本文關(guān)鍵詞： 骨折固定術(shù) 羥基磷灰石類(lèi) 組織工程 生物材料 材料相容性 復(fù)合生物可吸收材料 關(guān)節(jié)骨折 內(nèi)固定 生物相容性 生物可吸收性 替代材料　出處：《中國(guó)組織工程研究》2016年34期 　論文類(lèi)型：期刊論文

【摘要】：背景:近年來(lái),聚L-乳酸/聚乳酸乙醇酸共聚物/羥基磷灰石復(fù)合生物可吸收材料在關(guān)節(jié)骨折中得到應(yīng)用,效果理想。目的:分析聚L-乳酸/聚乳酸乙醇酸共聚物/羥基磷灰石復(fù)合生物可吸收材料在關(guān)節(jié)骨折內(nèi)固定中的生物相容性。方法:(1)體內(nèi)實(shí)驗(yàn):取22只新西蘭大兔,制備踝關(guān)節(jié)骨折模型,隨機(jī)分2組,復(fù)合材料組采用聚L-乳酸復(fù)合生物可吸收材料固定,金屬材料組采用金屬支架固定。術(shù)后/聚乳酸乙醇酸共聚物/羥基磷灰石7 d,觀察兩組治療效果及并發(fā)癥情況;(2)體外實(shí)驗(yàn):將聚L-乳酸/聚乳酸乙醇酸共聚物/羥基磷灰石復(fù)合生物可吸收材料與MG-63細(xì)胞共培養(yǎng),觀察細(xì)胞增殖、黏附。結(jié)果與結(jié)論:(1)體內(nèi)實(shí)驗(yàn)結(jié)果:金屬材料組術(shù)后9只兔骨折部位愈合良好,2只出現(xiàn)并發(fā)癥;復(fù)合材料組骨折愈合良好,未出現(xiàn)并發(fā)癥;(2)體外實(shí)驗(yàn)結(jié)果:接種于復(fù)合支架1 d后,細(xì)胞全部貼壁生長(zhǎng),多為梭形;培養(yǎng)3 d后細(xì)胞數(shù)量開(kāi)始增加,排列緊密且相對(duì)規(guī)則,顯示出旺盛的生長(zhǎng)能力,培養(yǎng)1-7 d的細(xì)胞毒性為0或1級(jí)。共培養(yǎng)3 d時(shí),復(fù)合材料表面細(xì)胞為梭形或多邊形,細(xì)胞伸展良好,細(xì)胞之間存在明顯的連接,并且細(xì)胞表面的毛躁部分深入材料表面進(jìn)行生長(zhǎng),表現(xiàn)出良好的黏附性;(3)結(jié)果表明:聚L-乳酸/聚乳酸乙醇酸共聚物/羥基磷灰石復(fù)合生物可吸收材料具有良好的生物相容性。
[Abstract]:Background: in recent years, poly (L-lactic acid) / poly (lactic acid glycolate) / hydroxyapatite composite bioabsorbable materials have been applied in joint fractures. Objective: to analyze the biocompatibility of poly (L-lactic acid) / poly (lactic acid glycolate) / hydroxyapatite composite bioabsorbable material in the internal fixation of joint fracture. The ankle fracture model was established and randomly divided into two groups. The composite group was fixed with Poly (L-lactic acid) composite bioabsorbable material. The metal material group was fixed with metal scaffold. After operation / poly (lactic acid glycolate copolymer / hydroxyapatite) for 7 days, the therapeutic effect and complications of the two groups were observed in vitro: Poly (lactic acid / polylactic acid glycolate copolymer / poly (lactic acid) / poly (lactic acid glycolate) /. Hydroxyapatite composite bioabsorbable materials co-cultured with MG-63 cells. Observation of cell proliferation and adhesion. Results and conclusions in vivo experiment results: 9 rabbits in the metal material group had good fracture healing and 2 had complications, while the composite group had good fracture healing. Results of in vitro experiment: after inoculation with the composite scaffold for 1 day, all the cells adhered to the wall, most of them were fusiform, and after 3 days of culture, the number of cells began to increase, and the arrangement was tight and regular, showing strong growth ability. When cultured for 3 days, the cells on the composite surface were fusiform or polygonal, the cells extended well, and there were obvious connections between the cells. The results showed that poly (lactic acid) / poly (lactic acid glycolate copolymer / hydroxyapatite) composite bioabsorbable materials had good biocompatibility.
【作者單位】： 貴州省六盤(pán)水市水礦控股集團(tuán)總醫(yī)院骨一科;遵義醫(yī)學(xué)院附屬醫(yī)院骨科;
【分類(lèi)號(hào)】：R318.08;R683

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