本文選題：阿達帕林 + 醫(yī)用愈膚生物膜��； 參考：《中國皮膚性病學雜志》2014年04期

【摘要】：目的評價0.1%阿達帕林凝膠聯(lián)合醫(yī)用愈膚生物膜治療痤瘡炎性丘疹的療效和安全性。方法采用開放的隨機對照研究。按照通用標準選擇炎性痤瘡患者共95例,其中治療組50例,對照組45例。治療組早晨、傍晚各外敷一次醫(yī)用愈膚生物膜,每次15min,夜間睡眠前外涂0.1%阿達帕林凝膠;對照組夜間睡眠前外涂0.1%阿達帕林凝膠。分別于初診時、2周、4周、8周觀察炎性丘疹的數(shù)量、不良反應(干燥、紅斑、脫屑、灼熱等)的情況。結果在治療第4周時,治療組有效率為66.00%,對照組為44.44%,差異有統(tǒng)計學意義(P=0.035);治療8周時,治療組有效率為94.00%,對照組為77.78%,差異有統(tǒng)計學意義(P=0.022);治療組不良反應發(fā)生率為6.00%,對照組為22.22%,差異有統(tǒng)計學意義(P=0.008)。結論阿達帕林凝膠聯(lián)合醫(yī)用愈膚生物膜治療痤瘡炎性丘疹療效顯著,不良反應少。
[Abstract]:Objective to evaluate the efficacy and safety of 0.1% adaline gel combined with medical skin healing biofilm in the treatment of acne inflammatory papules. Methods an open randomized controlled study was used. A total of 95 patients with inflammatory acne were selected according to the general criteria, including 50 cases in the treatment group and 45 cases in the control group. In the morning and evening, the treatment group was treated with 0.1% adalin-gel before nighttime sleep, and the control group was treated with 0.1% adalin-gel before nighttime sleep. The quantity of inflammatory papules, adverse reactions (dry, erythema, detritus, scorching, etc.) were observed at 2 weeks and 4 weeks and 8 weeks respectively during the first visit. Results at the 4th week of treatment, the effective rate was 66.00 in the treatment group and 44.44 in the control group. The effective rate was 94.00 in the treatment group and 77.78 in the control group, the difference being statistically significant, the incidence of adverse reactions in the treatment group was 6.00, and that in the control group was 22.222.The difference was statistically significant. Conclusion Adapaline gel combined with medical Yufu biofilm is effective in the treatment of acne inflammatory papules with less adverse reactions.
【作者單位】： 江西省人民醫(yī)院皮膚科;
【分類號】：R758.733

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本文編號：1892298