發(fā)布時(shí)間：2018-04-04 16:20

  本文選題：無(wú)線(xiàn)能量傳輸　切入點(diǎn)：植入式　出處：《上海交通大學(xué)》2012年碩士論文

【摘要】：植入式遙測(cè)是生物醫(yī)學(xué)測(cè)量技術(shù)發(fā)展最快的分支之一,用來(lái)長(zhǎng)期實(shí)時(shí)跟蹤處于無(wú)拘束狀態(tài)下的生物體的生理或生化參數(shù)的變化,這對(duì)生物體本身的研究,對(duì)采用藥物和人工器官及輔助裝置的療效評(píng)估都有十分重要的意義。此外,由于測(cè)量裝置植入體內(nèi)后,可保證植入裝置處在接近恒溫和少干擾的良好環(huán)境中,使測(cè)量準(zhǔn)確性大幅度提高。 本論文依托上海市贊德醫(yī)療器械有限公司橫向課題項(xiàng)目“動(dòng)物生理參數(shù)檢測(cè)系統(tǒng)研究”在國(guó)家自然科學(xué)基金(NO.30800235)資助下,對(duì)植入式動(dòng)物生理參數(shù)監(jiān)測(cè)系統(tǒng)進(jìn)行了深入研究。 論文提出了基于無(wú)線(xiàn)能量傳輸技術(shù)的植入式動(dòng)物生理參數(shù)遙測(cè)系統(tǒng)的設(shè)計(jì)方案,系統(tǒng)由無(wú)線(xiàn)能量傳輸設(shè)備、植入式微型電子膠囊、體外數(shù)據(jù)記錄儀和數(shù)據(jù)處理軟件組成,無(wú)線(xiàn)能量傳輸設(shè)備能夠?yàn)橹踩胧轿⑿碗娮幽z囊供能,從而避免了頻繁更換電池給動(dòng)物帶來(lái)的痛苦;植入式微型電子膠囊能夠檢測(cè)到動(dòng)物的心電、血壓和體溫三項(xiàng)生理參數(shù)信號(hào),通過(guò)無(wú)線(xiàn)方式將測(cè)得的數(shù)據(jù)發(fā)射至體外;體外數(shù)據(jù)記錄儀無(wú)線(xiàn)接收、存儲(chǔ)和顯示數(shù)據(jù);上位機(jī)數(shù)據(jù)處理軟件讀取、處理記錄儀存儲(chǔ)的數(shù)據(jù),并繪制生理參數(shù)波形。 本文從總體上給出了體內(nèi)裝置和體外裝置的結(jié)構(gòu),著重介紹該系統(tǒng)設(shè)計(jì)的關(guān)鍵技術(shù)。無(wú)線(xiàn)能量傳輸技術(shù)體外裝置采用矩形螺線(xiàn)管發(fā)射線(xiàn)圈為電子膠囊進(jìn)行供能,電子膠囊內(nèi)部通過(guò)三維線(xiàn)圈接收能量,為電子膠囊正常工作提供能量;植入式微型電子膠囊集成了信號(hào)采集、濾波、放大、AD轉(zhuǎn)換功能,通過(guò)射頻芯片將數(shù)據(jù)無(wú)線(xiàn)發(fā)射至體外;體外數(shù)據(jù)記錄儀集成了無(wú)線(xiàn)數(shù)據(jù)接收、存儲(chǔ)和液晶顯示功能;數(shù)據(jù)處理軟件采用MATLAB進(jìn)行編寫(xiě),集成了數(shù)據(jù)讀取功能和繪圖功能,為用戶(hù)提供了圖形用戶(hù)界面。 論文通過(guò)模擬實(shí)驗(yàn)和動(dòng)物實(shí)驗(yàn)驗(yàn)證了系統(tǒng)的性能,模擬實(shí)驗(yàn)分別采用直流電壓和無(wú)線(xiàn)能量傳輸設(shè)備為膠囊供電,直流供電模擬實(shí)驗(yàn)表明膠囊能夠精確地檢測(cè)到動(dòng)物生理參數(shù),無(wú)線(xiàn)供能模擬實(shí)驗(yàn)表明無(wú)線(xiàn)傳輸?shù)哪芰磕軌驖M(mǎn)足膠囊的正常工作,體外數(shù)據(jù)記錄儀能接收到膠囊發(fā)射的數(shù)據(jù),但心電信號(hào)線(xiàn)必須經(jīng)過(guò)屏蔽才能測(cè)得模擬心電信號(hào);動(dòng)物實(shí)驗(yàn)中采用新西蘭兔作為實(shí)驗(yàn)動(dòng)物,測(cè)得了有效的血壓和體溫,而心電信號(hào)被電磁場(chǎng)淹沒(méi)。 為長(zhǎng)期連續(xù)監(jiān)測(cè)動(dòng)物生理參數(shù),本文設(shè)計(jì)并實(shí)現(xiàn)了一種基于無(wú)線(xiàn)能量傳輸技術(shù)的植入式遙測(cè)系統(tǒng),植入式微型電子膠囊尺寸僅為Φ13×30mm,重6.38g,功耗約150mW,選用新西蘭兔進(jìn)行活體實(shí)驗(yàn),測(cè)得體溫范圍為37.2-37.3°C,基線(xiàn)噪聲為0.1°C,血壓范圍為74-83mmHg,基線(xiàn)噪聲為3mmHg。最后,本文總結(jié)了該系統(tǒng)功能上的創(chuàng)新,并提出了系統(tǒng)今后的發(fā)展方向,供以后的科研工作參考。
[Abstract]:Implantable telemetry is one of the fastest-growing branches of biomedical measurement technology, which is used to track the changes of physiological or biochemical parameters of organisms in an unconstrained state for a long time in real time.It is of great significance to evaluate the efficacy of drugs, artificial organs and assistive devices.In addition, the accuracy of measurement can be greatly improved because the measuring device is in a good environment of close to constant temperature and less interference after it is implanted into the body.Based on the horizontal project of Shanghai Zander Medical device Co., Ltd., "Research on Animal physiological Parameter Detection system", the implanted animal physiological parameter monitoring system was deeply studied with the aid of National Natural Science Foundation of China (no. 30800235).This paper presents a design scheme of implantable animal physiological parameter telemetry system based on wireless energy transmission technology. The system consists of wireless energy transmission equipment, implanted microelectronic capsule, in vitro data recorder and data processing