本文選題：骨缺損　切入點(diǎn)：骨填充材料　出處：《青島大學(xué)》2017年碩士論文

【摘要】：目的:富含β-磷酸三鈣(β-TCP)的骨填充材料與Bio-Oss骨填充材料做對比分析,評價(jià)富含β-磷酸三鈣的骨填充材料的臨床療效和安全。方法:本研究選取在青島大學(xué)附屬醫(yī)院就醫(yī)的拔牙患者40例,所選患者為18-70歲之間,有前牙或者前磨牙疾患需要拔除,口腔衛(wèi)生狀況良好,無全身系統(tǒng)性疾病。經(jīng)統(tǒng)一研究員對受試者對患者進(jìn)行口腔專科檢查和血液檢查,篩選入組患者。本實(shí)驗(yàn)采取雙盲實(shí)驗(yàn)方法。將患者隨機(jī)分為試驗(yàn)組和對照組,試驗(yàn)組采用富含β-磷酸三鈣的骨填充材料,對照組采用瑞士Geistlich公司的Bio-Oss骨填充材料。對經(jīng)過篩檢入組的患者進(jìn)行患牙拔除術(shù)并在拔牙窩植入對應(yīng)骨粉,拔牙窩雙層明膠海綿覆蓋,拉攏縫合牙齦,術(shù)后即刻拍CT記錄牙槽嵴的高度和寬度以及CT值,觀察兩組骨填充材料的安全性:1周復(fù)診拆線,觀察黏膜愈合狀況;拔牙創(chuàng)有無出現(xiàn)骨粉脫落,術(shù)后6個(gè)月復(fù)診拍CT測量牙槽嵴的高度和寬度以及CT值。將拔牙后即刻CT與拔牙后六個(gè)月之間的CT數(shù)據(jù)進(jìn)行比較,觀察其有效性。計(jì)算出牙槽嵴垂直向骨吸收量和頰舌向骨吸收量。進(jìn)一步分析試驗(yàn)組與對照組的統(tǒng)計(jì)學(xué)差異,觀察試驗(yàn)組骨填充材料與對照組骨填充材料的有效性和安全性的差異。結(jié)果:1.口腔內(nèi)臨床檢查40位受試者牙齦生長狀況良好,試驗(yàn)組與對照組術(shù)后24小時(shí)大部分患者疼痛為Ⅰ級(jí)疼痛,疼痛程度不明顯。試驗(yàn)組有2位患者出現(xiàn)II級(jí)疼痛,對照組患者有3位患者出現(xiàn)II級(jí)疼痛。試驗(yàn)組和對照組共40例患者拔牙創(chuàng)等級(jí)都為甲級(jí)愈合,未有乙級(jí)愈合或丙級(jí)愈合的患者。試驗(yàn)組和對照組患者拔牙創(chuàng)愈合時(shí)間大部分都在7天以內(nèi),大于7天的患者,實(shí)驗(yàn)組2人,對照組1人,受試者均未出現(xiàn)感染、過敏等嚴(yán)重不良反應(yīng),術(shù)后一周復(fù)診均未出現(xiàn)術(shù)區(qū)感染,骨粉脫落等情況。實(shí)驗(yàn)組和對照組均未發(fā)生不良事件。術(shù)后六個(gè)月拔牙窩處牙槽骨豐滿未有骨嵴骨棱出現(xiàn)。試驗(yàn)組與對照組安全性對比P0.052.CT觀察及CT測量值。CT可見實(shí)驗(yàn)組和對照組患者的成骨效果均很好。試驗(yàn)組與對照組骨吸收的平均距離在水平方向在1.9mm左右,垂直方向在1mm左右。CT值在900-1000左右。術(shù)前術(shù)后試驗(yàn)組與對照組骨吸收量無明顯差異P0.05,同一時(shí)間段試驗(yàn)組與對照組CT值均數(shù)相近,同一時(shí)間段兩組數(shù)據(jù)比較P值0.05,試驗(yàn)組與對照組數(shù)據(jù)無統(tǒng)計(jì)學(xué)差異,但同組患者的術(shù)后6個(gè)月CT值高于術(shù)后即刻CT值,P0.05。試驗(yàn)組與對照組無明顯差異。結(jié)論:在拔牙窩骨缺損中,將富含β-磷酸三鈣骨填充材料與瑞士Geistlich公司的Bio-Oss骨填充材料對比,骨缺損區(qū)軟硬組織生長狀況及兩者六個(gè)月的成骨效果和骨吸收量無明顯差異。其療效和安全性與瑞士Geistlich公司的Bio-Oss骨填充材料相當(dāng)。
[Abstract]:Objective: to compare the 尾 -TCP-rich bone filling material with Bio-Oss bone filling material. To evaluate the clinical efficacy and safety of bone filling materials rich in 尾 -tricalcium phosphate. Methods: forty patients with extraction of teeth were selected from Qingdao University affiliated Hospital. The selected patients were between 18 and 70 years of age. The patients with anterior teeth or premolar diseases needed to be removed. The oral hygiene condition is good, there is no systemic disease of the whole body. The patients were randomly divided into two groups: the experimental group and the control group. The patients in the experimental group were filled with bone filled with 尾 -tricalcium phosphate (尾 -tricalcium phosphate). The patients in the control group were treated with Bio-Oss bone filling material from Geistlich Company of Switzerland. The patients in the screening group were treated with extraction of the affected teeth and the corresponding bone powder was implanted in the extraction nest. The double layer gelatin sponge was used to cover the extraction nest and the gingiva was closed and sutured. The height, width and CT value of alveolar ridge were recorded by CT immediately after operation. The safety of bone filling materials in the two groups was observed. The height and width of alveolar ridge and CT value were measured 6 months after operation. Ct data were compared between immediately after extraction and 6 months after extraction. The vertical bone resorption and buccal bone resorption of alveolar ridge were calculated. The statistical difference between the experimental group and the control group was further analyzed. The efficacy and safety of bone filling materials in the experimental group and the control group were observed. Results the gingival growth status of 40 subjects with clinical examination in oral cavity was good. 24 hours after operation, most of the patients in the trial group and the control group had pain of grade 鈪，

本文編號(hào)：1656505