本文選題：骨缺損　切入點(diǎn)：基因工程　出處：《中國(guó)骨質(zhì)疏松雜志》2014年08期 　論文類型：期刊論文

【摘要】：臨床上對(duì)于骨缺損的治療從截肢,自體骨、異體骨移植,到目前的生物活性材料、骨組織工程、基因工程治療,依然沒(méi)有能夠徹底進(jìn)行骨缺損修復(fù)的方法,這也一直是醫(yī)學(xué)界關(guān)注和研究的熱點(diǎn)。究其原因一方面是因?yàn)楦鞣N方法的技術(shù)水平還不完善如手術(shù)時(shí)間和方法掌握,生物活性材料的制作等,另一方面是因?yàn)楣侨睋p的局部反應(yīng)較復(fù)雜如骨髓損傷較重,血運(yùn)較差,斷端存在的硬化反應(yīng)等以及傳統(tǒng)治療后的并發(fā)癥較多如免疫排斥較重,成骨作用不良,骨折不愈合,神經(jīng)損傷長(zhǎng)期引發(fā)的疼痛等,這些原因都在不同程度的制約骨缺損研究的前進(jìn)。只有從骨的修復(fù)與生長(zhǎng)機(jī)制出發(fā),聯(lián)合應(yīng)用多種方法,相互補(bǔ)其不足,從中找到突破點(diǎn),才能完善骨缺損修復(fù),縮短治療時(shí)間,提高病人的生活質(zhì)量。本文簡(jiǎn)要描述自體和異體骨移植在治療骨缺損時(shí)的優(yōu)缺點(diǎn),著重?cái)⑹龉墙M織工程與基因工程近年來(lái)的研究熱點(diǎn),包括生物材料的更新?lián)Q代、目的細(xì)胞的種類增加、生長(zhǎng)因子與基因載體的研究進(jìn)展等,這其中探討了生物修復(fù)骨缺損工程中兩種方法各自的利弊,闡述兩種工程聯(lián)合應(yīng)用的優(yōu)缺互補(bǔ),最后提出骨缺損治療研究方向上的新思路與新問(wèn)題。
[Abstract]:Clinical treatment for bone defects ranging from amputation, autogenous bone, allogeneic bone transplantation, to current bioactive materials, bone tissue engineering, gene engineering, still has not been able to complete the bone defect repair method. This has always been the focus of attention and research in the medical field. On the one hand, the reason is that the technical level of various methods is still not perfect, such as the operation time and method mastery, the production of bioactive materials, etc. On the other hand, the local reaction of bone defect is more complex, such as serious bone marrow injury, poor blood circulation, sclerosing reaction at the broken end, and complications after traditional treatment, such as serious immune rejection, poor osteogenesis, nonunion of fracture, etc. The pain caused by nerve injury for a long time, these reasons are restricting the progress of bone defect research in varying degrees. Only from the mechanism of bone repair and growth, combined use of a variety of methods, complement each other's shortcomings, and find a breakthrough point. This article briefly describes the advantages and disadvantages of autogenous and allogeneic bone grafts in the treatment of bone defects, and focuses on the recent research hotspots in bone tissue engineering and genetic engineering, in order to improve the repair of bone defects, shorten the treatment time and improve the quality of life of the patients. Including the replacement of biomaterials, the increase in the number of target cells, the progress of research on growth factors and gene vectors, etc., among which the advantages and disadvantages of the two methods in the bioremediation of bone defects are discussed. The advantages and disadvantages of the two kinds of combined applications are described. Finally, new ideas and problems in the research direction of bone defect treatment are put forward.
【作者單位】： 西藏民族學(xué)院醫(yī)學(xué)院高原環(huán)境與疾病相關(guān)基因研究實(shí)驗(yàn)室 生命科學(xué)基礎(chǔ)實(shí)驗(yàn)室;
【分類號(hào)】：R318.0

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本文編號(hào)：1631968