血清DHEA-S、PRL水平與慢性蕁麻疹關(guān)系的Meta分析
發(fā)布時(shí)間：2018-10-10 17:08
【摘要】：目的1.綜合評價(jià)血清硫酸去氫表雄酮(Dehydroepiandrosterone-Sulfate,DHEA-S)水平與慢性蕁麻疹(chronic urticaria,CU)的關(guān)系;2.綜合評價(jià)血清催乳素(prolactin,PRL)水平與慢性蕁麻疹的關(guān)系。方法1.應(yīng)用主題詞與自由詞相結(jié)合的檢索策略,計(jì)算機(jī)檢索英文數(shù)據(jù)庫Pub Med、Embase、Cochrane Library(2015年3期),中文數(shù)據(jù)庫萬方數(shù)據(jù)、CNKI、VIP、CBM,搜索有關(guān)血清DHEA-S水平與慢性蕁麻疹關(guān)系的病例-對照研究;2.應(yīng)用同樣的方法,檢索上述數(shù)據(jù)庫,搜索有關(guān)血清PRL水平與慢性蕁麻疹關(guān)系的病例-對照研究;3.檢索時(shí)限均設(shè)置為各數(shù)據(jù)庫從建庫至2017年2月;4.2名研究人員獨(dú)立進(jìn)行文獻(xiàn)篩選、資料提取、方法學(xué)質(zhì)量評價(jià);5.應(yīng)用Rev Man 5.3軟件包完成Meta分析、敏感性分析和發(fā)表偏倚風(fēng)險(xiǎn)評估。結(jié)果1.共納入12篇相關(guān)文獻(xiàn),包括14個(gè)研究;2.滿足血清DHEA-S水平與慢性蕁麻疹關(guān)系的病例對照研究有10個(gè);Meta分析結(jié)果顯示慢性蕁麻疹組較對照組DHEA-S水平低,差異有統(tǒng)計(jì)學(xué)意義[SMD=-0.94,95%CI(-1.09,-0.80),P0.00001];根據(jù)DHEA-S測量方法的不同進(jìn)行亞組分析,均顯示慢性蕁麻疹組較對照組DHEA-S水平低,差異有統(tǒng)計(jì)學(xué)意義[電化學(xué)發(fā)光免疫分析技術(shù)(electrochemiluminescence immunoassay,ECLIA):SMD=-0.73,95%CI(-0.94,-0.52),P0.00001;酶聯(lián)免疫吸附法(enzyme linked immunosorbent assay,ELISA):SMD=-0.59,95%CI(-0.87,-0.31),P0.0001;酶免疫測定法(enzyme immunoassay,EIA):SMD=-2.33,95%CI(-1.92,-1.37),P0.00001];依據(jù)性別不同進(jìn)行亞組分析,結(jié)果顯示男性、女性亞組,病例組較對照組DHEA-S水平均低,且差異有統(tǒng)計(jì)學(xué)意義[女性:SMD=-0.99,95%CI(-1.20,-0.78),P0.00001;男性:SMD=-0.65,95%CI(-0.96,-0.33),P0.0001];依據(jù)女性生理時(shí)期不同,分為絕經(jīng)期前和絕經(jīng)期后兩個(gè)亞組進(jìn)行分析,結(jié)果顯示僅絕經(jīng)期前人群慢性蕁麻疹患者DHEA-S水平較對照組低,差異有統(tǒng)計(jì)學(xué)意義,而絕經(jīng)期后人群,未見明顯差異[絕經(jīng)期前:SMD=-1.17,95%CI(-1.40,-0.94),P0.00001;絕經(jīng)期后:SMD=-0.13,95%CI(-0.62,0.37),P=0.62];3.滿足血清PRL水平與慢性蕁麻疹關(guān)系的病例對照研究有4個(gè);Meta分析結(jié)果顯示慢性蕁麻疹組較對照組PRL水平高,差異有統(tǒng)計(jì)學(xué)意義[SMD=0.45,95%CI(0.21,0.70),P=0.0002];4.敏感性分析結(jié)果顯示該結(jié)果穩(wěn)定、可靠;5.漏斗圖顯示存在發(fā)表偏倚。結(jié)論1.血清低水平的DHEA-S可能與慢性蕁麻疹的發(fā)生有關(guān);2.在女性人群中,血清高水平的PRL可能與慢性蕁麻疹的發(fā)生有關(guān);3.受當(dāng)前研究類型、質(zhì)量和數(shù)量的限制,上述結(jié)論仍需進(jìn)一步開展多中心大樣本高質(zhì)量的研究加以證實(shí)。
[Abstract]:Objective 1. To evaluate the relationship between serum dehydroepiandrosterone (Dehydroepiandrosterone-Sulfate,DHEA-S) level and chronic urticaria (chronic urticaria,CU). 2. To evaluate the relationship between serum prolactin (prolactin,PRL) level and chronic urticaria. Method 1. Using the search strategy of combining the subject word with the free word, the computer search English database Pub Med,Embase,Cochrane Library (2015 issue 3), the Chinese database Wanfang data, the CNKI,VIP,CBM, search about the serum DHEA-S level and the chronic urticaria relation case-control study; 2. The same method was used to search the above database and search the case-control study on the relationship between serum PRL level and chronic urticaria. The retrieval time limit was set for each database from the establishment of the database to February 2017; 4.2 researchers independently carried out literature screening, data extraction, methodological quality evaluation; 5. Meta analysis, sensitivity analysis and published bias risk assessment were performed with Rev Man 5.3 software package. Result 1. A total of 12 related articles, including 14 studies, were included. There were 10 case-control studies satisfying the relationship between serum DHEA-S level and chronic urticaria, and Meta analysis showed that the DHEA-S level of chronic urticaria group was lower than that of control group [SMD=-0.94,95%CI (-1.09- 0.80), P0.00001]. The levels of DHEA-S in chronic urticaria group were significantly lower than those in control group [electrochemiluminescence immunoassay (electrochemiluminescence immunoassay,ECLIA): SMD=-0.73,95%CI (-0.94- 0.52), P0.00001; enzyme-linked immunosorbent assay (enzyme linked immunosorbent assay,ELISA): SMD=-0.59,95%CI (-0.87- 0.31), P0.0001; Enzyme-immunoassay (enzyme immunoassay,EIA): SMD=-2.33,95%CI (-1.92h-1.37), P0.00001]; The results showed that the level of DHEA-S in male, female subgroup and case group was lower than that in control group, and the difference was statistically significant [female: SMD=-0.99,95%CI (-1.20 -0.78), P0.00001; male: SMD=-0.65,95%CI (-0.96ng-0.33), P0.0001]; according to the physiological period of female, it was divided into two subgroups: premenopausal group and postmenopausal subgroup. The results showed that the level of DHEA-S in patients with chronic urticaria was significantly lower than that in the control group only before menopause, but there was no significant difference in postmenopausal population [pre-menopause: SMD=-1.17,95%CI (-1.40- 0.94), P0.00001; postmenopausal: SMD=-0.13,95%CI (-0.62n0.37), P0.62]; There