復方白芨膏聯(lián)合派瑞松治療手部角化性濕疹的臨床研究
發(fā)布時間：2019-03-13 16:45
【摘要】： 手部濕疹(HE)作為一種常見的局限性濕疹類疾病,發(fā)病率越來越高。其發(fā)病人群、病因和臨床表現(xiàn)的特殊性,皮損反復發(fā)作,纏綿難愈,使其治療相當困難。目前,正在被作為一種相對獨立的疾病受到越來越多學者的關(guān)注。外用皮質(zhì)類固醇是最常用的治療方法,并且需要長期的良好的皮膚護理措施。然而,類固醇長期應用可能會引起皮膚萎縮、毛細血管擴張、色素沉著等副作用并可能導致激素依賴,停藥后易復發(fā),因此無論病人和醫(yī)生都非常期待新的治療手部濕疹的措施。近年來中醫(yī)治療手部濕疹的研究取得了一些進展,更是出現(xiàn)了很多劑型,為該病的治療提供了更多的方法。 目的 本研究擬通過觀察復方白芨膏聯(lián)合派瑞松治療前后手部角化性濕疹患者的臨床癥狀變化,評價外用派瑞松聯(lián)合復方白芨膏對手部角化性濕疹的臨床療效和安全性,為進一步改進中藥配方提供依據(jù),為減輕手部濕疹的癥狀,提高患者的生活質(zhì)量,探索更好的預防措施和治療方法。 方法 這是一個前瞻性隨機對照單盲試驗,收集2009年6月~2010年2月在廣東省第二中醫(yī)院皮膚科就診的輕、中度手部角化性濕疹患者。根據(jù)納入標準和排除標準,將符合入組標準的80例患者隨機分為兩組,其中治療組40人和對照組40人,治療組每日清潔手部后,皮損處先后外搽派瑞松軟膏、復方白芨膏,之后揉按1分鐘,2次/天。對照組每日清潔手部后,皮損處外搽派瑞松軟膏后揉按1分鐘,2次/天。兩組均囑咐患者注意手部皮膚護理,避免接觸堿性洗滌劑及化工產(chǎn)品等其他易致敏物品,并且每周復診一次。于初診及四周后分別對兩組病人評定其手部濕疹嚴重性指數(shù)及瘙癢程度評分,并以此對療效及安全性進行評價,所有數(shù)據(jù)應用SPSS17.0統(tǒng)計軟件進行分析。 結(jié)果 治療組38例完成臨床試驗,對照組39例完成臨床試驗。綜合療效方面,治療組與對照組比較,治療組治愈率為44.7%,總有效率為92.1%；對照組治愈率為17.9%,總有效率為79.5%。統(tǒng)計學分析,兩組綜合療效比較,有顯著性差異(p0.05)。皮損面積比較,治療組與對照組比較,治療組治愈率為21.1%,總有效率為78.9%；對照組治愈率為7.7%,總有效率為46.2%。統(tǒng)計學分析,兩組面積療效比較,有顯著性差異(p=0.012,p0.05)。瘙癢程度方面,治療組和對照組治療前后,瘙癢程度均有明顯下降,經(jīng)統(tǒng)計學分析,具有非常顯著性差異(P0.01)；兩組療效比較,經(jīng)統(tǒng)計學分析,差異有顯著性(p=0.007,p0.01)。治療組和對照組在治療前后比較,臨床癥狀,皮損面積,HESCI評分均有不同程度下降,經(jīng)統(tǒng)計學檢驗,認為具有顯著性差異(P0.01)；兩組臨床癥狀、皮損面積、HESCI評分評分下降程度比較,治療組均明顯優(yōu)于對照組,經(jīng)統(tǒng)計學檢驗,認為差異具有顯著性(P0.05)。不良反應：對照組2例患者局部出現(xiàn)輕度灼熱感,繼續(xù)用藥后,灼熱感消失,治療組未見不良反應。兩組患者均未見全身不良反應。 結(jié)論 復方白芨膏聯(lián)合派瑞松治療組明顯降低了手部角化性濕疹患者的HESCI評分,并且明顯緩解瘙癢程度、減少皮損面積,復方白芨膏聯(lián)合派瑞松治療組的臨床綜合療效和各項臨床指標均優(yōu)于單用派瑞松對照組,且未見明顯不良反應,耐受性好,值得臨床推廣。
[Abstract]:Hand eczema (HE), as a common type of localized eczema, has a higher incidence. The particularity of the disease, the cause and the clinical manifestation, the repeated attack of the skin lesion, the difficulty of winding the skin, and the treatment of the skin lesion are quite difficult. At present, as a relatively independent disease, more and more scholars are concerned. External corticosteroids are the most commonly used methods of treatment and require long-term good skin care. However, long-term use of steroids may cause side effects such as skin atrophy, telangiectasia, pigmentation, and the like, and may lead to hormone-dependent, easy-to-relapse after drug withdrawal, and therefore, no matter the patient and the doctor are looking forward to new measures to treat hand eczema. In recent years, some progress has been made in the study of the treatment of hand eczema by traditional Chinese medicine, and a lot of dosage forms have been made, and more methods are provided for the treatment of the disease. Objective The purpose of this study is to evaluate the clinical efficacy and safety of the combination of the compound white paste and the combination of the combination of the compound white paste and the combination of the compound white paste for the treatment of the keratosis eczema of the hand keratosis. In order to further improve the clinical symptoms, the clinical effect and the safety of the compound white-cream combined with the compound