本文選題：斑片試驗(yàn) + 復(fù)方甘草酸苷��； 參考：《蘇州大學(xué)》2016年碩士論文

【摘要】：目的探究復(fù)方甘草酸苷制劑對皮膚斑貼試驗(yàn)的影響。方法第一次斑貼試驗(yàn)后分別給予復(fù)方甘草酸苷制劑中劑量干預(yù)(復(fù)方甘草酸苷片50mg tid口服)、2周后重復(fù)第二次皮膚斑貼試驗(yàn);高劑量干預(yù)(復(fù)方甘草酸苷片75mg tid口服),2周后重復(fù)第二次皮膚斑貼試驗(yàn);靜脈途徑干預(yù)(復(fù)方甘草酸苷注射液,60ml/日),1周后重復(fù)第二次皮膚斑貼試驗(yàn)。應(yīng)用SPSS 19.0版軟件進(jìn)行秩和檢驗(yàn),從斑貼試驗(yàn)是否有性質(zhì)改變的定性角度和改變的反應(yīng)程度兩個(gè)角度分別編秩進(jìn)行統(tǒng)計(jì)學(xué)分析。結(jié)果中劑量干預(yù):完成研究81例患者,第2次斑貼試驗(yàn)時(shí):66例“++”,13例“+”,2例“+++”,無陰性結(jié)果者。兩次斑貼試驗(yàn)結(jié)果:定性角度無變化;反應(yīng)程度角度,Z=-2.84,P=0.005,差異有統(tǒng)計(jì)學(xué)意義。高劑量干預(yù):完成研究82例患者,第2次斑貼試驗(yàn)時(shí):37例“++”,36例“+”,9例“-”陰性。兩次斑貼試驗(yàn)結(jié)果:定性角度:Z=-3.000,P=0.003;反應(yīng)程度角度,Z=-6.247,P=0.000,差異均有顯著統(tǒng)計(jì)學(xué)意義。靜脈途徑干預(yù):完成研究58例患者,第2次斑貼試驗(yàn)時(shí):12例“++”,10例“+”,36例“-”陰性。兩次斑貼試驗(yàn)結(jié)果:定性角度:Z=-6.000,P=0.000;反應(yīng)程度角度,Z=-6.289,P=0.000,差異均有顯著統(tǒng)計(jì)學(xué)意義。結(jié)論復(fù)方甘草酸苷制劑口服高劑量和靜脈途徑應(yīng)用時(shí)對皮膚斑貼試驗(yàn)反應(yīng)有明顯抑制作用。建議做斑貼試驗(yàn)前應(yīng)停此藥2周。
[Abstract]:Objective to investigate the effect of compound glycyrrhizin on skin patch test. Methods after the first patch test, the medium dose of compound glycyrrhizin preparation was given respectively. The second skin patch test was repeated after 50mg tid was given orally for 2 weeks. High dose intervention (the second skin patch test was repeated 2 weeks after the oral administration of 75mg tid and the second skin patch test was repeated after 1 week after the injection of compound glycyrrhizin injection 60 ml / day). The rank sum test was carried out with SPSS version 19.0 software, and the rank was compiled from the qualitative angle of property change and the degree of reaction of the change from the qualitative angle and the degree of reaction of the patch test. Results Medium-dose intervention: 81 patients completed the study, the second patch test in 66 cases of "13 cases" and "2 cases", no negative results. The results of two patch tests showed that there was no change in qualitative angle, and the degree of reaction was 0. 005. The difference was statistically significant. High dose intervention: 82 patients were studied. In the second patch test, 37 cases (36 cases), 9 cases (9 cases) were negative. The results of two patch tests were as follows: qualitative angle: 1: Z ~ (-3.000) P ~ (0.003), and reaction angle = Z ~ (-6.247) P ~ (0. 000). The difference was statistically significant. Intravenous approach intervention: 58 patients completed the study, the second patch test in 12 cases, "10 cases", "36 cases"-"negative". The results of two patch tests were as follows: qualitative angle was 0.000 and reaction degree was 0.000, the difference was statistically significant. Conclusion compound glycyrrhizin has obvious inhibitory effect on skin patch test when high dose oral and intravenous administration. It is suggested that the drug should be stopped for 2 weeks before patch test.
【學(xué)位授予單位】：蘇州大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2016
【分類號】：R751.05

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