本文選題：生物力學(xué)　切入點(diǎn)：松質(zhì)骨　出處：《醫(yī)用生物力學(xué)》2014年05期 　論文類型：期刊論文

【摘要】：目的測(cè)量人體多部位松質(zhì)骨礦質(zhì)密度、軸向彈性模量,建立礦質(zhì)密度與軸向彈性模量相關(guān)關(guān)系的本構(gòu)方程,為國人有限元材料屬性賦值提供依據(jù)。方法采取10例成人新鮮尸體作為樣本源,選取脛骨近端、大轉(zhuǎn)子、股骨頸、肱骨頭和椎體5個(gè)部位的松質(zhì)骨,加工成直徑約6 mm、長約30或40 mm的準(zhǔn)試樣。測(cè)量尺寸并計(jì)算體積,CT掃描試樣骨礦質(zhì)密度。對(duì)松質(zhì)骨試樣進(jìn)行力學(xué)性能測(cè)試,分析不同部位松質(zhì)骨彈性模量。對(duì)礦質(zhì)密度與軸向彈性模量關(guān)系進(jìn)行線性與冪次回歸分析。結(jié)果測(cè)試成功的試樣來自5個(gè)部位,共169枚,其中脛骨近端52枚,大轉(zhuǎn)子31枚,股骨頸15枚,肱骨頭17枚,椎體54枚;5個(gè)部位松質(zhì)骨礦質(zhì)密度、軸向彈性模量均有所差異,線性相關(guān)性均較好(0.850r20.785),3個(gè)部位(脛骨近端、大轉(zhuǎn)子、椎體)的冪次相關(guān)性較好(0.871r20.825),2個(gè)部位(肱骨頭、股骨頸)的冪次相關(guān)性較弱(0.671r20.643)。結(jié)論各個(gè)部位骨礦質(zhì)密度與軸向彈性模量的線性和冪次回歸的相關(guān)性均較高,且同部位兩種回歸的r2值之間無明顯差異;可應(yīng)用于體外檢測(cè)患者的骨骼質(zhì)量,準(zhǔn)確分辨骨質(zhì)變化的部位,配合有限元建模能夠預(yù)測(cè)骨折的風(fēng)險(xiǎn)。
[Abstract]:Objective to measure the mineral density and axial elastic modulus of cancellous bone in human body, and to establish the constitutive equation of the relationship between mineral density and axial modulus of elasticity. Methods Ten fresh adult cadavers were used as samples to select cancellous bone in proximal tibia, trochanter, neck of femur, head of humerus and vertebral body. Processed into quasi-specimens of about 6 mm in diameter and about 30 or 40 mm in length. Measurements of dimensions and calculation of bone mineral density of CT scanning specimens. Mechanical properties of cancellous bone specimens, The relationship between mineral density and axial elastic modulus was analyzed by linear and power regression analysis. Results 169 specimens were obtained from 5 parts, including 52 proximal tibia and 31 large trochanter. There were 15 neck of femur, 17 heads of humerus, 54 vertebrae, 5 parts of cancellous bone mineral density and axial modulus of elasticity, the linear correlation was better than 0.850r20.785, 3 parts (proximal tibia, great trochanter), The power correlation of vertebral body is better than that of the other two parts (head of humerus and neck of femur). Conclusion the correlation between bone mineral density and axial modulus of elasticity is higher than that in other two parts (head of humerus, neck of femur), conclusion the correlation between the density of bone mineral and the regression of axial modulus of elasticity is higher in two parts (head of humerus and neck of femur). There is no significant difference between the two regression values of R2 in the same site, which can be used to detect the bone mass of patients in vitro, to distinguish the site of bone change accurately, and to predict the risk of fracture in combination with finite element modeling.
【作者單位】： 上海交通大學(xué)附屬第一人民醫(yī)院骨科;上海交通大學(xué)機(jī)械與動(dòng)力工程學(xué)院;
【基金】：國家重點(diǎn)基礎(chǔ)研究發(fā)展計(jì)劃(973)子課題(2011CB711005) 國家自然科學(xué)基金資助項(xiàng)目(81071234,81272002)
【分類號(hào)】：R318

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本文編號(hào)：1569823