本文關(guān)鍵詞：聚乳酸復(fù)合材料預(yù)成乳牙根管樁的基礎(chǔ)研究　出處：《吉林大學(xué)》2014年碩士論文　論文類型：學(xué)位論文

  更多相關(guān)文章： 左旋聚乳酸 羥基磷灰石微球 乳牙根管樁 生物相容性

【摘要】：在過(guò)去半個(gè)世紀(jì)中，乳牙齲病的治療重心逐漸由拔除性治療向修復(fù)性治療轉(zhuǎn)移。修復(fù)性治療主要包括充填治療、嵌體修復(fù)及金屬預(yù)成冠修復(fù)。然而，在牙體組織嚴(yán)重缺損的病例中，牙冠修復(fù)之前，牙髓治療和根管內(nèi)固定技術(shù)是十分必要的。應(yīng)用于乳牙根管內(nèi)固定技術(shù)材料主要包括：金屬樁核、樹(shù)脂樁核、纖維樁及脫落乳牙制備的生物樁。金屬、樹(shù)脂和纖維樁無(wú)法被人體組織吸收，為不影響乳恒牙的正常替換，用于乳牙時(shí)多位于牙頸部1/3，這易導(dǎo)致材料脫落或牙根的折斷等；脫落乳牙制備的生物樁雖能克服植入長(zhǎng)度不足和牙根吸收的問(wèn)題，但存在感染和排斥等潛在風(fēng)險(xiǎn)。因此，制備具有一定生物力學(xué)性能、良好的生物相容性及與乳牙根生理性吸收同步降解性能的乳牙根管樁，具有重要臨床意義。 本研究以NH4H2PO4、Ca（CH3COO）2H2O及CH3COONH4作為原料制備羥基磷灰石微球。按羥基磷灰石質(zhì)量分?jǐn)?shù)為0%、3%、5%、7%和9%，采用溶液共混法和熱壓成型法制備聚乳酸/羥基磷灰石復(fù)合材料。通過(guò)掃描電子顯微鏡(SEM)、X射線晶體衍射（XRD）及傅立葉變換紅外光譜（FT-IR）檢測(cè)羥基磷灰石物理化學(xué)性能；萬(wàn)能材料試驗(yàn)機(jī)測(cè)試復(fù)合材料的彎曲強(qiáng)度和彈性模量；MTT法檢測(cè)羥基磷灰石復(fù)合材料對(duì)L929細(xì)胞相對(duì)增殖率（RGR）的影響，旨在探討復(fù)合材料作為乳牙根管樁的可行性，為乳牙殘根、殘冠的臨床治療提供新的思路。結(jié)果顯示：所制備的羥基磷灰石為片層狀晶體所構(gòu)成的微球形，直徑約1μｍ，，大小均勻，形態(tài)一致，結(jié)晶度及純度高。與單純聚乳酸組比較，含有羥基磷灰石各復(fù)合材料組的彎曲強(qiáng)度和彈性模量明顯增高（P0.01），羥基磷灰石質(zhì)量分?jǐn)?shù)為5%復(fù)合材料的彎曲強(qiáng)度和彈性模量達(dá)最優(yōu)值（138MPa、4600MPa）。MTT法檢測(cè)羥基磷灰石質(zhì)量分?jǐn)?shù)為0%、3%、5%、7%和9%各組復(fù)合材料RGR均在93%以上，細(xì)胞毒性級(jí)別均為0~1級(jí)。結(jié)論可知：聚乳酸/羥基磷灰石復(fù)合材料具有一定的力學(xué)性能,無(wú)細(xì)胞毒性，有望成為理想的乳牙根管樁材料。
[Abstract]:Over the past half century, the focus of the treatment of deciduous caries has gradually shifted from extubation to restorative treatment, which mainly includes filling, inlay and metal precrown repair. Pulp treatment and root canal internal fixation are very necessary in the patients with severe defect of tooth tissue before crown repair. The main materials used in primary teeth root canal internal fixation include: metal post core and resin post core. Fiber post and biological post made of deciduous teeth. Metal, resin and fiber post can not be absorbed by human tissue. In order not to affect the normal replacement of deciduous permanent teeth, most of them are located at the neck of 1/3 when used in deciduous teeth. This will easily lead to material falling off or the root of the broken, and so on; Although the biological post prepared by deciduous teeth can overcome the problems of insufficient implant length and root resorption, there are potential risks such as infection and rejection. Therefore, the preparation has certain biomechanical properties. It is of great clinical significance to have good biocompatibility and simultaneous degradation with physiologic absorption of deciduous teeth. In this study, hydroxyapatite microspheres were prepared by using NH _ 4H _ 2PO _ 4O _ 3COO _ 2H _ 2O and CH3COONH4 as raw materials. The content of hydroxyapatite was 0% or 3%. Polylactic acid / hydroxyapatite composites were prepared by solution blending and hot pressing. X-ray crystal diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR) were used to detect the physical and chemical properties of hydroxyapatite. The bending strength and elastic modulus of the composite were measured by universal material testing machine. The effect of hydroxyapatite composite on the relative proliferation rate of L929 cells was detected by MTT method. The aim of this study was to explore the feasibility of using the composite material as root canal post of deciduous teeth as the residual root of deciduous teeth. The results showed that the prepared hydroxyapatite was a microsphere composed of lamellar crystals with a diameter of about 1 渭 m, uniform size and uniform morphology. Compared with the pure PLA group, the flexural strength and elastic modulus of the composites containing hydroxyapatite increased significantly (P0.01). The flexural strength and elastic modulus of the composite material with hydroxyapatite content of 5% reached the optimum value: 138MPA, 4600MPA, MTT, the mass fraction of hydroxyapatite was 0%. The RGR of 7% and 9% groups of composites were above 93%, and the cytotoxic grade was 0 ~ 1. Conclusion: Polylactic acid / hydroxyapatite composite has certain mechanical properties. It has no cytotoxicity and is expected to be an ideal material for primary root canal post.
【學(xué)位授予單位】：吉林大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2014
【分類號(hào)】：R783.1

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本文編號(hào)：1395186