were 4 case-control studies satisfying the relationship between serum PRL level and chronic urticaria, and Meta analysis showed that the PRL level of chronic urticaria group was higher than that of control group, and the difference was statistically significant [SMD=0.45,95%CI (0.21 鹵0.70), P < 0.0002]; 4. The results of sensitivity analysis showed that the results were stable and reliable. The funnel diagram shows the existence of publication bias. Conclusion 1. The low level of serum DHEA-S may be related to the occurrence of chronic urticaria. In the female population, the high level of serum PRL may be associated with the occurrence of chronic urticaria; 3. Due to the limitations of current research types, quality and quantity, the above conclusions need to be confirmed by further multi-center, large sample and high quality studies.
【學(xué)位授予單位】：青島大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R758.24
本文編號(hào)：2262598
[Abstract]:Objective 1. To evaluate the relationship between serum dehydroepiandrosterone (Dehydroepiandrosterone-Sulfate,DHEA-S) level and chronic urticaria (chronic urticaria,CU). 2. To evaluate the relationship between serum prolactin (prolactin,PRL) level and chronic urticaria. Method 1. Using the search strategy of combining the subject word with the free word, the computer search English database Pub Med,Embase,Cochrane Library (2015 issue 3), the Chinese database Wanfang data, the CNKI,VIP,CBM, search about the serum DHEA-S level and the chronic urticaria relation case-control study; 2. The same method was used to search the above database and search the case-control study on the relationship between serum PRL level and chronic urticaria. The retrieval time limit was set for each database from the establishment of the database to February 2017; 4.2 researchers independently carried out literature screening, data extraction, methodological quality evaluation; 5. Meta analysis, sensitivity analysis and published bias risk assessment were performed with Rev Man 5.3 software package. Result 1. A total of 12 related articles, including 14 studies, were included. There were 10 case-control studies satisfying the relationship between serum DHEA-S level and chronic urticaria, and Meta analysis showed that the DHEA-S level of chronic urticaria group was lower than that of control group [SMD=-0.94,95%CI (-1.09- 0.80), P0.00001]. The levels of DHEA-S in chronic urticaria group were significantly lower than those in control group [electrochemiluminescence immunoassay (electrochemiluminescence immunoassay,ECLIA): SMD=-0.73,95%CI (-0.94- 0.52), P0.00001; enzyme-linked immunosorbent assay (enzyme linked immunosorbent assay,ELISA): SMD=-0.59,95%CI (-0.87- 0.31), P0.0001; Enzyme-immunoassay (enzyme immunoassay,EIA): SMD=-2.33,95%CI (-1.92h-1.37), P0.00001]; The results showed that the level of DHEA-S in male, female subgroup and case group was lower than that in control group, and the difference was statistically significant [female: SMD=-0.99,95%CI (-1.20 -0.78), P0.00001; male: SMD=-0.65,95%CI (-0.96ng-0.33), P0.0001]; according to the physiological period of female, it was divided into two subgroups: premenopausal group and postmenopausal subgroup. The results showed that the level of DHEA-S in patients with chronic urticaria was significantly lower than that in the control group only before menopause, but there was no significant difference in postmenopausal population [pre-menopause: SMD=-1.17,95%CI (-1.40- 0.94), P0.00001; postmenopausal: SMD=-0.13,95%CI (-0.62n0.37), P0.62]; There were 4 case-control studies satisfying the relationship between serum PRL level and chronic urticaria, and Meta analysis showed that the PRL level of chronic urticaria group was higher than that of control group, and the difference was statistically significant [SMD=0.45,95%CI (0.21 鹵0.70), P < 0.0002]; 4. The results of sensitivity analysis showed that the results were stable and reliable. The funnel diagram shows the existence of publication bias. Conclusion 1. The low level of serum DHEA-S may be related to the occurrence of chronic urticaria. In the female population, the high level of serum PRL may be associated with the occurrence of chronic urticaria; 3. Due to the limitations of current research types, quality and quantity, the above conclusions need to be confirmed by further multi-center, large sample and high quality studies.
【學(xué)位授予單位】：青島大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R758.24
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