發(fā)布時(shí)間：2018-07-20 09:15

【摘要】：目的探討CSMD1基因多態(tài)性rs7007032與漢族人尋常型銀屑病一些臨床表型(家族史、發(fā)病年齡及皮損類型)的相關(guān)性。方法結(jié)合本課題組銀屑病易感基因的全基因組關(guān)聯(lián)分析數(shù)據(jù),選取7 318例銀屑病患者和11 290例正常對照的CSMD1基因多態(tài)性rs7007032基因分型資料,SPSS 16.0軟件對數(shù)據(jù)資料進(jìn)行統(tǒng)計(jì)分析,χ2檢驗(yàn)用于比較各組間rs7007032等位基因頻率分布。結(jié)果在病例組與對照組之間,CSMD1基因多態(tài)性rs7007032等位基因頻率分布差異有統(tǒng)計(jì)學(xué)意義(P=9.24×10-9),各臨床表型亞組分別與對照組比較,rs7007032等位基因頻率分布差異均具有統(tǒng)計(jì)學(xué)意義(P1.0×10-4)。在家族史陽性和陰性患者之間、少兒發(fā)病和成人發(fā)病患者之間,rs7007032等位基因頻率分布差異均有統(tǒng)計(jì)學(xué)意義(P0.05);在急性點(diǎn)滴型和慢性斑塊型患者之間,rs7007032等位基因頻率分布差異無統(tǒng)計(jì)學(xué)意義。結(jié)論 CSMD1基因多態(tài)性rs7007032與漢族人尋常型銀屑病發(fā)病的易感性相關(guān),此外還與該疾病的家族史和發(fā)病年齡相關(guān),但與皮損的臨床類型不相關(guān)。
[Abstract]:Objective to investigate the association of CSMD1 gene polymorphism rs7007032 with some clinical phenotypes (family history, age of onset and type of skin lesion) of psoriasis vulgaris in Han nationality. Methods Genome-wide association analysis data of psoriasis susceptibility genes were analyzed. The polymorphism rs7007032 genotyping data of CSMD1 gene in 7 318 patients with psoriasis and 11 290 normal controls were statistically analyzed by SPSS16.0 software. 蠂 2 test was used to compare the frequency distribution of rs7007032 alleles among groups. Results the frequency distribution of rs7007032 allele of CSMD1 gene polymorphism was significantly different between the case group and the control group (P9.24 脳 10-9). The allele frequencies of rs7007032 in each clinical phenotypic subgroup were significantly different from those in the control group (P1.0 脳 10-4). Between positive and negative family history patients, The allele frequencies of rs7007032 were significantly different between children and adults (P0.05), but there was no significant difference in the frequency distribution of rs7007032 between acute plaque patients and chronic plaque patients. Conclusion CSMD1 polymorphism rs7007032 is associated with susceptibility to psoriasis vulgaris, family history and age, but not with clinical type of skin lesions.
【作者單位】： 安徽醫(yī)科大學(xué)第一附屬醫(yī)院皮膚病研究所;皮膚病學(xué)國家重點(diǎn)實(shí)驗(yàn)室培育基地;安徽醫(yī)科大學(xué)皮膚病與性病學(xué)系;
【基金】：國家自然科學(xué)基金項(xiàng)目(編號:30800990,81072461,31000528,30800610)
【分類號】：R758.63

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