發(fā)布時間：2018-02-22 23:48

  本文關(guān)鍵詞： 組織工程 生物相容性材料 血液透析液 生物材料 材料相容性 血液透析 一縮二乙二醇 聚乙烯吡咯烷酮 N N-二甲基乙酰胺 非溶劑致相分離法 中空纖維透析膜 Ⅱ型醫(yī)用聚氨酯材料 血液相容性　出處：《中國組織工程研究》2017年02期 　論文類型：期刊論文

【摘要】：背景:聚砜膜具備良好的抗生物抗降解性能,但臨床上對于以聚砜作為材料制備中空纖維透析膜的制備方法及血液相容性缺乏統(tǒng)一的標(biāo)準(zhǔn)。目的:觀察中空纖維透析膜的制備方法、傳遞特性及材料生物相容性。方法:以聚砜作為膜材料,將一縮二乙二醇作為致孔劑,聚乙烯吡咯烷酮作為改性劑,N,N-二甲基乙酰胺作為溶劑,利用非溶劑致相分離法制備中空纖維透析膜。采用掃描電鏡、超景深三維顯微鏡成像及孔隙率測試等測定透析膜的性能;利用超濾裝置完成傳遞參數(shù)截留率和水通量參數(shù)測定;通過溶血實驗、動態(tài)凝血時間實驗及血小板黏附實驗測定中空纖維透析膜的血液相容性,以Ⅱ型醫(yī)用聚氨酯材料作為陰性對照。結(jié)果和結(jié)論:1中空纖維透析膜形態(tài):制備的中空纖維透析膜斷面不對稱,質(zhì)量分?jǐn)?shù)17%透析膜中間層呈大孔狀結(jié)構(gòu),而質(zhì)量分?jǐn)?shù)19%,21%及23%的透析膜制備的中空纖維透析膜呈海綿狀結(jié)構(gòu);2中空纖維透析膜孔隙率:中空纖維透析膜和Ⅱ型醫(yī)用聚氨酯材料在膜面積相同的情況下,中空纖維透析膜密度顯著低于,孔隙率顯著大于陰性對照材料(P0.05);3中空纖維透析膜傳遞性能:中空纖維透析膜水體積及水通量,顯著高于陰性對照材料(P0.05);4中空纖維透析膜血液相容性:兩種材料共進行3次溶血實驗結(jié)果顯示:中空纖維透析膜平均吸光度值和溶血率顯著高于陰性對照材料(P0.05);動態(tài)凝血時間實驗及血小板黏附實驗結(jié)果顯示,中空纖維透析膜20,40,70 min動態(tài)凝血時間顯著短于陰性對照材料(P0.05)。結(jié)果提示:將聚砜作為膜材料,利用非溶劑致相分離法能程控制備生物相容性較好的中空纖維透析膜,材料具有良好的血液相容性及傳遞效率。
[Abstract]:Background: polysulfone membrane has good anti-biodegradability. But there is no uniform standard for the preparation and blood compatibility of hollow fiber dialysate membrane using polysulfone as the material in clinic. Objective: to observe the preparation method of hollow fiber dialysis membrane. Methods: Poly (sulfone) was used as membrane material, diethylene glycol was used as pore-forming agent, polyvinylpyrrolidone as modifier, N-dimethyl acetamide as solvent, polysulfone as membrane material, and polyvinylpyrrolidone as modifier. Hollow fiber dialysis membrane was prepared by non-solvent phase separation method. The properties of dialysis membrane were measured by scanning electron microscope (SEM), 3D imaging of depth of field and porosity test, and the parameters of transfer parameter rejection and water flux were measured by ultrafiltration device. The blood compatibility of hollow fiber dialysis membrane was determined by hemolysis test, dynamic coagulation time test and platelet adhesion test. Results and conclusion: the morphology of the hollow fiber dialysis membrane: the section of the hollow fiber dialysis membrane prepared was asymmetric, and the intermediate layer of 17% mass fraction dialysis membrane was macroporous. However, the hollow fiber dialysate membrane prepared with 21% and 23% mass fraction of hemodialysis membrane showed spongy structure and hollow fiber dialysate membrane porosity: under the same membrane area, the hollow fiber dialysis membrane and the type 鈪，

本文編號：1525614