【摘要】：目的檢測白癜風(fēng)患者外周血CD4~+、CD8~+T細(xì)胞及CD4~+CD25~+調(diào)節(jié)性T細(xì)胞(Treg)的水平,同時(shí)對退白顆粒聯(lián)合NB-UVB治療后兩者的水平進(jìn)行檢測,探討兩者與該病的關(guān)系。方法采用流式細(xì)胞儀對120例白癜風(fēng)患者及30例健康對照組外周血CD4~+、CD8~+T細(xì)胞及CD4~+CD25~+Treg細(xì)胞水平進(jìn)行檢測,同時(shí)120例患者分為3組,各40例。聯(lián)合治療組采用退白顆粒聯(lián)合NB-UVB治療、對照Ⅰ組采用單獨(dú)NB-UVB治療,對照Ⅱ組采用退白顆粒治療,療程為3月,對3組患者治療前后CD4~+/CD8~+比值及CD4~+CD25~+Treg水平與健康對照組進(jìn)行比較。結(jié)果白癜風(fēng)患者外周血CD4~+T淋巴細(xì)胞明顯降低,而CD8~+T淋巴細(xì)胞則明顯升高,與健康對照組比較均有統(tǒng)計(jì)學(xué)差異(P0.01);進(jìn)展期患者CD4~+/CD8~+比值明顯低于穩(wěn)定期(P0.01),穩(wěn)定期與健康對照組比較無統(tǒng)計(jì)學(xué)差異(P0.05);白癜風(fēng)患者CD4~+CD25~+Treg細(xì)胞百分率明顯低于健康對照組(P0.01),且進(jìn)展期患者CD4~+CD25~+Treg細(xì)胞比穩(wěn)定期下降更明顯(P0.01)。采用退白顆粒聯(lián)合NB-UVB治療后CD4~+/CD8~+比值及CD4~+CD25~+Treg明顯上調(diào),與單獨(dú)NB-UVB和單獨(dú)退白顆粒治療比較,差異有顯著性意義(P0.01或P0.05)。結(jié)論 CD4~+/CD8~+比值的失衡與CD4~+CD25~+Treg數(shù)量的異�？赡軈⑴c了白癜風(fēng)的發(fā)病,退白顆粒聯(lián)合NB-UVB可能通過調(diào)節(jié)兩者的水平對該病發(fā)揮治療作用。
[Abstract]:Objective to detect the levels of CD4~, CD8~ T cells and CD4~ CD25~ regulatory T cell (Treg) in peripheral blood of patients with vitiligo. Methods the levels of CD4~, CD8~ T cells and CD4~ CD25~ Treg cells in peripheral blood of 120 patients with vitiligo and 30 healthy controls were measured by flow cytometry. The combined treatment group was treated with Tubai granule combined with NB-UVB, the control group was treated with NB-UVB alone, and the control group 鈪，

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