white-cream for the treatment of the keratosis eczema of the hand-keratosis were evaluated. The formulation provides the basis for relieving the symptoms of hand eczema, improving the quality of life of patients, and exploring better prevention Measures And a treatment method. The method is a prospective, randomized controlled, single-blind trial, which collects the dermatology of the second middle hospital in Guangdong Province from June 2009 to February 2010. The patients with mild and moderate hand keratosis were randomly divided into two groups according to the criteria for inclusion and exclusion criteria,40 in the treatment group and 40 in the control group, and after the treatment group was cleaned the hand once a day, the skin lesions were once cleaned with a soft extract, and the compound white Paste, and then knead for 1 minute,2 times/ day. After the control group was cleaned daily, the outside of the skin lesion The two groups instructed the patient to pay attention to the hand skin care, to avoid contact with alkaline detergent and chemical products, etc. He was easily sensitized and revisited once a week. The severity index and the degree of itching of the hand eczema of the two groups were assessed after the first visit and four weeks, and the efficacy and safety were evaluated as a result, and all the data were applied to the S PS S17.0 Statistical software analysis. Results treatment In the treatment group, the cure rate of the treatment group was 44.7% and the total effective rate was 92.1%. The cure rate of the control group was 17.9% and the total effective rate was 79.5%. Compared with the control group, the cure rate of the treatment group was 21.1% and the total effective rate was 78.9%. The cure rate of the control group was 7.7% and the total effective rate was 46.2%. There was a significant difference (p = 0.012, p0.05). The level of itching in the treatment group and the control group was significantly reduced before and after the treatment group and the control group (P <0.01). The difference was significant (p = 0.007, p0.01). The treatment group and the control group were compared with the control group before and after the treatment, and the clinical symptoms, the area of the skin lesions and the HESCI scores were decreased to a different extent, and the difference between the two groups was considered to have a significant difference (P0.01). Compared with the control group, the symptom, the area of the skin lesion and the score of the HESCI score were lower, and the treatment group was better than the control group. The results showed that there was a significant difference between the two groups (P0.05). feeling, after continuing to use the medicine, the burning sensation disappears, treatment No adverse reaction was found in the group. No adverse reaction of the whole body was found in the two groups. The HESCI scores of the patients with eczema and the degree of itching, the area of the skin lesions, the combination of the compound white-cream and the combination of the pratia were excellent.
