本文選題：膨脹紋 + 點陣激光　； 參考：《復(fù)旦大學(xué)》2011年碩士論文

【摘要】：【背景】膨脹紋是主要發(fā)生于全身的張力部位的萎縮性條索,尋找安全又有效的治療方法是現(xiàn)在目前研究的主要方向。 【目的】了解點陣激光對中國人膨脹紋的治療作用并尋找合適治療參數(shù),建立合理的治療方案,提高療效的同時減少副作用的發(fā)生。 【方法】共招募60例軀干四肢膨脹紋患者,其中43名女性,17名男性。使用點陣激光進行治療。采用隨機數(shù)碼表隨機分為3組。分為對照組、ActiveFX及DeepFX組。每位受試者接收1次至3次的治療�；�時、每次治療前以及每次隨訪時由三名不參與治的皮膚科臨床醫(yī)生單獨對受試者進行膨脹紋的評分并以數(shù)碼相機記錄等,并記錄療效情況、不良反應(yīng)發(fā)生情況及受試者對治療效果進行自評。對病例的治療前和治療后皮損進行反射式共聚焦顯微鏡(Reflectance confocal microscopy, RCM)檢測,并對兩名患者進行治療前及治療后1個月的免疫組化。 【結(jié)果】60名病例完成治療及隨訪。根據(jù)每位患者在基線時及末次治療后3個月隨訪時作出的評價發(fā)現(xiàn),對治療組和對照組分析結(jié)果表明,治療組在總體改善、皮膚粗糙度方面均與對照組有顯著性差異(P0.01)。而DeepFX與對照組相比較,在皮膚深度上有顯著性差異(P0.01)。將ActiveFX與DeepFX兩組比較療效,發(fā)現(xiàn)他們之間存在顯著性差異,而在粗糙度、皮膚深度兩項有統(tǒng)計學(xué)意義(P0.05)。患者的滿意度自評結(jié)果提示治療組與對照組均有顯著性差異(P0.01)。將ActiveFX與DeepFX兩組比較后存在顯著性差異。SD分型分析后發(fā)現(xiàn)各組間差異存在統(tǒng)計學(xué)意義(P0.05),激光治療對Ⅰ型及Ⅵ型SD均有良好的臨床療效。治療次數(shù)為3次的病人其預(yù)后最佳,組間存在差異。治療組與對照組相比色素沉著上有顯著性差異(P0.01)。兩組治療組比較下來DeepFX疼痛度較ActiveFX明顯。RCM檢測示治療后在1周可見毛細(xì)血管擴張、水腫等炎性反應(yīng),1個月后可見到膠原纖維呈網(wǎng)狀排列。免疫組化結(jié)果示SD因治療后組織真皮增厚、毛細(xì)血管擴張及水腫等炎性反應(yīng)。膠原蛋白Ⅰ及膠原蛋白Ⅲ在治療后染色呈陽性。DeepFX方法在總體改善、粗糙度及皮膚深度等評價均較ActiveFX為佳�；颊叩臐M意度自評結(jié)果提示治療組的滿意度均高于對照組,其中DeepFX治療的患者滿意度最高。激光治療對Ⅰ型及Ⅵ型的SD有明顯的臨床療效。治療3次的病人其預(yù)后最佳,副作用評價顯示,ActiveFX及DeepFX均可見輕度色素沉著的表現(xiàn),DeepFX疼痛度較ActiveFX明顯。點陣激光能安全又有效的治療膨脹紋。
[Abstract]:[background] expansion lines are atrophic strips that mainly occur in the tension part of the body. To find a safe and effective treatment method is the main research direction at present. [objective] to understand the therapeutic effect of dot array laser on swelling stria in Chinese, to find out the appropriate treatment parameters, and to establish a reasonable treatment plan. [methods] A total of 60 patients with swelling marks of trunk and extremities were recruited, including 43 women and 17 men. A dot array laser was used to treat the patients. A random code list was used to divide the data into 3 groups. They were divided into two groups: active FX and DeepFX groups. Each subject received one to three treatments. At baseline, before each treatment and at each follow-up, three dermatologists who were not involved in the treatment separately scored the swelling lines on the subjects and recorded them with digital cameras, and recorded the curative effects. Adverse reactions and self-evaluation of the therapeutic effect were carried out. Reflectance confocal microscopy (RCM) was used to detect the skin lesions before and after treatment, and immunohistochemical staining was performed on two patients before and one month after treatment. [results] 60 cases were treated and followed up. According to the evaluation of each patient at baseline and 3 months after the last treatment, the results of analysis of treatment group and control group showed that there were significant differences in overall improvement and skin roughness between the treatment group and the control group (P0.01). Compared with the control group, DeepFX had a significant difference in skin depth (P0.01). Comparing the efficacy of active FX and DeepFX, we found that there were significant differences between them, but there were significant differences in roughness and skin depth (P0.05). The results of self-evaluation of patients' satisfaction indicated that there was significant difference between the treatment group and the control group (P0.01). There was significant difference between active FX group and DeepFX group. SD typing analysis showed that there was significant difference between the two groups (P0.05). Laser therapy had good clinical effect on type 鈪，

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