【摘要】：目的觀察異維A酸聯(lián)合阿奇霉素對青春期后中重度痤瘡的臨床療效和安全性,以及其對患者體內(nèi)性激素水平的影響。方法將120例患者隨機分為對照組60例和試驗組60例。對照組予以局部外敷0.1%阿達帕林凝膠均勻涂抹患處(睡前清洗創(chuàng)面后敷用),qd,共4周。試驗組在對照組的基礎上,予以口服異維A酸膠囊,每次10 mg,qd+阿奇霉素顆粒,飯后2小時口服,每次0.2 g,qd(服3 d停4 d),共4周。比較2組患者臨床療效、療效指數(shù)及對血清睪酮、雌二醇、孕酮、催乳素(PRL)、促卵泡激素(FSH)、黃體生成素(LH)、性激素結(jié)合蛋白(SHBG)、硫酸脫氫表雄酮(DHEAS)的差異。結(jié)果治療后,試驗組和對照組的總有效率分別為96.67%(58/60例)和73.33%(44/60例),差異有統(tǒng)計學意義(P0.01)。試驗組和對照組的療效指數(shù)分別是79.68±11.34和53.46±14.17,差異有統(tǒng)計學意義(P0.01)。治療后,試驗組和對照組的血清雌二醇分別為(43.15±14.91),(35.87±18.43)pg·mL~(-1);FSH分別為(9.23±1.29),(8.95±2.21)mU·mL~(-1);LH分別為(7.81±0.32),(5.63±0.73)mU·mL~(-1);LH/FSH分別為0.86±0.28和0.73±0.31;睪酮分別為(1.27±0.06),(2.58±0.11)nmol·L~(-1);孕酮分別為(0.95±0.12),(1.19±0.23)ng·mL~(-1);PRL分別為(10.31±1.17),(14.53±1.09)ng·mL~(-1);SHBG分別為(51.32±18.71),(69.93±13.65)nmol·L~(-1);DHEAS分別為(169.85±28.41),(183.24±29.18)μg·dL~(-1),差異均有統(tǒng)計學意義(均P0.05)。試驗組和對照組的藥物不良反應主要有紅斑、脫屑、灼熱、瘙癢及干燥等癥狀,藥物不良反應發(fā)生率分別為23.33%(14/60例)和18.33%(11/60例),差異無統(tǒng)計學意義(P0.05)。結(jié)論異維A酸與阿奇霉素聯(lián)合用藥有良好的治療效果,可以有效地降低體內(nèi)性激素水平,縮短治療的時間。
[Abstract]:Objective to observe the clinical efficacy and safety of isotinic acid combined with azithromycin in the treatment of moderate and severe postpubertal acne and the effect of isotinic acid combined with azithromycin on sex hormone levels in patients. Methods 120 patients were randomly divided into control group (n = 60) and experimental group (n = 60). In the control group, 0.1% adalin-gel was applied to the affected area (after cleaning the wound before bedtime,), qd, was applied for 4 weeks). On the basis of the control group, the experimental group was given isotinic acid capsules, 10 mg,qd azithromycin granules, 2 hours after meals, 0.2 g / g QD (3 days and 4 d),) for 4 weeks. The clinical efficacy, efficacy index, serum testosterone, estradiol, progesterone, prolactin (PRL), follicle stimulating hormone (FSH), luteinizing hormone (LH),) -binding protein (SHBG), (SHBG),) and dehydroepiandrosterone (DHEAS) (DHEAS) were compared between the two groups. Results after treatment, the total effective rates of the experimental group and the control group were 96.67% (58 / 60 cases) and 73.33% (44 / 60 cases), respectively. The difference was statistically significant (P0.01). The curative index of the experimental group and the control group were 79.68 鹵11.34 and 53.46 鹵14.17, respectively. The difference was statistically significant (P0.01). 娌葷枟鍚，

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