【摘要】：目的探討血清瘦素及生長(zhǎng)激素促泌素受體的內(nèi)源性配體Ghrelin水平與不同類型銀屑病的發(fā)生及其病情的相關(guān)性。方法 50例銀屑病患者及年齡、性別、體質(zhì)指數(shù)(BMI)與之均衡的正常人對(duì)照30例,采用ELISA檢測(cè)其血清瘦素及Ghrelin水平。結(jié)果銀屑病患者血清瘦素水平(3.11±1.16)ng/mL較正常人對(duì)照組(2.33±0.82)ng/mL顯著增高(P0.05):且與PASI評(píng)分呈正相關(guān)(r=0.915,P0.01),血清瘦素水平可見顯著的性別差異(P0.01);銀屑病患者血清Ghrelin水平(172.14±23.54)pg/mL較正常人對(duì)照組(143.67±15.76)pg/mL顯著增高(P0.01),且與PASI評(píng)分呈負(fù)相關(guān)(r=-0.309,P0.05)。結(jié)論銀屑病患者血清瘦素及Ghrelin水平升高,且與疾病嚴(yán)重程度有關(guān)聯(lián),提示瘦素和Ghrelin可能參與銀屑病的發(fā)病機(jī)制。
[Abstract]:Objective to investigate the relationship between the levels of serum leptin and growth hormone receptor endogenous ligand Ghrelin and the occurrence of different types of psoriasis. Methods Serum leptin and Ghrelin levels were measured by ELISA in 50 psoriatic patients and 30 healthy controls with age, sex, body mass index (BMI). Results the serum leptin level in psoriatic patients (3.11 鹵1.16) was significantly higher than that in normal controls (2.33 鹵0.82) ng/mL (P0.05). There was a positive correlation between leptin and PASI score (r = 0.915, P 0.01). The serum leptin level showed significant gender difference (P0.01). The level of serum Ghrelin in psoriatic patients (172.14 鹵23.54) pg/mL was significantly higher than that in the control group (143.67 鹵15.76) pg/mL (P0.01), and was negatively correlated with PASI score (r-0.309) (P0.05). Conclusion Serum leptin and Ghrelin levels in patients with psoriasis were elevated and correlated with the severity of psoriasis, suggesting that leptin and Ghrelin might be involved in the pathogenesis of psoriasis.
【作者單位】： 濱州醫(yī)學(xué)院附屬醫(yī)院皮膚科;淄博市第三醫(yī)院;濱州醫(yī)學(xué)院附屬醫(yī)院輸血科;
【分類號(hào)】：R758.63

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