本文選題：瘦素 + 瘦素受體　； 參考：《中國(guó)醫(yī)科大學(xué)》2010年碩士論文

【摘要】： 目的 銀屑病是一種常見的慢性炎癥性皮膚病,其確切病因尚未完全清楚。新近研究表明,銀屑病和代謝綜合征有關(guān)：伴有代謝綜合征的銀屑病患者較不患代謝綜合征的患者年齡更大,病程更長(zhǎng)。代謝綜合征是以胰島素抵抗為核心,遺傳異質(zhì)性和環(huán)境因素導(dǎo)致的一系列心血管疾病高危因素的聚集狀態(tài)。肥胖是其發(fā)生的源頭。脂肪組織可以分泌多種生物活性物質(zhì),這些物質(zhì)被稱為脂肪因子。瘦素(leptin)和脂聯(lián)素(adiponectin)是近年來發(fā)現(xiàn)的特異性脂肪因子,是體內(nèi)營(yíng)養(yǎng)狀態(tài)與神經(jīng)內(nèi)分泌-免疫系統(tǒng)之間相互影響、相互作用的重要中介。瘦素主要通過與存在于多種組織中的多種形式的受體(OB-R)結(jié)合,調(diào)節(jié)T細(xì)胞的功能及其細(xì)胞因子的產(chǎn)生,影響自身免疫性疾病的發(fā)生與發(fā)展。脂聯(lián)素是脂肪組織表達(dá)最豐富的激素,不僅與肥胖及胰島素抵抗有著密切的關(guān)系,而且具有重要的抗炎及血管保護(hù)作用。已有研究表明瘦素與多種皮膚疾病相關(guān),如白塞綜合征、系統(tǒng)性紅斑狼瘡、硬皮病、天皰瘡等。為了探討這兩種脂肪因子與尋常型銀屑病的相關(guān)性,我們測(cè)定了尋常型銀屑病患者血清瘦素、可溶性瘦素受體和脂聯(lián)素的水平,分析其在尋常型銀屑病中的變化及意義。 方法 采用夾心法酶聯(lián)免疫吸附技術(shù)檢測(cè)48例尋常型銀屑病(PV)患者及30例正常對(duì)照組血清瘦素、可溶性瘦素受體及脂聯(lián)素的水平。計(jì)量資料以均數(shù)±標(biāo)準(zhǔn)差(x±s)表示,應(yīng)用SPSS13.0軟件系統(tǒng)進(jìn)行t檢驗(yàn)及Pearson相關(guān)分析,p0.05有統(tǒng)計(jì)學(xué)意義。 結(jié)果 與正常對(duì)照組相比,PV患者血清可溶性瘦素受體及脂聯(lián)素水平明顯降低,差異有統(tǒng)計(jì)學(xué)意義(p0.01)；血清瘦素水平可見顯著的性別差異,女性較男性瘦素水平明顯升高,差異有統(tǒng)計(jì)學(xué)意義(p0.01)；男性患者較男性正常對(duì)照脂聯(lián)素水平明顯降低,差異有統(tǒng)計(jì)學(xué)意義(p0.01)；女性患者較女性正常對(duì)照可溶性瘦素受體水平明顯降低,差異有統(tǒng)計(jì)學(xué)意義(p0.05)；BMI(體質(zhì)指數(shù))25的患者較正常對(duì)照可溶性瘦素受體及脂聯(lián)素水平明顯降低,差異有統(tǒng)計(jì)學(xué)意義(p0.01)。患者病情.嚴(yán)重程度(PASI)與BMI及瘦素／脂聯(lián)素的比值呈正相關(guān)(p0.01,r=0.44；p0.01,r=0.40)。 結(jié)論 尋常型銀屑病中存在瘦素、瘦素受體和脂聯(lián)素水平的異常,瘦素及脂聯(lián)素水平的變化可能在銀屑病發(fā)生、發(fā)展過程中起作用。
[Abstract]:Purpose Psoriasis is a common chronic inflammatory dermatosis whose exact etiology is not fully understood. Recent studies have shown that psoriasis is associated with metabolic syndrome: psoriatic patients with metabolic syndrome are older and longer in duration than those without metabolic syndrome. Metabolic syndrome is the aggregation of a series of high risk factors of cardiovascular disease caused by genetic heterogeneity and environmental factors with insulin resistance as the core. Obesity is the source of its occurrence. Adipose tissue can secrete a variety of bioactive substances, known as fat factors. Leptin (leptinin) and adiponectin (adiponectin) are specific fat factors found in recent years. They are important mediators of the interaction between nutritional status and neuroendocrine immune system in vivo. Leptin regulates the function of T cells and the production of cytokines by binding to various forms of receptor OB-Rin in various tissues and affects the occurrence and development of autoimmune diseases. Adiponectin is the most abundant hormone in adipose tissue. Adiponectin is not only closely related to obesity and insulin resistance, but also has important anti-inflammatory and vascular protective effects. Leptin has been linked to many skin diseases, such as Behcet's syndrome, systemic lupus erythematosus, scleroderma, pemphigus, etc. In order to investigate the relationship between these two kinds of fat factors and psoriasis vulgaris, we measured the serum leptin, soluble leptin receptor and adiponectin levels in patients with psoriasis vulgaris, and analyzed their changes and significance in psoriasis vulgaris. Method The levels of serum leptin, soluble leptin receptor and adiponectin in 48 patients with psoriasis vulgaris PVV and 30 normal controls were detected by enzyme-linked immunosorbent assay (Elisa). The measurement data were expressed as mean 鹵standard deviation (x 鹵s). The SPSS13.0 software system was used for t test and Pearson correlation analysis (p0.05). Result The serum levels of soluble leptin receptor and adiponectin in PV patients were significantly lower than those in normal controls (P 0.01), and the serum leptin levels in women were significantly higher than those in men. The level of adiponectin in male patients was significantly lower than that in normal controls (P 0.01), and the level of soluble leptin receptor in female patients was significantly lower than that in normal controls. The levels of soluble leptin receptor and adiponectin in patients with BMI 25 were significantly lower than those in normal controls (P 0.01). The patient's condition. The severity of PASI was positively correlated with BMI and the ratio of leptin to adiponectin. Conclusion There are abnormal levels of leptin, leptin receptor and adiponectin in psoriasis vulgaris. The changes of leptin and adiponectin levels may play an important role in the pathogenesis and development of psoriasis.
【學(xué)位授予單位】：中國(guó)醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2010
【分類號(hào)】：R758.63

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本文編號(hào)：1860144