software.Wireless energy transmission devices can provide energy for implanted microelectronic capsules, thereby avoiding the pain caused by frequent battery changes. Implanted microelectronic capsules can detect three physiological parameters, including ECG, blood pressure and body temperature.The measured data is transmitted to the external body by wireless mode; the external data recorder receives, stores and displays data wirelessly; the upper computer data processing software reads, processes the data stored by the recorder, and draws the physiological parameter waveform.In this paper, the structure of the device in vivo and in vitro is given, and the key technology of the system design is emphatically introduced.In vitro, the rectangular solenoid transmitting coil is used to supply energy for the electronic capsule, which receives the energy through the three-dimensional coil in order to provide the energy for the normal operation of the electronic capsule.The implantable microelectronic capsule integrates the functions of signal acquisition, filtering, amplifying AD conversion, and radio-frequency chip to transmit the data wirelessly to the outside body, and the external data recorder integrates the functions of wireless data receiving, storage and LCD display.The data processing software is written by MATLAB, which integrates the function of data reading and drawing, and provides the user with graphical user interface.The performance of the system is verified by simulation experiments and animal experiments. DC voltage and wireless energy transmission equipment are used to power the capsules respectively. The DC power supply simulation experiments show that the capsules can accurately detect the physiological parameters of animals.The simulation experiment of wireless energy supply shows that the wireless transmission energy can meet the normal operation of the capsule, and the data from the capsule can be received by the in vitro data recorder, but the ECG signal line must be shielded in order to get the simulated ECG signal.In animal experiments, New Zealand rabbits were used as experimental animals to measure effective blood pressure and body temperature, and electrocardiogram (ECG) was submerged by electromagnetic field.In order to continuously monitor animal physiological parameters for a long time, an implantable telemetering system based on wireless energy transmission technology was designed and implemented. The size of implanted microelectronic capsule was only 桅 13 脳 30 mm, the weight was 6.38 g, and the power consumption was about 150 MW.The temperature range was 37.2-37.3 擄C, the baseline noise was 0.1 擄C, the blood pressure range was 74-83 mmHg, and the baseline noise was 3mmHg.Finally, this paper summarizes the innovation of the system function, and puts forward the future development direction of the system for future scientific research work.
【學(xué)位授予單位】：上海交通大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2012
【分類(lèi)號(hào)】：R197.39

【引證文獻(xiàn)】

相關(guān)期刊論文 前2條

1 劉大生;顏國(guó)正;;一種采用單電源的心電信號(hào)遙測(cè)系統(tǒng)的設(shè)計(jì)[J];電子測(cè)量技術(shù);2012年08期

2 吳艷茹;司偉;易小林;孟燕軍;范振中;;小動(dòng)物無(wú)創(chuàng)式心率監(jiān)測(cè)儀的研制及應(yīng)用[J];鄭州大學(xué)學(xué)報(bào)(醫(yī)學(xué)版);2012年06期

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本文編號(hào)：1710726