本文選題：益肺健脾祛白方 + 兒童白癜風(fēng)　； 參考：《廣西中醫(yī)藥大學(xué)》2017年碩士論文

【摘要】：目的:觀察益肺健脾祛白方聯(lián)合窄譜中波紫外線(NB-UVB)治療兒童白癜風(fēng)前后的皮損面積及血清IL-17的變化,從而驗(yàn)證聯(lián)合治療的臨床療效,并探討兒童白癜風(fēng)與IL-17水平的關(guān)系。方法:遵循隨機(jī)對(duì)照原則,將66例兒童白癜風(fēng),按隨機(jī)數(shù)字表法分為治療組(益肺健脾祛白方聯(lián)合NB-UVB)32例和對(duì)照組(NB-UVB)34例。治療組予內(nèi)服益肺健脾祛白方聯(lián)合NB-UVB局部照射,對(duì)照組予NB-UVB,治療方法同治療組,兩組同時(shí)外用散寒活血祛白酊。1個(gè)月為一個(gè)療程,共3個(gè)療程。觀察記錄兩組治療前后皮損面積評(píng)分,并進(jìn)行臨床療效判定。同時(shí)采用ELISA法對(duì)兩組患兒治療前后外周血IL-17水平進(jìn)行檢測(cè),并比較治療前后IL-17水平的差異。結(jié)果:(1)本研究共有3例脫落病例,所納入實(shí)際病例為63例(治療組31例,對(duì)照組32例)。兩組患兒性別、年齡、病程、分期、分型比較,差異均無(wú)統(tǒng)計(jì)學(xué)意義(P0.05),具有可比性。(2)VASI評(píng)分比較:治療前治療組與對(duì)照組病情程度、VASI評(píng)分比較,差異均無(wú)統(tǒng)計(jì)學(xué)意義(P0.05),具有可比性。治療3個(gè)月后,兩組自身前后比較VASI評(píng)分均降低(P0.01);組間比較治療組VASI評(píng)分明顯低于對(duì)照組,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。(3)臨床療效比較:治療3個(gè)月后,治療組31例兒童白癜風(fēng)中,治愈6例,顯效11例,好轉(zhuǎn)11例,無(wú)效3例,臨床總有效率90.32%;對(duì)照組32例患兒中,治愈3例,顯效4例,好轉(zhuǎn)17例,無(wú)效8例,臨床總有效率75.00%。經(jīng)統(tǒng)計(jì)學(xué)分析,治療組總有效率90.32%明顯高于對(duì)照組75.00%,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。(4)IL-17水平比較:治療前治療組與對(duì)照組IL-17水平比較,差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05),具有可比性。治療3個(gè)月后兩組自身前后比較IL-17水平均降低(P0.01);組間比較治療組IL-17水平顯著低于對(duì)照組,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。(5)治療組與對(duì)照組在治療過(guò)程中,均未出現(xiàn)明顯不良反應(yīng)。結(jié)論:益肺健脾祛白方聯(lián)合NB-UVB治療兒童白癜風(fēng)臨床療效明顯優(yōu)于單用NB-UVB,可顯著改善皮損面積,其作用機(jī)制可能與降低血清中IL-17含量有關(guān)。
[Abstract]:Objective: to observe the changes of skin lesion area and serum IL-17 in children with vitiligo before and after treatment with Yifei Jianpi Qubai Fang and NB-UVB (narrow spectrum ultraviolet B) in order to verify the clinical effect of combined therapy and to explore the relationship between IL-17 level and vitiligo in children. Methods: according to the principle of random control, 66 children with vitiligo were divided into treatment group (32 cases) and control group (34 cases). The treatment group was given local irradiation of Yifei Jianpi Qubai Fang combined with NB-UVB while the control group was treated with NB-UVB. The treatment group was treated with the same treatment group and the two groups were treated externally with the tincture of dispersing cold and activating blood circulation and removing white. One month was a course of treatment for three courses. To observe and record the score of skin lesion area before and after treatment, and to judge the clinical effect. At the same time, Elisa was used to detect the level of IL-17 in peripheral blood of the two groups before and after treatment, and to compare the level of IL-17 before and after treatment. Results there were 3 cases of shedding in this study, and 63 cases were included (treatment group 31 cases, control group 32 cases). There was no significant difference in sex, age, course of disease, stage and type between the two groups, but there was no significant difference between the two groups (P 0.05). The comparison of VASI scores between the treatment group and the control group before treatment was significant. The differences were not statistically significant (P 0.05) and were comparable. After 3 months of treatment, the VASI scores of the two groups were significantly lower than those of the control group before and after treatment, and the scores of VASI in the treatment group were significantly lower than those in the control group (P 0.05, P 0.05): after 3 months of treatment, there were 31 children with vitiligo in the treatment group. There were 6 cases of cure, 11 cases of remarkable effect, 11 cases of improvement, 3 cases of ineffective, the total effective rate of clinical was 90.32%, in the control group, 3 cases were cured, 4 cases were markedly effective, 17 cases were improved, 8 cases were ineffective, the total clinical effective rate was 75.00%. By statistical analysis, the total effective rate of the treatment group was 90.32% higher than that of the control group (75.00%), and the difference was statistically significant. After 3 months of treatment, the levels of IL-17 in the two groups were significantly lower than those in the control group (P 0.05) and the levels of IL-17 in the treatment group were significantly lower than those in the control group. Conclusion: the clinical effect of Yifei Jianpi Qubai Fang combined with NB-UVB in the treatment of children vitiligo is better than that of NB-UVB alone, and can significantly improve the area of skin lesion. The mechanism may be related to the decrease of IL-17 content in serum.
【學(xué)位授予單位】：廣西中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R758.41

