發(fā)布時間：2018-05-04 07:17

  本文選題：黑素瘤 + 手術(shù)��； 參考：《中國皮膚性病學(xué)雜志》2017年06期

【摘要】：目的探討手術(shù)聯(lián)合小劑量干擾素治療早期皮膚黑素瘤的臨床療效和安全性。方法回顧本科2007年4月-2011年3月收治的早期皮膚黑素瘤患者的臨床資料。結(jié)果 31例患者中,男17例,女14例;年齡42~77歲,病程3個月~6年,術(shù)前均未見局部淋巴結(jié)轉(zhuǎn)移或遠處轉(zhuǎn)移灶,臨床上屬Ⅰa~Ⅱc期,予皮損擴大切除(或截肢)加植皮或皮瓣修復(fù)術(shù)聯(lián)合小劑量干擾素(300萬U,3次/周)治療18個月后,21例切口愈合良好,隨訪5年無復(fù)發(fā),腫瘤厚(2.11±0.86)mm。10例于術(shù)后4~25個月時復(fù)發(fā),其中1例Ⅱa期,6例Ⅱb期,3例Ⅱc期,腫瘤厚(3.62±1.16)mm。4例因黑素瘤轉(zhuǎn)移死亡,其中1例Ⅱb期,3例Ⅱc期。27例存活患者中有1例白細胞下降顯著而停止干擾素注射�？偵媛�87.10%,無病生存期44.1個月,5年無復(fù)發(fā)生存率67.74%。結(jié)論手術(shù)切除聯(lián)合干擾素治療早期皮膚黑素瘤預(yù)后尚可,與術(shù)后聯(lián)合大劑量干擾素相比,療效相似,且不良反應(yīng)相對較輕,患者的依從性高,但是療效可能受腫瘤的病理類型、厚度和分期影響。
[Abstract]:Objective to evaluate the efficacy and safety of low-dose interferon in the treatment of early cutaneous melanoma. Methods the clinical data of patients with early cutaneous melanoma from April 2007 to March 2011 were reviewed. Results among the 31 patients, 17 were male and 14 were female, aged 42 to 77 years, the course of disease was from 3 months to 6 years. No local lymph node metastasis or distant metastasis was found before operation. After 18 months of extensive excision (or amputation) and skin graft or flap repair combined with low dose interferon (3 million UU 3 times / week), 21 cases of incision healed well, and no recurrence occurred in the follow-up of 5 years. Tumor thickness of 2.11 鹵0.86)mm.10 recurred at 4 ~ 25 months after operation. One patient with stage 鈪，

本文編號：1842101