慢性特發(fā)性蕁麻疹患者血清IL-6、IL-12P70、β-內(nèi)啡肽及組胺測定及意義
發(fā)布時間：2019-04-19 04:49
【摘要】： 目的通過測定慢性特發(fā)性蕁麻疹(CIU)患者血清中IL-6、IL-12P70、β-內(nèi)啡肽及組胺的水平,初步探討神經(jīng)精神因素在CIU發(fā)病機制中的作用。 方法選擇門診確診的CIU患者共62例(其中在取血時處于發(fā)作狀態(tài)者35例,非發(fā)作狀態(tài)者27例),選擇健康志愿者34例作為對照組。應(yīng)用ELISA法檢測發(fā)作狀態(tài)、非發(fā)作狀態(tài)CIU患者及健康對照組血清IL-6、IL-12P70、β-內(nèi)啡肽及組胺的含量。應(yīng)用SPSS17.0統(tǒng)計軟件包進(jìn)行統(tǒng)計學(xué)處理。 結(jié)果①IL-6水平：CIU發(fā)作狀態(tài)組、非發(fā)作狀態(tài)組、健康對照組血清水平分別為458.19±72.79pg/ml,408.19±68.79pg/ml,432.32±92.38pg/ml,差異無統(tǒng)計學(xué)意義(p＞0.05)。②IL-12P70水平：CIU發(fā)作狀態(tài)組、非發(fā)作狀態(tài)組、健康對照組血清IL-12P70水平分別為286.39±138.06pg/ml,328.39±112.96pg/ml,366.76±115.82pg/ml,差異有統(tǒng)計學(xué)意義(p0.05),其中發(fā)作狀態(tài)組血清IL-12P70水平低于健康對照組,差異有統(tǒng)計學(xué)意義(p0.05)。非發(fā)作狀態(tài)組與健康對照組血清IL-12P70水平差異無統(tǒng)計學(xué)意義(p0.05)。非發(fā)作狀態(tài)組與發(fā)作狀態(tài)組血清IL-12P70水平差異無統(tǒng)計學(xué)意義(p0.05)。③β-內(nèi)啡肽水平：CIU發(fā)作狀態(tài)組、非發(fā)作狀態(tài)組、健康對照組血清β-內(nèi)啡肽水平分別19.42±5.93ng/ml,18.70±6.12ng/ml,15.70±4.92ng/ml,差異有統(tǒng)計學(xué)意義(p0.05),其中發(fā)作狀態(tài)組及非發(fā)作狀態(tài)組血清β-內(nèi)啡肽水平均高于健康對照組,差異有統(tǒng)計學(xué)意義(p0.05)。發(fā)作狀態(tài)組與非發(fā)作狀態(tài)組血清β-內(nèi)啡肽水平差異無統(tǒng)計學(xué)意義(p0.05)。④組胺水平：CIU發(fā)作狀態(tài)組、非發(fā)作狀態(tài)組、健康對照組血清組胺水平分別為34.03±14.32ng/ml,27.70±9.32ng/ml,20.61±10.71ng/ml,差異有統(tǒng)計學(xué)意義(p0.05),其中發(fā)作狀態(tài)組血清組胺水平高于健康對照組,差異有統(tǒng)計學(xué)意義(p0.01)。非發(fā)作狀態(tài)組血清組胺水平高于健康對照組,差異有統(tǒng)計學(xué)意義(p0.05)。發(fā)作狀態(tài)組血清組胺水平高于非發(fā)作狀態(tài)組,差異有統(tǒng)計學(xué)意義(p＜0.05)。⑤相關(guān)性分析：發(fā)作狀態(tài)組血清β-內(nèi)啡肽與組胺水平成正相關(guān)(r=0.712,p0.01),組胺與IL-12P70水平成負(fù)相關(guān)(r=-0.357,p0.05),β-內(nèi)啡肽與IL-12P70水平無相關(guān)性(r=0.167,p0.05)。非發(fā)作狀態(tài)組血清β-內(nèi)啡肽與組胺水平成正相關(guān)(r=0.615,p＜0.05)。非發(fā)作狀態(tài)組血清組胺與IL-12P70無明顯相關(guān)性(r=0.128,p0.05)。非發(fā)作狀態(tài)組血清β-內(nèi)啡肽與IL-12P70水平無相關(guān)性(r=0.147,p＞0.05)。 結(jié)論①血清IL-12P70水平降低,提示Th1/Th2免疫失衡可能在CIU的發(fā)病機制中起重要作用。②組胺在CIU的發(fā)病中起重要作用。③組胺可能通過抑制細(xì)胞免疫,造成機體T1/T2免疫失衡,從而誘發(fā)和(或)加重CIU的發(fā)生。④血清β-內(nèi)啡肽水平升高初步提示神經(jīng)精神因素在CIU的發(fā)病中的作用。⑤神經(jīng)精神因素可能通過引起機體Th1/Th2免疫失衡和(或)直接刺激肥大細(xì)胞脫顆粒釋放組胺來誘發(fā)和(或)加重CIU患者的病情。
[Abstract]:Aim to investigate the role of neuropsychological factors in the pathogenesis of chronic idiopathic urticaria (CIU) by measuring the serum levels of IL-6,IL-12P70, 尾-endorphin and histamine in patients with chronic idiopathic urticaria. Methods A total of 62 CIU patients (35 in seizure state and 27 in non-seizure state) were enrolled in this study. 