【參考文獻(xiàn)】

相關(guān)期刊論文 前10條

1 陳淑彥;金富坤;;荊芥防風(fēng)在皮膚病治療中的應(yīng)用[J];中國(guó)民間療法;2017年01期

2 李兆榮;劉華平;吳濤;;史鎖芳教授運(yùn)用大劑量黃芪臨床經(jīng)驗(yàn)[J];中國(guó)中醫(yī)急癥;2016年12期

3 鄭榮先;;黃芪的藥理作用及在臨床中的應(yīng)用研究[J];中國(guó)實(shí)用醫(yī)藥;2016年32期

4 楊慶;李玉潔;陳穎;翁小剛;蔡維艷;李琦;王婭杰;王新才;朱曉新;;大棗提取物對(duì)缺鐵性貧血大鼠的保護(hù)作用[J];中國(guó)實(shí)驗(yàn)方劑學(xué)雜志;2017年03期

5 張雪青;邵鄰相;吳文才;邵文麗;趙鐵軍;徐玲玲;;白術(shù)揮發(fā)油抑菌及抗腫瘤作用研究[J];浙江師范大學(xué)學(xué)報(bào)(自然科學(xué)版);2016年04期

6 劉威;王振中;胡軍華;李家春;張振秋;蕭偉;;基于ICP-MS法對(duì)桂枝中24種微量元素的測(cè)定及形態(tài)分析和量變規(guī)律研究[J];藥物分析雜志;2016年10期

7 高石曼;劉久石;孫恬;劉鳳松;景浩;齊耀東;張本剛;劉海濤;肖培根;;不同栽培措施對(duì)黨參藥材化學(xué)質(zhì)量的影響[J];中國(guó)中藥雜志;2016年20期

8 李穎飛;龔雨萍;;《醫(yī)學(xué)衷中參西錄》中桂枝的臨床應(yīng)用[J];上海中醫(yī)藥雜志;2016年10期

9 陳劍平;李中桂;張尚斌;鄭平;董婷霞;詹華強(qiáng);;大棗神經(jīng)保護(hù)作用的活性組分篩選及其作用機(jī)制研究[J];中國(guó)藥房;2016年25期

10 梁璐;;桂枝的藥理作用分析及其臨床應(yīng)用研究[J];中國(guó)醫(yī)藥指南;2016年25期

，

本文編號(hào)：1988074