【學位授予單位】：廣州中醫(yī)藥大學
【學位級別】：碩士
【學位授予年份】：2010
【分類號】：R758.23
本文編號：2439577
[Abstract]:Hand eczema (HE), as a common type of localized eczema, has a higher incidence. The particularity of the disease, the cause and the clinical manifestation, the repeated attack of the skin lesion, the difficulty of winding the skin, and the treatment of the skin lesion are quite difficult. At present, as a relatively independent disease, more and more scholars are concerned. External corticosteroids are the most commonly used methods of treatment and require long-term good skin care. However, long-term use of steroids may cause side effects such as skin atrophy, telangiectasia, pigmentation, and the like, and may lead to hormone-dependent, easy-to-relapse after drug withdrawal, and therefore, no matter the patient and the doctor are looking forward to new measures to treat hand eczema. In recent years, some progress has been made in the study of the treatment of hand eczema by traditional Chinese medicine, and a lot of dosage forms have been made, and more methods are provided for the treatment of the disease. Objective The purpose of this study is to evaluate the clinical efficacy and safety of the combination of the compound white paste and the combination of the combination of the compound white paste and the combination of the compound white paste for the treatment of the keratosis eczema of the hand keratosis. In order to further improve the clinical symptoms, the clinical effect and the safety of the compound white-cream combined with the compound white-cream for the treatment of the keratosis eczema of the hand-keratosis were evaluated. The formulation provides the basis for relieving the symptoms of hand eczema, improving the quality of life of patients, and exploring better prevention Measures And a treatment method. The method is a prospective, randomized controlled, single-blind trial, which collects the dermatology of the second middle hospital in Guangdong Province from June 2009 to February 2010. The patients with mild and moderate hand keratosis were randomly divided into two groups according to the criteria for inclusion and exclusion criteria,40 in the treatment group and 40 in the control group, and after the treatment group was cleaned the hand once a day, the skin lesions were once cleaned with a soft extract, and the compound white Paste, and then knead for 1 minute,2 times/ day. After the control group was cleaned daily, the outside of the skin lesion The two groups instructed the patient to pay attention to the hand skin care, to avoid contact with alkaline detergent and chemical products, etc. He was easily sensitized and revisited once a week. The severity index and the degree of itching of the hand eczema of the two groups were assessed after the first visit and four weeks, and the efficacy and safety were evaluated as a result, and all the data were applied to the S PS S17.0 Statistical software analysis. Results treatment In the treatment group, the cure rate of the treatment group was 44.7% and the total effective rate was 92.1%. The cure rate of the control group was 17.9% and the total effective rate was 79.5%. Compared with the control group, the cure rate of the treatment group was 21.1% and the total effective rate was 78.9%. The cure rate of the control group was 7.7% and the total effective rate was 46.2%. There was a significant difference (p = 0.012, p0.05). The level of itching in the treatment group and the control group was significantly reduced before and after the treatment group and the control group (P <0.01). The difference was significant (p = 0.007, p0.01). The treatment group and the control group were compared with the control group before and after the treatment, and the clinical symptoms, the area of the skin lesions and the HESCI scores were decreased to a different extent, and the difference between the two groups was considered to have a significant difference (P0.01). Compared with the control group, the symptom, the area of the skin lesion and the score of the HESCI score were lower, and the treatment group was better than the control group. The results showed that there was a significant difference between the two groups (P0.05). feeling, after continuing to use the medicine, the burning sensation disappears, treatment No adverse reaction was found in the group. No adverse reaction of the whole body was found in the two groups. The HESCI scores of the patients with eczema and the degree of itching, the area of the skin lesions, the combination of the compound white-cream and the combination of the pratia were excellent.
【學位授予單位】：廣州中醫(yī)藥大學
【學位級別】：碩士
【學位授予年份】：2010
【分類號】：R758.23
【引證文獻】
相關(guān)碩士學位論文 前1條
1 郭宇;自擬脾腎雙補方治療更年期手足部慢性濕疹的臨床療效觀察[D];北京中醫(yī)藥大學;2013年
，本文編號：2439577
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