【摘要】：目的探討潤(rùn)燥止癢膠囊口服聯(lián)合鹵米松軟膏局部外用治療原發(fā)性皮膚淀粉樣變病的臨床療效及安全性。方法將就診于門(mén)診的129例原發(fā)性皮膚淀粉樣變病患者隨機(jī)分為治療組及對(duì)照組,其中治療組68例給予潤(rùn)燥止癢膠囊口服及鹵米松軟膏局部外用;對(duì)照組61例,僅給予鹵米松外用治療。分別在治療第2,4和8周末時(shí)進(jìn)行癥狀評(píng)分、療效判定和安全性評(píng)價(jià)。結(jié)果在治療的第2周末時(shí),治療組和對(duì)照組有效率分別為47.06%和45.90%,兩組差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05);在治療的第4和第8周末時(shí),治療組有效率為69.12%和83.82%,對(duì)照組為55.74%和62.30%,兩組差異均有統(tǒng)計(jì)學(xué)意義(P0.05)。兩組患者僅有輕微不良反應(yīng)。結(jié)論潤(rùn)燥止癢膠囊口服聯(lián)合鹵米松軟膏局部外用治療原發(fā)性皮膚淀粉樣變病臨床療效較好,中長(zhǎng)期使用(1~2個(gè)月)療效優(yōu)于單用鹵米松治療,且不良反應(yīng)輕微。
[Abstract]:Objective to investigate the clinical efficacy and safety of Runzao Zhiyang capsule combined with halomethasone ointment in the treatment of primary cutaneous amyloidosis. Methods 129 patients with primary cutaneous amyloidosis were randomly divided into treatment group and control group. 68 patients in treatment group were given Runzao Zhiyang capsule and halomisone ointment for topical use. The control group (61 cases) was treated with halomethasone for external use only. Symptom scores, efficacy and safety were evaluated at the end of the 4th and 8th week of treatment. Results at the end of the second week of treatment, the effective rates of the treatment group and the control group were 47.06% and 45.90%, respectively. There was no significant difference between the two groups (P0.05). At the end of the 4th and 8th week, the effective rate of the treatment group was 69.12% and 83.82%, the control group was 55.74% and 62.30%, the difference between the two groups was statistically significant (P0.05). There were only minor adverse reactions in both groups. Conclusion the clinical efficacy of Runzao Zhiyang capsule combined with halomethasone ointment in treating primary cutaneous amyloidosis is better than that of halomethasone alone in the long term (1 ~ 2 months), and the adverse reaction is slight.
【作者單位】： 西寧市第二人民醫(yī)院;
【分類(lèi)號(hào)】：R758.6

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