本文選題：漢族 + 特應(yīng)性皮炎　； 參考：《安徽醫(yī)科大學》2011年碩士論文

【摘要】：研究背景特應(yīng)性皮炎(atopic dermatitis, AD)是一種慢性、炎癥性、反復發(fā)作性疾病,好發(fā)于嬰兒和兒童。很多大規(guī)模的AD流行病學調(diào)查是基于西方國家人群,而有關(guān)亞洲人群的研究較少。本研究對中國漢族3915例AD患者的流行病學特點和臨床特征進行回顧性分析。 目的研究中國漢族3915例特應(yīng)性皮炎患者的流行病學特點和臨床特征。 方法收集2008年1月至2010年3月來自全國多家合作醫(yī)院的3915例AD患者,均符合Hanifin-Rajka診斷標準。采用統(tǒng)一的問卷調(diào)查對病人及家屬進行臨床流行病學調(diào)查,應(yīng)用Epi info 6.0軟件和SPSS10.0軟件對資料進行統(tǒng)計學處理和分析,男性與女性組、發(fā)病年齡2歲(又稱早年發(fā)病組)和發(fā)病年齡≥2歲組的臨床特征方面的差異采用卡方檢驗。 結(jié)果3915例AD患者男女比為1.5:1(男2333例,女1582例),發(fā)病年齡中位數(shù)位為2月,84.6%的患者于出生后2年內(nèi)發(fā)病,且早年發(fā)病組中男性較女性多。家族特應(yīng)性病史陽性患者2778(71%)例,“單純型”AD 2267(57.9%)例,“混合型”AD 1684(42.1%)例,早年發(fā)病組中家族史陽性發(fā)生率高,而哮喘、過敏性鼻炎的發(fā)病率在早年發(fā)病組低(p均0.001)。本研究顯示,53.0%的患者病情存在季節(jié)差異性,其余47.0%的患者病情則無明顯季節(jié)差異性;84%的患者病情為輕到中度,男性病情較女性重(p0.05)。Hanifin-Rajka診斷標準的次要體征在AD患者中較常見的為干皮癥(78%)、出汗時瘙癢(64.9%)和蒼白臉/面部皮炎(58.4%);其他相關(guān)癥狀常見的為頭皮皮炎(44.1%)、耳廓下裂隙(33.9%)和慢性頭皮脫屑(22.6%)。蒼白臉/面部皮炎、頭皮皮炎、耳廓下裂隙、乳頭濕疹、干皮癥在早年發(fā)病組的發(fā)生率高,而眶周黑暈、白色糠疹、魚鱗病/毛周角化/掌紋癥、Dennie-Morgan眶下皺褶在發(fā)病年齡≥2歲組的發(fā)生率高(p均0.05)。另外,蒼白臉/面部皮炎、皮膚感染傾向、乳頭濕疹在男性中的發(fā)生率高于女性,而眶周黑暈、Dennie-Morgan眶下皺褶、魚鱗病/毛周角化/掌紋癥在女性中的發(fā)生率高(p均0.05)。 結(jié)論AD患者發(fā)病的流行病學特征、疾病嚴重程度及Hanifin-Rajka診斷標準中的部分次要體征在男性女性組及不同發(fā)病年齡組存在統(tǒng)計學差異,對中國漢族AD患者的診斷提供了線索和依據(jù)。
[Abstract]:Background atopic dermatitis (ADD) is a chronic, inflammatory and recurrent disease that occurs in infants and children. Many large-scale AD epidemiological surveys are based on Western populations, while less research has been done on Asian populations. The epidemiological and clinical features of 3915 AD patients in Chinese Han nationality were retrospectively analyzed. Objective to study the epidemiological and clinical characteristics of 3915 patients with atopic dermatitis in Chinese Han nationality. Methods from January 2008 to March 2010, 3915 AD patients from several cooperative hospitals in China were collected, all of whom were in accordance with the diagnostic criteria of Hanifin-Rajka. A unified questionnaire survey was used to investigate the clinical epidemiology of patients and their families. The data were statistically analyzed by Epi info 6.0 software and SPSS 10.0 software. Chi-square test was used for the difference of clinical characteristics between the onset age of 2 years old (also called early onset group) and the age of onset 鈮，

本文編號：2017073