disorder, resulting in sharp sharp changes in brain voltage spikes. There is currently no effective cure method of epilepsy, the main reason is that the pathogenesis is still It is not clear. Therefore, it is very important to understand and master the change rule of human brain voltage under external light stimulation. It has important guiding significance for people to better study the pathogenesis of epilepsy, predict and improve the clinical treatment effect.
In this paper, we mainly studied the effect of different frequency and intensity of external light stimulation on the human brain scalp voltage. We studied the change characteristics of human brain voltage under different frequency and intensity under external light stimulation, and discussed the mechanism theoretically.
1. based on the electromagnetic field and equivalent current dipole neuron theory, theoretical calculation and analysis of the relationship between current stimulation and scalp voltage. The results showed that under different external electric stimulation, brain stimulation current and voltage change size is inversely proportional to the frequency, is proportional to the exciting current intensity. The results lay a theoretical foundation for the the necessary mechanism of light stimulation voltage change characteristics of brain at different frequency and intensity.
2. based on the EEG technology, study the different effects of light intensity on the scalp to stimulate the human eye brain voltage changes. The results show that with the same frequency but different brightness light irradiation time variation of scalp voltage of the brain is different: brightness is stronger, the scalp voltage is greater, whereas the smaller. On the basis of the experimental results for people to study brain voltage light stimulus magnitude effect provide meaningful.
3., based on EEG technology, we studied the effect of different frequency (color) light stimulation on human brain to the change of brain scalp voltage. The results showed that the smaller the external light frequency was, the bigger the brain scalp voltage was, and the smaller it was.
4. eye light is irradiated to the photoreceptor cells in the process of acceptance, hyperpolarization, light signals are converted to electrical signals. Based on the current results of brain stimulation voltage of the scalp voltage of light stimulation with different intensity variation characteristics were studied: the mechanism of light stimulation in patients with epilepsy eyes outside when the current amplitude caused by cerebral cortex nerve cell membrane by the greatly increased, making the scalp voltage change sharply. The stronger the light stimulation, cause cell membrane transmembrane current is stronger, the brain voltage change caused by the greater. When the light intensity caused by the transmembrane current exceeds a certain threshold, it will cause a a series of physiological or biochemical side effects induced by epilepsy. For further study of brain light stimulation effect, provide a meaningful theoretical basis for prevention and treatment of epilepsy and other brain diseases.
5. calculation models based on the derivation of the stimulation current scalp voltage changes, and changes in the relationship between the external light stimulation according to different frequency and voltage on the scalp, scalp voltage light stimulation with different frequency characteristics of mechanism: when the low frequency light to stimulate the eyes, the the cerebral cortex neurons in membrane current of low frequency, long cell discharge, and the number of neurons is more, so the voltage changes to test the scalp. Provide a meaningful theoretical basis for the study of neuronal optical frequency characteristics further.

【學(xué)位授予單位】：廣西大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2013
【分類號】：R741.044

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