本文選題：節(jié)段型 + 泛發(fā)型��； 參考：《中國老年學雜志》2017年23期

【摘要】：目的探討黑素細胞自噬和老年白癜風患者臨床類型的關系。方法選取88例老年白癜風患者,包括41例節(jié)段型白癜風患者(節(jié)段型組)和47例泛發(fā)型白癜風患者(泛發(fā)型組),同時選取健康體檢的健康老年志愿者88例為對照組。比較節(jié)段型組和泛發(fā)型組患者的臨床特征,比較節(jié)段型組和泛發(fā)型組白斑區(qū)周圍正常膚色部位皮膚和對照組任意部位正常膚色皮膚的黑素細胞誘導前后自噬體數(shù)量和微管相關蛋白1輕鏈3(LC3)Ⅱ、小眼球畸形相關轉錄因子(MITF)、酪氨酸酶相關蛋白(TRPs)相對表達情況。結果節(jié)段型組和泛發(fā)型組發(fā)病年齡、家族史、伴有暈痣和復發(fā)率差異無統(tǒng)計學意義(均P0.05);節(jié)段型組同形反應少于泛發(fā)型組(P0.05)。誘導前節(jié)段型組和對照組可見自噬點數(shù)目顯著多于泛發(fā)型組(P0.05);誘導后3組自噬點數(shù)目較誘導前均顯著增多,且泛發(fā)型組顯著多于節(jié)段型組和對照組,對照組顯著多于節(jié)段型組(P0.05)。誘導前泛發(fā)型組MITF顯著高于節(jié)段型組和泛發(fā)型組,LC3Ⅱ、TYR、TYRP1和TYRP2均顯著低于節(jié)段型組和泛發(fā)型組;誘導后3組MITF、LC3Ⅱ、TYR、TYRP1較誘導前均顯著升高,且泛發(fā)型組MITF、TYR、TYRP1高于節(jié)段型組和泛發(fā)型組(P0.05)。結論白癜風患者黑素細胞存在自噬現(xiàn)象,對功能性分子表達產(chǎn)生影響,且泛發(fā)型白癜風黑素細胞自噬現(xiàn)象和對功能性分子表達的影響較大。
[Abstract]:Objective to investigate the relationship between melanocyte autophagy and clinical types in elderly patients with vitiligo.Methods 88 elderly patients with vitiligo, including 41 patients with segmental vitiligo (segmental group) and 47 patients with generalized vitiligo (generalized vitiligo) were selected. 88 healthy elderly volunteers were selected as control group.To compare the clinical characteristics between segmental type group and general type group,To compare the number of macrophages and microtubule-associated protein 1 light chain 3C3 (鈪，

本文編號：1764579