本文選題：黑色素瘤細(xì)胞 + 微直流電場(chǎng)�。� 參考：《中國(guó)細(xì)胞生物學(xué)學(xué)報(bào)》2014年06期

【摘要】：微小直流電場(chǎng)具有指導(dǎo)細(xì)胞進(jìn)行定向遷移的作用。各種細(xì)胞外基質(zhì)的物理、化學(xué)性質(zhì)會(huì)影響細(xì)胞的遷移。該研究以小鼠皮膚黑色素瘤細(xì)胞(B16-F10)為模型,比較微直流電場(chǎng)(250 mV/mm)指導(dǎo)下細(xì)胞在平滑基底與兩種不同市售基質(zhì)Matrigel及FNC上的趨電性。結(jié)果顯示,黑色素瘤細(xì)胞在三種基底上均有明顯的向電場(chǎng)陰極遷移的趨電運(yùn)動(dòng),但在不同基質(zhì)上細(xì)胞趨電的方向性無顯著差異,但細(xì)胞遷移速度及在細(xì)胞沿電場(chǎng)進(jìn)行定向遷移的持續(xù)性有顯著差異。
[Abstract]:The micro DC field has the function of directing cell migration. The physical and chemical properties of various extracellular matrices affect cell migration. In this study, mouse skin melanoma cells (B16-F10) were used as a model to compare the electrophilic properties of mouse skin melanoma cells on smooth substrate and two different marketable matrix Matrigel and FNC under the guidance of micro-direct current electric field (250 MV / mm). The results showed that melanoma cells had obvious electrophilic migration to the electric field cathode on all three substrates, but there was no significant difference in the electrophilic direction of melanoma cells on different substrates. However, there were significant differences in cell migration speed and the persistence of directional migration along the electric field.
【作者單位】： 云南師范大學(xué)再生生物學(xué)實(shí)驗(yàn)室;美國(guó)加州大學(xué)戴維斯分校醫(yī)學(xué)院再生治療研究所;
【基金】：云南省高端科技人才引進(jìn)項(xiàng)目(批準(zhǔn)號(hào):2009CI127) 教育部留學(xué)回國(guó)人員科研啟動(dòng)基金資助項(xiàng)目 教育部春暉計(jì)劃資助的課題~~
【分類號(hào)】：R739.5

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