本文選題：鱗狀細(xì)胞癌 + p��； 參考：《中國(guó)皮膚性病學(xué)雜志》2017年09期

【摘要】：目的探討p16蛋白和增殖細(xì)胞核抗原(PCNA)在鱗狀細(xì)胞癌組織中的表達(dá)及其與臨床病理特征的關(guān)系。方法利用免疫組織化學(xué)法(IHC)檢測(cè)50例鱗狀細(xì)胞癌患者的癌組織、癌旁組織和30例健康人群的正常組織中p16蛋白和PCNA的表達(dá)情況,并分析p16蛋白和PCNA與鱗狀細(xì)胞癌臨床病理特征的關(guān)系。結(jié)果鱗狀細(xì)胞癌組織中p16蛋白陽(yáng)性表達(dá)率顯著低于癌旁組織和正常組織(P0.01),鱗狀細(xì)胞癌組織中PCNA指數(shù)顯著高于癌旁組織和正常組織(P0.01);p16蛋白陽(yáng)性表達(dá)率隨著癌組織浸潤(rùn)深度增加而降低(P0.01),PCNA指數(shù)隨著癌組織浸潤(rùn)深度增加而增大(P0.01);PTNMⅠ~Ⅱ期p16蛋白陽(yáng)性表達(dá)率顯著高于PTNMⅢ~Ⅳ期(P0.01),PTNMⅠ~Ⅱ期PCNA指數(shù)顯著低于PTNMⅢ~Ⅳ期(P0.01);p16陽(yáng)性表達(dá)的鱗狀細(xì)胞癌組織中PCNA指數(shù)為30.67±9.82,顯著低于p16陰性表達(dá)的鱗狀細(xì)胞癌組織中的51.96±12.43(P0.01)。結(jié)論在鱗狀細(xì)胞癌組織中p16蛋白缺失,而PCNA大量表達(dá),且p16蛋白和PCNA表達(dá)與鱗狀細(xì)胞癌的病理分期和浸潤(rùn)深度密切相關(guān),提示p16蛋白和PCNA可作為評(píng)價(jià)鱗狀細(xì)胞癌病變程度的重要指標(biāo),對(duì)指導(dǎo)治療鱗狀細(xì)胞癌有重大意義。
[Abstract]:Objective to investigate the expression of p16 protein and proliferating cell nuclear antigen (PCNA) in squamous cell carcinoma (SCC) and their relationship with clinicopathological features. Methods Immunohistochemical assay (IHC) was used to detect the expression of p16 protein and PCNA in cancer tissues of 50 patients with squamous cell carcinoma, adjacent tissues and 30 healthy controls. The relationship between p16 protein and PCNA and clinicopathological features of squamous cell carcinoma was analyzed. Results the positive expression rate of p16 protein in squamous cell carcinoma tissues was significantly lower than that in adjacent tissues and normal tissues (P0.01). The PCNA index in squamous cell carcinoma tissues was significantly higher than that in paracancerous tissues and normal tissues (P0.01). The positive rate of p16 protein expression in PTNM 鈪，

本文編號(hào)：2070781