本文選題：節(jié)段型 + 泛發(fā)型��； 參考：《中國(guó)老年學(xué)雜志》2017年23期

【摘要】：目的探討黑素細(xì)胞自噬和老年白癜風(fēng)患者臨床類(lèi)型的關(guān)系。方法選取88例老年白癜風(fēng)患者,包括41例節(jié)段型白癜風(fēng)患者(節(jié)段型組)和47例泛發(fā)型白癜風(fēng)患者(泛發(fā)型組),同時(shí)選取健康體檢的健康老年志愿者88例為對(duì)照組。比較節(jié)段型組和泛發(fā)型組患者的臨床特征,比較節(jié)段型組和泛發(fā)型組白斑區(qū)周?chē)Ｄw色部位皮膚和對(duì)照組任意部位正常膚色皮膚的黑素細(xì)胞誘導(dǎo)前后自噬體數(shù)量和微管相關(guān)蛋白1輕鏈3(LC3)Ⅱ、小眼球畸形相關(guān)轉(zhuǎn)錄因子(MITF)、酪氨酸酶相關(guān)蛋白(TRPs)相對(duì)表達(dá)情況。結(jié)果節(jié)段型組和泛發(fā)型組發(fā)病年齡、家族史、伴有暈痣和復(fù)發(fā)率差異無(wú)統(tǒng)計(jì)學(xué)意義(均P0.05);節(jié)段型組同形反應(yīng)少于泛發(fā)型組(P0.05)。誘導(dǎo)前節(jié)段型組和對(duì)照組可見(jiàn)自噬點(diǎn)數(shù)目顯著多于泛發(fā)型組(P0.05);誘導(dǎo)后3組自噬點(diǎn)數(shù)目較誘導(dǎo)前均顯著增多,且泛發(fā)型組顯著多于節(jié)段型組和對(duì)照組,對(duì)照組顯著多于節(jié)段型組(P0.05)。誘導(dǎo)前泛發(fā)型組MITF顯著高于節(jié)段型組和泛發(fā)型組,LC3Ⅱ、TYR、TYRP1和TYRP2均顯著低于節(jié)段型組和泛發(fā)型組;誘導(dǎo)后3組MITF、LC3Ⅱ、TYR、TYRP1較誘導(dǎo)前均顯著升高,且泛發(fā)型組MITF、TYR、TYRP1高于節(jié)段型組和泛發(fā)型組(P0.05)。結(jié)論白癜風(fēng)患者黑素細(xì)胞存在自噬現(xiàn)象,對(duì)功能性分子表達(dá)產(chǎn)生影響,且泛發(fā)型白癜風(fēng)黑素細(xì)胞自噬現(xiàn)象和對(duì)功能性分子表達(dá)的影響較大。
[Abstract]:Objective to investigate the relationship between melanocyte autophagy and clinical types in elderly patients with vitiligo.Methods 88 elderly patients with vitiligo, including 41 patients with segmental vitiligo (segmental group) and 47 patients with generalized vitiligo (generalized vitiligo) were selected. 88 healthy elderly volunteers were selected as control group.To compare the clinical characteristics between segmental type group and general type group,To compare the number of macrophages and microtubule-associated protein 1 light chain 3C3 (鈪，

本文編號(hào)：1764579