發(fā)布時(shí)間：2018-07-25 15:48

【摘要】：目的通過(guò)對(duì)346例中重度尋常型銀屑病患者進(jìn)行問(wèn)卷調(diào)查及相關(guān)化驗(yàn)檢查,了解銀屑病發(fā)病的一般規(guī)律,并探討代謝綜合征與銀屑病病程、嚴(yán)重程度及患者年齡的相關(guān)性。方法收集2016年3月-2017年1月間在天津市中醫(yī)藥研究院附屬醫(yī)院皮膚科門(mén)診及病房接受治療的中重度尋常型銀屑病患者,以PASI評(píng)分法確定疾病的嚴(yán)重程度,然后采用問(wèn)卷調(diào)查及化驗(yàn)檢查相結(jié)合的方法對(duì)患者一般情況及代謝相關(guān)指標(biāo)進(jìn)行統(tǒng)計(jì)填表,調(diào)查表中的內(nèi)容經(jīng)EXCEL2007軟件進(jìn)行分類整理,所有記錄數(shù)據(jù)經(jīng)SPSS21.0軟件進(jìn)行統(tǒng)計(jì)分析。結(jié)果1.一般資料:346例中重度尋常型銀屑病患者中男性220例,女性126例,男女之比為1.75:1,男性多于女性;PASI評(píng)分最低10.6分,最高37分,平均(17.10±3.728)分,其中10PASI≤15組127人,15PASI≤20組151人,PASI20組68人;銀屑病患者以中青年為主,發(fā)病高峰集中在35-50歲,男性發(fā)病集中在31-40歲,女性發(fā)病集中在21-30歲;病程以5年以上居多,并且以反復(fù)發(fā)作最常見(jiàn);職業(yè)分布上以退休人員,工人及農(nóng)民所占比例最高,其次為學(xué)生;初發(fā)季節(jié)以春秋季為主,復(fù)發(fā)或加重常見(jiàn)于冬季;初次發(fā)病部位可累及全身,但以頭皮多發(fā),其次為肘部和小腿;有86.13%的患者伴有瘙癢癥狀,以輕中度瘙癢為主;誘發(fā)因素中感染(上呼吸道感染)最常見(jiàn),其次為情志因素;有銀屑病家族史者平均首次發(fā)病年齡早于無(wú)家族史者,對(duì)于有家族史的患者,女性患者平均首次發(fā)病年齡早于男性患者,經(jīng)統(tǒng)計(jì)學(xué)檢驗(yàn),差異均有顯著性(p0.05)。2.合并代謝綜合征的情況:346例銀屑病患者中符合代謝綜合征診斷標(biāo)準(zhǔn)的有107人,占30.92%,其中超重或肥胖、高血糖或已確診糖尿病、血壓升高或已確診高血壓、甘油三酯升高和高密度脂蛋白膽固醇降低的發(fā)生率分別為47.11%、10.69%、28.32%、37.86%和42.49%;銀屑病患者代謝綜合征的患病率與患者年齡呈正相關(guān),與銀屑病嚴(yán)重程度也呈正相關(guān),經(jīng)檢驗(yàn),差異均有統(tǒng)計(jì)學(xué)意義(p0.05),但與銀屑病病程無(wú)明顯相關(guān)關(guān)系(p0.05)。結(jié)論1.銀屑病具有遺傳傾向,有家族史的患者初發(fā)年齡早于無(wú)家族史者,而有家族史的患者中女性初發(fā)年齡早于男性。2.銀屑病患者代謝綜合征的患病率明顯高于一般人群。3.代謝綜合征的患病率與銀屑病患者年齡以及病情嚴(yán)重程度之間呈正相關(guān)關(guān)系。4.代謝綜合征的患病率與銀屑病病程之間無(wú)明顯相關(guān)關(guān)系。
[Abstract]:Objective to investigate the general regularity of psoriasis and the correlation between metabolic syndrome and the course, severity and age of psoriasis by questionnaire and laboratory examination in 346 patients with moderate and severe psoriasis vulgaris. Methods patients with moderate and severe psoriasis vulgaris were collected from March 2016 to January 2017 in the dermatology department of affiliated Hospital of Tianjin Academy of traditional Chinese Medicine, and the severity of the disease was determined by PASI score. Then the general situation of patients and metabolic related indexes were statistically filled out by means of questionnaire and laboratory examination. The contents of the questionnaire were classified by EXCEL2007 software and all recorded data were statistically analyzed by SPSS21.0 software. Result 1. General data: among the 346 moderate and severe psoriasis patients, 220 were male and 126 were female. The ratio of male to female was 1.75: 1. The lowest score was 10.6, the highest score was 37, the average score was (17.10 鹵3.728) in male than female. The average score was (17.10 鹵3.728) in 10PASI 鈮，

本文編號(hào)：2144296