發(fā)布時(shí)間：2018-05-05 14:43

  本文選題：銀屑病 + Notch家族蛋白　； 參考：《臨床皮膚科雜志》2015年03期

【摘要】：目的:探討Notch家族蛋白在銀屑病發(fā)病機(jī)制中的作用。方法:收集58例銀屑病患者皮損組織病理標(biāo)本為患者組,同期收集28例表皮痣組織病理標(biāo)本為對(duì)照組,采用免疫組化法檢測(cè)Notch信號(hào)受體、配體(Notch1-4、DLL1、3、4和Jagged1、2)在患者組和對(duì)照組皮損標(biāo)本中的定位及表達(dá)。結(jié)果:1Notch1、2、3、4,Jagged1、2,DLL1、3、4在銀屑病患者皮損表皮中的表達(dá)水平較對(duì)照組皮損表皮中增強(qiáng),兩組之間差異有統(tǒng)計(jì)學(xué)意義(P0.05);2Notch1、2、3、4,Jagged1,DLL1、3在銀屑病患者皮損真皮中的表達(dá)水平較對(duì)照組皮損真皮中增強(qiáng),兩組之間差異有統(tǒng)計(jì)學(xué)意義(P0.05);3DLL4和Jagged2在銀屑病患者皮損真皮中的表達(dá)水平與對(duì)照組相比,差異無統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論:Notch1-4,Jagged1、2,DLL1、3、4在銀屑病患者皮損中表達(dá)增強(qiáng),可能參與了銀屑病的發(fā)病機(jī)制。
[Abstract]:Objective: to investigate the role of Notch family proteins in the pathogenesis of psoriasis. Methods: 58 patients with psoriasis and 28 patients with epidermal nevus were collected as control group. Immunohistochemical method was used to detect Notch signal receptor. The localization and expression of the ligand Notch1-4 DL1O3O4 and Jagged1m2in the skin lesions of patients and controls. Results the expression level of 1 / 1Notch1C / 2Notch1C / DLL1O3O4 in psoriasis patients was significantly higher than that in the control group (P 0.05). There was a significant difference between the two groups in the expression of DLL13 in the dermis of psoriatic patients with psoriasis, and the expression level of DLL13 in the dermis of psoriatic patients was significantly higher than that in the control group (P < 0.05), and the expression level of DLL1 / 3 in the dermis of psoriatic patients was significantly higher than that in the control group (P < 0.05), and there was no significant difference between the two groups in the expression of DLL13 in psoriatic lesions. There was significant difference between the two groups in the expression of P0.05DLL4 and Jagged2 in the dermis of psoriasis patients, and there was no significant difference between the two groups compared with the control group (P 0.05). Conclusion the expression of 1 / Notch1-4 / Jagged1 / 2 DLL1 / 3 / 4 is increased in psoriatic lesions, which may be involved in the pathogenesis of psoriasis.
【作者單位】： 北京市昌平區(qū)中西醫(yī)結(jié)合醫(yī)院皮膚病與性病科;中日友好醫(yī)院皮膚病與性病科;
【基金】：國家自然科學(xué)基金(81173270)資助項(xiàng)目
【分類號(hào)】：R758.63

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