34 healthy volunteers were selected as control group. The levels of serum IL-6,IL-12P70, 尾-endorphin and histamine in patients with and without CIU and healthy controls were detected by ELISA method. SPSS17.0 statistical software package was used for statistical processing. Results the serum levels of 1IL-6 were 458.19 鹵72.79 PG / ml, 408.19 鹵68.79 PG / ml, 432.32 鹵92.38 PG / ml in CIU attack group, non-attack state group and healthy control group, respectively. The levels of serum 2IL-12P70 were 286.39 鹵138.06 PG / ml, 328.39 鹵112.96 PG / ml, 366.76 鹵115.82 PG / ml in CIU attack group, non-attack state group and healthy control group, respectively (p > 0.05). The difference was statistically significant (p0.05), in which the level of serum IL-12P70 in the attack state group was lower than that in the healthy control group, the difference was statistically significant (p0.05). There was no significant difference in serum IL-12P70 level between non-seizure group and healthy control group (p0.05). There was no significant difference in serum IL-12P70 level between the non-seizure group and the attack state group (p0.05). 3 尾-endorphin levels: CIU attack state group, non-seizure state group, 3 尾-endorphin level. The serum 尾-endorphin levels in healthy control group were 19.42 鹵5.93 ng / ml, 18.70 鹵6.12 ng / ml, 15.70 鹵4.92 ng / ml, respectively (p0.05). The serum 尾-endorphin levels in the seizure group and the non-seizure group were significantly higher than those in the healthy control group (p0.05). There was no significant difference in serum 尾-endorphin levels between seizure group and non-seizure group (p0.05). 4 histamine levels were 34.03 鹵14.32 ng / ml in CIU attack group, 34.03 鹵14.32 ng / ml in non-seizure state group, and 34.03 鹵14.32 ng / ml in healthy control group. 27.70 鹵9.32ng / ml and 20.61 鹵10.71ng / ml, the difference was statistically significant (p0.05), in which the serum histamine level in the attack group was higher than that in the healthy control group (p0.01). The serum histamine level in non-seizure group was significantly higher than that in healthy control group (p0.05). The serum histamine level in the seizure group was significantly higher than that in the non-seizure group (p < 0.05). 5. There was a positive correlation between the serum 尾-endorphin level and histamine level in the seizure group (r = 0.712, p0.01), and there was a positive correlation between 尾-endorphin and histamine level in the seizure group (p < 0.05). Histamine was negatively correlated with the level of IL-12P70 (r = 0.357, p0.05), but 尾-endorphin was not correlated with the level of IL-12P70 (r = 0.167, p0.05). There was a positive correlation between serum 尾-endorphin and histamine level in non-seizure group (r = 0.615, p < 0.05). There was no significant correlation between serum histamine and IL-12P70 in non-seizure group (r = 0.128, p 0.05). There was no correlation between serum 尾-endorphin and IL-12P70 (r = 0.147, p > 0.05). Conclusion 1 the decrease of serum IL-12P70 level suggests that Th1/Th2 immune imbalance may play an important role in the pathogenesis of CIU. 2 histamine may play an important role in the pathogenesis of CIU. 3 histamine may inhibit cellular