伴有ALK基因融合的Spitz痣、非典型Spitz腫瘤的臨床病理學(xué)特征
發(fā)布時(shí)間:2018-08-31 18:54
【摘要】:正Spitz腫瘤是一組發(fā)生于青年人,主要由梭形及上皮樣腫瘤細(xì)胞組成的黑色素細(xì)胞腫瘤。Spitz黑色素腫瘤包括良性的Spitz痣,惡性潛能未定的非典型Spitz腫瘤和Spitz樣惡性黑色素瘤。目前通過(guò)皮膚病理學(xué)形態(tài)上鑒別惰性病變或是侵襲性致命腫瘤仍是一個(gè)難題。有研究表明,Spitz腫瘤存在包括ALK基因融合在內(nèi)的多種基因融合,且這些基因融合腫瘤具有特定的臨床病理特點(diǎn)。為此作者對(duì)17例伴有
[Abstract]:Positive Spitz tumor is a group of melanocytic neoplasms mainly composed of fusiform and epithelioid tumor cells. Spitz melanoma includes benign Spitz nevus, atypical Spitz tumor with uncertain malignant potential and Spitz like malignant melanoma. At present, it is still a difficult problem to distinguish inert lesions or aggressive and fatal tumors by skin pathology. There are many kinds of gene fusion including ALK gene fusion in Spitz tumors, and these fusion tumors have specific clinicopathological characteristics. For this reason, the authors report 17 cases with
【作者單位】: 解放軍第180醫(yī)院;南京軍區(qū)福州總醫(yī)院;
【分類(lèi)號(hào)】:R739.5
本文編號(hào):2215864
[Abstract]:Positive Spitz tumor is a group of melanocytic neoplasms mainly composed of fusiform and epithelioid tumor cells. Spitz melanoma includes benign Spitz nevus, atypical Spitz tumor with uncertain malignant potential and Spitz like malignant melanoma. At present, it is still a difficult problem to distinguish inert lesions or aggressive and fatal tumors by skin pathology. There are many kinds of gene fusion including ALK gene fusion in Spitz tumors, and these fusion tumors have specific clinicopathological characteristics. For this reason, the authors report 17 cases with
【作者單位】: 解放軍第180醫(yī)院;南京軍區(qū)福州總醫(yī)院;
【分類(lèi)號(hào)】:R739.5
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1 Morgan C.J.;Nyak N.;Cooper A.;馮義國(guó);;多發(fā)性Spitz痣:2例報(bào)道及臨床和組織病理分析[J];世界核心醫(yī)學(xué)期刊文摘(皮膚病學(xué)分冊(cè));2006年05期
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