本文選題：頭皮脂溢性皮炎 + 白柳皮萃取精華　； 參考：《吉林大學》2017年碩士論文

【摘要】：背景頭皮脂溢性皮炎是一種較常見的慢性炎癥性皮膚病,病因及發(fā)病機制尚未完全清楚。研究發(fā)現(xiàn)與馬拉色菌的定植感染、油脂分泌水平、機體免疫狀態(tài)、年齡、氣候條件等因素息息相關�？拐婢委熓侵委燁^皮脂溢性皮炎的常用方法。Draelos ZD等,選取363例頭皮脂溢性皮炎患者,予2%酮康唑洗發(fā)劑外用,每周2次,療程1個月,患者臨床癥狀均得到不同程度的改善,僅少數(shù)患者出現(xiàn)局部刺激癥狀,但均可耐受,證明酮康唑洗發(fā)劑療效確切,可用來治療頭皮脂溢性皮炎,且安全性好,患者易于接受。硫氧吡啶鋅亦是一種常用的抗真菌有效成分,于上世紀50年代被發(fā)現(xiàn)以來,含1%硫氧吡啶鋅有效成分洗發(fā)劑,廣泛用于治療頭皮脂溢性皮炎。由于硫氧吡啶鋅具有抗真菌活性機制,且硫氧吡啶鋅活性成分可在毛囊深部較長時間沉積和停留,故而起到持久、深部殺菌作用。研究表明:含2%酮康唑或1%硫氧吡啶鋅有效抗菌成分的洗發(fā)劑療效確切。近年來,隨著我國中醫(yī)中藥的發(fā)展,人們對中草藥抗真菌作用日益關注。Braga PC等報道白柳皮萃取精華、百里香花葉油對念珠菌有抑菌作用,但對馬拉色菌是否有抑制作用未見文獻報道。本文擬采用隨機雙盲對照試驗觀察含白柳皮萃取精華、百里香花葉油成分的植物洗發(fā)劑對頭皮脂溢性皮炎的療效,以便為臨床應用提供依據(jù)。目的探討植物洗發(fā)劑(含白柳皮萃取精華、百里香花葉油成分)治療頭皮脂溢性皮炎的臨床療效及其對皮損處分離的馬拉色菌體外抗真菌活性。方法將自2015年10月-2016年3月,2016年10月-2016年12月就診于吉林大學中日聯(lián)誼醫(yī)院皮膚科門診,明確診斷為頭皮脂溢性皮炎的90例患者隨機分成3個治療組,分別為含2%酮康唑組,含1%硫氧吡啶鋅組,含白柳皮萃取精華、百里香花葉油有效成分的植物洗發(fā)劑組(以下簡稱植物洗發(fā)劑組),每組30例,所有患者均要求頭皮接觸洗發(fā)劑時間"g5分鐘后沖凈,適當按摩,每周3次,療程4周。各組性別、年齡、臨床嚴重程度評分均無統(tǒng)計學差異(P0.05)。于治療前、治療第2周、治療第4周,由同一皮膚科醫(yī)生評估臨床嚴重程度、經(jīng)皮水分丟失率、表皮含水量、p H值、油脂分泌水平等檢測項目。將自頭皮脂溢性皮炎患者分離、鑒定出的馬拉色菌制作成含菌平板,37℃培養(yǎng)7天后測定各洗發(fā)劑的抑菌圈半徑。結果植物洗發(fā)劑組臨床療效與含2%酮康唑、1%硫氧吡啶鋅的洗發(fā)劑臨床療效相當,且未見局部及全身不良反應。3種洗發(fā)劑對3種馬拉色菌均產(chǎn)生抑菌圈,以植物洗發(fā)劑組抑菌圈半徑最大,差異有統(tǒng)計學意義(P0.05)。結論含白柳皮萃取精華、百里香花葉油等有效成分的植物洗發(fā)劑,療效顯著,安全性高,使用方便,抑菌效果好,可用于臨床治療頭皮脂溢性皮炎。
[Abstract]:Background seborrheic dermatitis is a common chronic inflammatory dermatosis. It was found that Malassezia was closely related to colonization infection, lipid secretion level, immune status, age, climatic conditions and so on. Antifungal therapy is a common method for treating seborrheic dermatitis. Draelos ZD was used in 363 patients with seborrheic dermatitis. The patients were treated with 2% ketoconazole shampoo twice a week for one month. Only a few patients had local irritation symptoms, but were tolerable, which proved that ketoconazole shampoo was effective and safe in treating seborrheic dermatitis of scalp. Zinc thiopyridine is also a common antifungal active ingredient. Since its discovery in 1950s, 1% zinc thiopyridine shampoo has been widely used in the treatment of seborrheic dermatitis. Zinc thiopyridine has antifungal activity, and zinc thiopyridine can deposit and stay in the hair follicle for a long time, so it has a lasting and deep bactericidal effect. The results showed that the shampoo containing 2% ketoconazole or 1% zinc thiopyridine was effective. In recent years, with the development of traditional Chinese medicine in China, more and more attention has been paid to the antifungal effect of Chinese herbal medicine. Braga PC has reported that the extract of white willow peel and thyme mosaic oil have bacteriostatic effect on Candida. However, whether Malassezia has inhibitory effect has not been reported. In this paper, a randomized double-blind controlled trial was conducted to observe the therapeutic effect of plant shampoo containing extract of willow peel and thyme mosaic oil on seborrheic dermatitis of scalp in order to provide basis for clinical application. Objective to investigate the clinical efficacy of plant shampoo (including the extract of willow skin and thyme mosaic oil) in the treatment of seborrheic dermatitis and its antifungal activity against Malassezia isolated from skin lesions in vitro. Methods from October 2015 to March 2016, from October 2016 to December 2016, 90 patients with seborrheic dermatitis were randomly divided into 3 treatment groups, including 2% ketoconazole group. 1% thiopyridine zinc group, white willow skin extract, thyme mosaic oil active ingredient plant shampoo group (hereinafter referred to as plant shampoo group, 30 cases in each group), all patients required scalp contact shampoo time "g 5 minutes to rinse off," Massage 3 times a week for 4 weeks. There was no significant difference in gender, age and clinical severity score in all groups (P 0.05). Before treatment, 2 weeks and 4 weeks of treatment, the clinical severity, percutaneous water loss rate, skin moisture content and lipid secretion level were evaluated by the same dermatologist. Malassezia was isolated from patients with seborrheic dermatitis. The identified Malassezia was cultured at 37 鈩，

本文編號：2045380