immunity. Causing immune imbalance in the body's T1/T2, 4 the increase of serum 尾-endorphin level suggests the role of neuropsychological factors in the pathogenesis of CIU. 5 the neuropsychological factors may be related to the immune imbalance of Th1/Th2 and the pathogenesis of CIU. 5. The increase of serum 尾-endorphin levels suggests that neuropsychological factors may play an important role in the pathogenesis of CIU. 5. (or) stimulating mast cells to degranulate and release histamine directly to induce and / or aggravate the condition of patients with CIU.
【學(xué)位授予單位】：青島大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2010
【分類號】：R758.24
本文編號：2460616
[Abstract]:Aim to investigate the role of neuropsychological factors in the pathogenesis of chronic idiopathic urticaria (CIU) by measuring the serum levels of IL-6,IL-12P70, 尾-endorphin and histamine in patients with chronic idiopathic urticaria. Methods A total of 62 CIU patients (35 in seizure state and 27 in non-seizure state) were enrolled in this study. 34 healthy volunteers were selected as control group. The levels of serum IL-6,IL-12P70, 尾-endorphin and histamine in patients with and without CIU and healthy controls were detected by ELISA method. SPSS17.0 statistical software package was used for statistical processing. Results the serum levels of 1IL-6 were 458.19 鹵72.79 PG / ml, 408.19 鹵68.79 PG / ml, 432.32 鹵92.38 PG / ml in CIU attack group, non-attack state group and healthy control group, respectively. The levels of serum 2IL-12P70 were 286.39 鹵138.06 PG / ml, 328.39 鹵112.96 PG / ml, 366.76 鹵115.82 PG / ml in CIU attack group, non-attack state group and healthy control group, respectively (p > 0.05). The difference was statistically significant (p0.05), in which the level of serum IL-12P70 in the attack state group was lower than that in the healthy control group, the difference was statistically significant (p0.05). There was no significant difference in serum IL-12P70 level between non-seizure group and healthy control group (p0.05). There was no significant difference in serum IL-12P70 level between the non-seizure group and the attack state group (p0.05). 3 尾-endorphin levels: CIU attack state group, non-seizure state group, 3 尾-endorphin level. The serum 尾-endorphin levels in healthy control group were 19.42 鹵5.93 ng / ml, 18.70 鹵6.12 ng / ml, 15.70 鹵4.92 ng / ml, respectively (p0.05). The serum 尾-endorphin levels in the seizure group and the non-seizure group were significantly higher than those in the healthy control group (p0.05). There was no significant difference in serum 尾-endorphin levels between seizure group and non-seizure group (p0.05). 4 histamine levels were 34.03 鹵14.32 ng / ml in CIU attack group, 34.03 鹵14.32 ng / ml in non-seizure state group, and 34.03 鹵14.32 ng / ml in healthy control group. 