本文關(guān)鍵詞： 粉針劑 螺桿計量 連續(xù)充填 壓電振動 協(xié)同設計 仿真分析　出處：《哈爾濱商業(yè)大學》2012年碩士論文　論文類型：學位論文

【摘要】：粉針劑分裝機是制藥行業(yè)的重要設備。由于分裝速度、精度與劑量變化適應性等技術(shù)指標均達不到國際領先水平,而且新產(chǎn)品開發(fā)周期長、設計手段落后,使得國產(chǎn)分裝機缺乏市場競爭力。因此,利用現(xiàn)代設計方法,對粉針劑分裝機的關(guān)鍵部件—計量與充填裝置進行結(jié)構(gòu)與工作參數(shù)的協(xié)同設計,顯得尤為關(guān)鍵,具有非�，F(xiàn)實的意義。 論文分析了粉針劑的物性,深入研究了粉針劑的流動性、松裝密度等特性與分裝速度、分裝精度的關(guān)系,分析了粉狀物料的計量與充填方式,確定了基于間歇式螺桿計量、連續(xù)式壓電振動充填的粉針劑計量充填研究方案,以克服粉針劑物性對分裝速度和精度的影響。 建立精密計量螺桿的數(shù)學模型,結(jié)合SolidWorks二次開發(fā)模塊和VB,建立了計量螺桿的參數(shù)化快速設計功能模塊。詳細設計計量螺桿、攪拌葉片與粉杯的結(jié)構(gòu)參數(shù),以改善傳統(tǒng)容積計量調(diào)節(jié)困難的缺陷。采用伺服電機直連計量螺桿的方式,精確控制螺桿的轉(zhuǎn)動,保證計量精度。 選用壓電雙晶片作為振動驅(qū)動源,合理設計了溜槽與板彈簧的結(jié)構(gòu)參數(shù),提出了此種振型固有頻率的計算方法,并擬定了粉針劑在輸送料盤上的理想運動過程,確定跳躍邊界條件。 采用壓電雙晶片驅(qū)動的方式,設計了新型的粉料壓電振動充填裝置；分析了粉針劑的振動輸送與充填的機理,確定粉針劑振動輸送邊界條件。提出機構(gòu)固有頻率的計算方法,優(yōu)化設計了溜槽與板彈簧的結(jié)構(gòu)參數(shù),以提高壓電振動充填裝置性能。 深入分析了裝置計量與充填協(xié)同工作的工作原理,確定兩裝置在容積量與時間兩個方面的協(xié)同工作參數(shù),并以工作循環(huán)圖的方式表示整個計量充填周期的工作過程。利用SolidWorks軟件構(gòu)造計量與充填裝置的三維模型,結(jié)合COSMOS Motion模塊進行運動學仿真,確定了裝置的最佳工作參數(shù),并輸出相應的曲線,得出了系統(tǒng)達到最大充填速度的振動頻率為10Hz,振動送料器的最大旋轉(zhuǎn)速度為7.95rad/s。此外,還對板彈簧做了力學分析,驗證模型的合理性和可行性。
[Abstract]:Powder dispensing machine is an important equipment in the pharmaceutical industry. Due to the technical indexes such as speed, accuracy and adaptability of dosage change, it can not reach the international leading level, and the new product development cycle is long, and the design means lag behind. Therefore, it is very important to use modern design method to design the structure and working parameters of the key parts of powder dispenser, metering and filling device. Has very realistic significance. In this paper, the physical properties of the powder injection are analyzed, and the relationship between the fluidity and the loose density of the powder injection and the speed and precision of the powder injection is studied. The metering and filling method of the powder material is analyzed, and the metering method based on the intermittent screw is determined. In order to overcome the influence of the physical properties of powder injection on the speed and accuracy of split filling, the research scheme of continuous piezoelectric vibration filling is presented in this paper. The mathematical model of precision measuring screw was established. The parameterized and rapid design function module of metering screw was established with the combination of SolidWorks secondary development module and VB. The structural parameters of metering screw, agitating blade and powder cup were designed in detail. In order to improve the defects of the traditional volume measurement adjustment, the servo motor is directly connected with the measuring screw to accurately control the screw rotation and ensure the measurement accuracy. The piezoelectric bimorph is chosen as the vibration driving source, the structural parameters of the chute and plate spring are reasonably designed, the calculation method of the natural frequency of the vibration mode is put forward, and the ideal movement process of the powder injection on the conveying plate is worked out. Determine the jump boundary conditions. A new type of piezoelectric vibration filling device is designed by using piezoelectric bimorph drive, the mechanism of vibrating conveying and filling of powder injection is analyzed, the boundary condition of vibrating conveying of powder injection is determined, and the method of calculating the natural frequency of mechanism is put forward. The structural parameters of chute and plate spring are optimized to improve the performance of piezoelectric vibration filling device. The working principle of cooperative work between metering and filling is deeply analyzed, and the cooperative working parameters of the two devices in volume and time are determined. The working process of the whole metering and filling cycle is represented by the working cycle diagram. The 3D model of the metering and filling device is constructed by using SolidWorks software, and the kinematics simulation is carried out with the COSMOS Motion module, and the optimum working parameters of the device are determined. The corresponding curves are outputted, the vibration frequency of the system reaching the maximum filling speed is 10 Hz and the maximum rotating velocity of the vibrating feeder is 7.95 radr / s. In addition, the mechanical analysis of the plate spring is done to verify the rationality and feasibility of the model.
【學位授予單位】：哈爾濱商業(yè)大學
【學位級別】：碩士
【學位授予年份】：2012
【分類號】：TH788;TP391.72

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