本文選題：合成生物學(xué)　切入點(diǎn)：基因線路　出處：《生物工程學(xué)報(bào)》2017年03期

【摘要】：合成生物學(xué)旨在建立一套完整的工程理論和方法,通過設(shè)計(jì)和組裝基本生物學(xué)元件,更為有效地實(shí)現(xiàn)復(fù)雜生物系統(tǒng)的設(shè)計(jì),并使其完成可編程的生物學(xué)功能。近年來隨著可編程基因組元件的出現(xiàn),特別是CRISPR和CRISPRi技術(shù)平臺的建立和完善,使得合成生物學(xué)進(jìn)入了一個(gè)全新發(fā)展的時(shí)期。本文重點(diǎn)綜述CRISPR等基因組編輯和調(diào)控技術(shù),其在構(gòu)建可編程生物學(xué)元件和復(fù)雜基因線路的應(yīng)用以及合成生物學(xué)在醫(yī)學(xué)中(稱為醫(yī)學(xué)合成生物學(xué))的發(fā)展前景。
[Abstract]:Synthetic biology aims to establish a complete set of engineering theories and methods to achieve the design of complex biological systems more effectively by designing and assembling basic biological components. In recent years, with the emergence of programmable genome components, especially the establishment and improvement of CRISPR and CRISPRi technology platform, Synthetic biology has entered a new period of development. This paper focuses on CRISPR and other genome editing and regulation techniques, Its applications in the construction of programmable biological elements and complex gene circuits and the development prospects of synthetic biology in medicine (called medical synthetic biology).
【作者單位】： 上海交通大學(xué)醫(yī)學(xué)院附屬仁濟(jì)醫(yī)院風(fēng)濕科中美合成生物學(xué)中心;斯坦福大學(xué)生物工程系;
【基金】：美國國立衛(wèi)生研究院(No.DP5OD017887) 上海交通大學(xué)醫(yī)學(xué)院附屬仁濟(jì)醫(yī)院資助~~
【分類號】：Q789;R318
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本文編號：1664781