27.70 鹵9.32ng / ml and 20.61 鹵10.71ng / ml, the difference was statistically significant (p0.05), in which the serum histamine level in the attack group was higher than that in the healthy control group (p0.01). The serum histamine level in non-seizure group was significantly higher than that in healthy control group (p0.05). The serum histamine level in the seizure group was significantly higher than that in the non-seizure group (p < 0.05). 5. There was a positive correlation between the serum 尾-endorphin level and histamine level in the seizure group (r = 0.712, p0.01), and there was a positive correlation between 尾-endorphin and histamine level in the seizure group (p < 0.05). Histamine was negatively correlated with the level of IL-12P70 (r = 0.357, p0.05), but 尾-endorphin was not correlated with the level of IL-12P70 (r = 0.167, p0.05). There was a positive correlation between serum 尾-endorphin and histamine level in non-seizure group (r = 0.615, p < 0.05). There was no significant correlation between serum histamine and IL-12P70 in non-seizure group (r = 0.128, p 0.05). There was no correlation between serum 尾-endorphin and IL-12P70 (r = 0.147, p > 0.05). Conclusion 1 the decrease of serum IL-12P70 level suggests that Th1/Th2 immune imbalance may play an important role in the pathogenesis of CIU. 2 histamine may play an important role in the pathogenesis of CIU. 3 histamine may inhibit cellular immunity. Causing immune imbalance in the body's T1/T2, 4 the increase of serum 尾-endorphin level suggests the role of neuropsychological factors in the pathogenesis of CIU. 5 the neuropsychological factors may be related to the immune imbalance of Th1/Th2 and the pathogenesis of CIU. 5. The increase of serum 尾-endorphin levels suggests that neuropsychological factors may play an important role in the pathogenesis of CIU. 5. (or) stimulating mast cells to degranulate and release histamine directly to induce and / or aggravate the condition of patients with CIU.
【學(xué)位授予單位】：青島大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2010
【分類號】：R758.24
【參考文獻(xiàn)】
相關(guān)期刊論文 前10條
1 孫仁山,劉榮卿,葉慶佾,刁慶春,向明明,張黎,黃秀英;慢性特發(fā)性蕁麻疹患者血清組胺釋放活性的檢測[J];第三軍醫(yī)大學(xué)學(xué)報;2000年04期
2 楊嫻,李其林;女性慢性蕁麻疹患者血清性激素水平的研究[J];廣東藥學(xué)院學(xué)報;2004年02期
3 周武慶;神經(jīng)肽與皮膚免疫和炎癥[J];國外醫(yī)學(xué).皮膚性病學(xué)分冊;1997年06期
4 馬楨林;慢性特發(fā)性蕁麻疹的發(fā)病機理[J];國外醫(yī)學(xué)(皮膚性病學(xué)分冊);1998年04期
5 孫良丹,張學(xué)軍,楊森;自身免疫性蕁麻疹的研究進(jìn)展[J];國外醫(yī)學(xué)(皮膚性病學(xué)分冊);2003年05期
6 呂靜;李惠;;幽門螺桿菌致慢性蕁麻疹的發(fā)病機制[J];國際皮膚性病學(xué)雜志;2007年05期
7 鄭文軍,潘尚領(lǐng),林有坤,施煥中,梁伶;慢性蕁麻疹患者血清細(xì)胞因子的臨床研究[J];臨床檢驗雜志;2004年04期
8 顧富祥,孫火寶,水從龍;慢性蕁麻疹患者血清抗幽門螺桿菌抗體的檢測及意義[J];臨床皮膚科雜志;1998年01期
9 虞海燕,岑建萍,高錦程;慢性蕁麻疹患者IL-4、IL-6及IFN-γ的檢測[J];臨床皮膚科雜志;1998年06期
10 黨倩麗,陸學(xué)東,張小艷;慢性蕁麻疹患者血清IL-4、IFN-γ及IgE水平觀察[J];臨床皮膚科雜志;2000年04期
，本文編號：2460616
本文鏈接：http://sikaile.net/yixuelunwen/pifb/2460616.html
最近更新
教材專著
