發(fā)布時(shí)間：2018-02-26 04:16

  本文關(guān)鍵詞： 紅霉素衍生物L(fēng)Y267108 骨水泥 體外釋放　出處：《南京大學(xué)》2012年碩士論文　論文類型：學(xué)位論文

【摘要】：目的：探討紅霉素衍生物L(fēng)Y267108加入骨水泥后,其體外的釋放規(guī)律。方法：實(shí)驗(yàn)共分為5組,A1-A5為在40克骨水泥中分別加入0.5g、1g、1.5g、2g、2.5gLY267108制成模型,放入模擬人工體液進(jìn)行浸提,并于設(shè)定的時(shí)間點(diǎn),從每個(gè)樣本浸提液中,提取1m1浸提液,儲(chǔ)存于-20℃的冰箱中,實(shí)驗(yàn)完成后用高效液相色譜法測(cè)定不同時(shí)間點(diǎn)藥物的釋放量。結(jié)果：在第1周內(nèi)(1d-7d),5組藥物均呈爆發(fā)性釋放,各組間相同時(shí)段釋放比率差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05),第7天,各組釋放比率約為11%左右；自第2周至第8周間(8d-56d)藥物的釋放速度明顯減慢,緩慢釋放期內(nèi)在各組LY267108累計(jì)釋放速度差異有統(tǒng)計(jì)學(xué)意義(P0.05),且比較各組累計(jì)釋放速率A1組A2組A5組A3組A4組。結(jié)論：在第1周(1d-7d),LY267108呈爆發(fā)性釋放,且各組相同時(shí)段的釋放百分率相似,自第2周至第8周(8d-56d)LY267108的釋放速度明顯減慢；在40g骨水泥中加入2.0g LY267108,LY267108更趨于穩(wěn)定、持久的從骨水泥中釋放。
[Abstract]:Objective: To investigate the effect of erythromycin derivatives LY267108 into bone cement after release in vitro. Methods: mice were divided into 5 groups, A1-A5 0.5g, were added in 40 grams of bone cement in 1g, 1.5g, 2G, 2.5gLY267108 made into model, extracting the simulated body fluid, and to set time points, from each sample extract, extract 1m1 extract, refrigerator stored in -20 DEG C, after completion of the experiment was determined by HPLC at different time point of drug release. Results: in first weeks (1d-7d), the 5 groups showed the same time the explosive release, release ratio between groups there was no statistically significant difference (P0.05), seventh days, each release ratio is about 11%; from second to eighth weeks (8d-56d) between the drug release rate slowed down, slow release period of each LY267108 cumulative release rate was statistically significant difference (P0.05), and compared the The cumulative release rate of A1 group A2 group A5 group A3 group A4 group. Conclusion: at first weeks (1d-7d), LY267108 explosive release, the release percentage and similar groups of the same period, from second to eighth weeks (8d-56d) LY267108 release rate slowed down; adding 2.0g LY267108 in 40g bone cement, LY267108 more stable, sustained release from bone cement.

【學(xué)位授予單位】：南京大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2012
【分類號(hào)】：R318.1

【參考文獻(xiàn)】

相關(guān)期刊論文 前2條

1 呂厚山,馬迪,丁海明;三種抗生素骨水泥抗菌作用和機(jī)械強(qiáng)度的研究[J];中華外科雜志;1998年S1期

2 黃粵,劉昌勝,邵慧芳,劉壯峻;妥布霉素對(duì)磷酸鈣骨水泥性能的影響[J];中國(guó)生物醫(yī)學(xué)工程學(xué)報(bào);2002年05期

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本文編號(hào)：1536473