發(fā)布時間：2018-02-11 00:40

  本文關(guān)鍵詞： 骨缺損自修復(fù) 骨質(zhì)層 兔子 仿生拓撲優(yōu)化　出處：《新疆大學(xué)》2012年碩士論文　論文類型：學(xué)位論文

【摘要】：骨作為整個肉體的支承部件，在生命周期內(nèi)起重要的傳遞力臂使身體運動或搬運作用。骨是通過原有的基因關(guān)系而成形，在內(nèi)外生物力學(xué)環(huán)境下通過骨重建即造骨、吸骨、再成形的方式來優(yōu)化自身的拓撲結(jié)構(gòu)，從而創(chuàng)造出各種骨骼體系動態(tài)穩(wěn)定的結(jié)構(gòu)和拓撲形狀。因此，對骨生成、成長和成形過程中的骨質(zhì)、骨形變化規(guī)律及機理研究，不僅對現(xiàn)代生物力學(xué)、醫(yī)學(xué)臨床研究提供必要的科學(xué)依據(jù)，而在仿生拓撲優(yōu)化方法的研發(fā)及在實際工程應(yīng)用方面提供可靠的支撐參數(shù)。 本文主要從實驗研究出發(fā)，詳細介紹了骨重建機理的骨缺損自修復(fù)實驗過程、實驗觀測結(jié)果、并相關(guān)分析結(jié)果。實驗研究結(jié)果表明： 1).青年兔骨缺損自修復(fù)比成年兔的快得多，并且骨缺損自修復(fù)過程中孔內(nèi)填充的骨質(zhì)層出現(xiàn)強烈的不穩(wěn)定性。這種不穩(wěn)定性來自破骨細胞和造骨細胞的不平衡和強烈變化，造成骨形成和再吸收行為。 2).無論是成年兔還是青年兔在骨缺損自修復(fù)過程中軟質(zhì)骨和硬質(zhì)骨之間都存在著體積交叉變化的現(xiàn)象。這種交叉變化特性提示如下兩點：一是骨細胞之間的某種反應(yīng)擴散現(xiàn)象，即在骨缺損自修復(fù)過程中的骨形成與骨吸收之間的動態(tài)平衡現(xiàn)象；二是骨硬化現(xiàn)象，即軟質(zhì)骨被硬化導(dǎo)致體積降低，從而硬質(zhì)骨體積增加。 本文還對骨重建反映擴散數(shù)學(xué)模型進行了研究，，建立了用反映擴散方程的骨重建模型與有限元法耦合的仿生拓撲優(yōu)化分析方法，實現(xiàn)了考慮造骨和破骨機理的長方口骨缺損模型的數(shù)值模擬及拓撲優(yōu)化過程，驗證了iBone3D方法的有效性。
[Abstract]:Bone, as the supporting part of the whole body, plays an important role in the life cycle to transfer the force arm to make the body move or carry. The bone is formed through the original genetic relationship, and the bone is created and sucked through the bone reconstruction in the internal and external biomechanical environment. In order to create dynamic and stable structures and topological shapes of various bone systems, we study the regularity and mechanism of bone formation, bone shape change and bone formation in the process of bone formation, growth and formation. It not only provides the necessary scientific basis for modern biomechanics and medical clinical research, but also provides reliable supporting parameters in the research and development of bionic topology optimization methods and in practical engineering applications. Starting from the experimental research, this paper introduces in detail the self-repair process of bone defect, the experimental results, and the correlation analysis results. The experimental results show that:. 1. Bone defect self-repair in young rabbits is much faster than that in adult rabbits, and there is a strong instability in the bone layer filled in the hole during the self-repair of the bone defect. This instability arises from the imbalance and intense changes in the osteoclasts and osteoblasts. Causes bone formation and reabsorption. (2) there is a phenomenon of volume crossing between soft bone and hard bone in both adult and young rabbits during the process of self-repair of bone defect. The characteristics of this cross change indicate the following two points: one is a reaction and diffusion phenomenon between bone cells. That is, the dynamic balance between bone formation and bone resorption in the process of self-repair of bone defect, and the phenomenon of bone sclerosis, that is, the soft bone sclerosis leads to the reduction of volume, which increases the volume of hard bone. In this paper, the mathematical model of reflection diffusion of bone reconstruction is also studied, and a bionic topology optimization method is established by coupling the bone reconstruction model with finite element method, which reflects the diffusion equation. The numerical simulation and topology optimization process of the long square bone defect model considering the mechanism of osteogenesis and osteoclast are realized, and the validity of iBone3D method is verified.
【學(xué)位授予單位】：新疆大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2012
【分類號】：TB17;R318.01

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本文編號：1501828