本文選題：可注射水凝膠　切入點：殼聚糖　出處：《化學(xué)工程》2017年08期

【摘要】：針對干眼癥臨床治療對淚點栓產(chǎn)品的研發(fā)需求,文中利用殼聚糖(CS)與β-甘油磷酸鈉(GP)可在37℃發(fā)生溫敏相變形成凝膠的特性,采用生物相容性優(yōu)良的海藻酸鈉(SA)為共混材料,改進CS-GP凝膠存在溫敏相變時間較長、機械強度差、易于溶脹和降解、熱穩(wěn)定性差等問題,并采用掃描電子顯微測試、紅外光譜分析、熱重分析、壓縮彈性模量和流變性能分析等方法對復(fù)合凝膠性能進行了表征。結(jié)果表明:制備的復(fù)合溶膠在37℃環(huán)境可快速相變形成具有多孔網(wǎng)絡(luò)結(jié)構(gòu)且強度適宜的凝膠,可注射性良好。當(dāng)CS質(zhì)量濃度為25 mg/mL,GP質(zhì)量濃度為600 mg/mL,V(CS)∶V(GP)=4.5∶1時,添加40 mg/mL SA可將CS-GP-SA復(fù)合凝膠的相變時間調(diào)控為10 s以內(nèi),壓縮彈性模量為67 k Pa,損耗模量G″和儲能模量G'值比為0.003 1,平衡溶脹率為5%,置于模擬淚液中48 d時的質(zhì)量殘留率為61%。凝膠性能可以滿足淚道栓塞的應(yīng)用需求。
[Abstract]:According to the research needs of clinical treatment of dry eye of punctal plug products, using the shell chitosan (CS) and sodium glycerophosphate (GP) can occur at 37 DEG C transition temperature sensitive gel forming properties, with excellent biocompatibility of alginate (SA) blend materials, improved CS-GP gel are temperature sensitive phase transition a long time, poor mechanical strength, easy to swelling and degradation problems, poor thermal stability, and using scanning electron microscopy, infrared spectroscopy, thermogravimetric analysis, compressive elastic modulus and rheological analysis were used to characterize the composite gel performance. The results showed that the preparation of the sol in 37 DEG C can be fast phase formation with porous network structure and the appropriate intensity of gel, injectable good. When CS concentration was 25 mg/mL, GP concentration was 600 mg/mL, V (CS): V (GP) =4.5: 1, add 40 mg/mL SA can be CS-GP-SA composite gel The phase transition time is controlled within 10 s, the compression modulus is 67 K Pa, the loss modulus G and storage modulus G'ratio is 0.0031, the equilibrium swelling rate is 5%, and the mass remaining rate in the simulated tear 48 D is 61%. gel, which can meet the application requirement of lacrimal duct embolization.

【作者單位】： 西北大學(xué)化工學(xué)院;陜西省眼科研究所;西安外事學(xué)院醫(yī)學(xué)院;商洛學(xué)院生物醫(yī)藥與食品工程學(xué)院;
【基金】：陜西省自然科學(xué)基金資助項目(2015JM2044;2014JQ2067) 國家自然科學(xué)基金資助項目(21306152) 陜西省教育廳專項科研計劃項目(16JK1770)
【分類號】：R318.08;TQ427.26
，

本文編號：1668971