本文選題：鮑溫病 + 人乳頭瘤病毒感染�。� 參考：《中華醫(yī)院感染學(xué)雜志》2017年20期

【摘要】：目的分析鮑溫病(BD)組織中人乳頭瘤病毒(HPV)感染與微衛(wèi)星(MS)DNA改變的關(guān)系。方法收集2011年1月-2015年10月醫(yī)院收治的30例BD患者的病理組織標(biāo)本,作為觀察組,選取同期外科切除的正常組織標(biāo)本30份作為對(duì)照組,均采用基因芯片技術(shù)檢測(cè)HPV分型,探討B(tài)D組織HPV感染與微衛(wèi)星DNA改變的關(guān)系。結(jié)果觀察組HPV感染陽(yáng)性11例,感染率為36.67%,明顯高于對(duì)照組(P0.05),且觀察組檢出HPV亞型均為高危型,其中HPV16亞型感染所占比例最高,為63.64%;觀察組MS DNA改變檢出率為20.00%,明顯高于對(duì)照組(P0.05),其LOH所占比例高于對(duì)照組(P0.05);BD組織與P53連鎖的D17S796、D17S926位點(diǎn)共發(fā)生LOH 3例,與錯(cuò)配修復(fù)基因hMLH1連鎖的D3S1612、D3S1029位點(diǎn)發(fā)現(xiàn)MSI 1例,LOH 2例;HPV感染11例中,MS DNA改變5例占45.45%,其中HPV16亞型感染中MS DNA改變中MSI占14.29%,LOH占42.36%;HPV58亞型感染中LOH占100.00%;HPV陰性中LOH 1例,占5.26%;HPV陽(yáng)性組MS DNA改變發(fā)生率明顯高于HPV陰性組(P0.05)。結(jié)論 BD發(fā)生與高危型HPV感染及MS DNA改變有一定相關(guān)性,P53基因突變可能參與BD發(fā)病過(guò)程;高危型HPV感染與BD MS DNA改變有一定的關(guān)系。
[Abstract]:Objective to analyze the relationship between the infection of human papillomavirus (HPV) and the DNA changes of MSN in BDB. Methods from January 2011 to October 2015, 30 pathological specimens of BD patients were collected as observation group and 30 normal tissues as control group. HPV typing was detected by gene chip technique. To investigate the relationship between BD tissue HPV infection and microsatellite DNA changes. Results the positive rate of HPV infection in the observation group was 36.67, which was significantly higher than that in the control group (P0.05). The HPV subtypes were found to be high risk type in the observation group, and the HPV16 subtype was the highest in the observation group. The detection rate of MS DNA in the observation group was 20.00, which was significantly higher than that in the control group (P0.05A), and the proportion of LOH in the observation group was higher than that in the control group (P 0.05). There were 3 cases of LOH in the D17S796FN D17S926 locus linked to p53 in the control group. The D3S1612mD3S1029 locus linked to the mismatch repair gene hMLH1 showed that 1 case of MSI had Loh 2 cases of HPV-HPV-infected 11 cases, 5 cases had MS DNA change (45.45%), and in the HPV16 subtype infection, MSI DNA change accounted for 14.29% and MSI accounted for 14.29% of MSI in HPV58 subtype infection. LOH accounted for 1 case of HPV-negative in HPV58 subtype infection, and LOH accounted for 1 case of HPV-negative in HPV58 subtype infection. The incidence of MS DNA changes in 5.26% of the patients with HPV-positive was significantly higher than that in the HPV negative group (P 0.05). Conclusion the mutation of p53 gene may be involved in the pathogenesis of BD with high risk HPV infection and the change of MS DNA, and the high risk HPV infection may be related to the change of BD MS DNA.
【作者單位】： 遵義醫(yī)學(xué)院附屬醫(yī)院皮膚科;
【分類(lèi)號(hào)】：R739.5

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