本文關(guān)鍵詞： 組織工程支架 流場(chǎng) 微流動(dòng) 流-固耦合 流體剪應(yīng)力　出處：《機(jī)床與液壓》2017年15期 　論文類型：期刊論文

【摘要】：組織工程支架的結(jié)構(gòu)、空間走向、孔隙率是制約組織工程學(xué)發(fā)展的重要因素,支架內(nèi)微流體流場(chǎng)直接影響著細(xì)胞的吸附、增殖、分化和流-固耦合引起的支架應(yīng)力應(yīng)變,且支架內(nèi)微流體流場(chǎng)各種因素交互作用復(fù)雜,作用機(jī)制尚未明確,對(duì)其內(nèi)部微管孔中的微流體流動(dòng)特性的研究尚處于起步階段。通過(guò)對(duì)組織工程支架內(nèi)部流場(chǎng)及流體剪應(yīng)力和新組織相互影響的研究情況進(jìn)行闡述,發(fā)現(xiàn)在使用數(shù)值方法進(jìn)行模擬仿真的同時(shí),還缺少相應(yīng)的物理實(shí)驗(yàn)驗(yàn)證,而快速成型技術(shù)和新材料的發(fā)展,對(duì)搭建微流體實(shí)驗(yàn)平臺(tái),探索骨支架及內(nèi)部微流體流場(chǎng)的優(yōu)化具有一定的工程意義。
[Abstract]:The structure, spatial direction and porosity of tissue engineering scaffolds are important factors restricting the development of tissue engineering. The microfluid flow field in scaffolds directly affects the adsorption, proliferation, differentiation and stress-strain of scaffolds caused by fluid-solid coupling. The interaction of various factors in the microfluid flow field in the scaffold is complex, and the mechanism of the interaction is not clear. The study on the flow characteristics of microfluid in the inner microtubules is still in its infancy. Through the study of the flow field in the scaffold and the interaction between the fluid shear stress and the new structure, the paper describes the flow field of the scaffold and the interaction between the flow field and the new structure. It is found that the numerical method is used to simulate and simulate, and the corresponding physical experiment verification is lacking. However, with the development of rapid prototyping technology and new materials, the micro-fluid experimental platform is built. It is of engineering significance to explore the optimization of bone scaffold and internal microfluid flow field.
【作者單位】： 燕山大學(xué)河北省重型機(jī)械流體動(dòng)力傳輸與控制重點(diǎn)實(shí)驗(yàn)室;唐山工業(yè)職業(yè)技術(shù)學(xué)院機(jī)械工程系;燕山大學(xué)醫(yī)院;
【基金】：國(guó)家自然基金資助項(xiàng)目(51175448;51405424)
【分類號(hào)】：R318.08
，

本文編號(hào)：1514601