本文選題：降鈣素原　切入點：膿皰瘡　出處：《暨南大學(xué)》2011年碩士論文

【摘要】：目的：探討降鈣素原(PCT)在新生兒膿皰瘡合并敗血癥中的臨床應(yīng)用價值 方法：收集我院2006年1月至2010年12月新生兒科收住的137例新生兒膿皰瘡,其中男86例,女51例；足月兒125例,早產(chǎn)兒12例；同期我院新生兒科住院非感染新生兒118例,其中男79例,女39例；足月兒109例,早產(chǎn)兒9例。根據(jù)研究目的將上述病例分為三組,新生兒膿皰瘡組合并敗血癥組(A組)9例,按照1987年全國新生兒會議制定的《新生兒敗血癥診斷標準修訂方案》診斷,新生兒膿皰瘡組128例(B組)和非感染組(C組)118例。各實驗對象均嚴格無菌采血,立即用200μl血清用半定量固相免疫層析法檢測PCT(德國B.R.A.H.M.S Aktiengesellschaft產(chǎn)品)。其中膿皰瘡兩組(A組,B組)做血培養(yǎng)(美國BD公司兒童血培養(yǎng)瓶)置BACTEC 9050血培養(yǎng)儀內(nèi)觀察結(jié)果。兩組間計量分析資料采用兩樣本t檢驗進行統(tǒng)計分析：計數(shù)資料采用χ2檢驗進行統(tǒng)計分析。 結(jié)果：當PCT0.5ng/ml時,新生兒膿皰瘡合并新生兒敗血癥組(A組)與非感染組(C組)相比有顯著的統(tǒng)計學(xué)意義(P0.01)；當PCT0.5ng/ml時,新生兒膿皰瘡組(B組)與非感染組(C組)相比有顯著的統(tǒng)計學(xué)意義(P0.01)；當PCT2ng/ml時新生兒膿皰瘡合并新生兒敗血癥組(A組)與新生兒膿皰瘡組(B組)相比有顯著的統(tǒng)計學(xué)意義(P0.01)；當PCT2ng/ml時,新生兒膿皰瘡組(B組)與非感染組(C組)相比無顯著的統(tǒng)計學(xué)意義(P0.05)；當PCT2ng/ml時,PCT-Q法與血培養(yǎng)結(jié)果比較有顯著性差異(P0.01)。 結(jié)論：細菌感染時血清PCT早期即升高,當PCT0.5ng/ml時,臨床提示存在細菌感染,當PCT2ng/ml時,可作為新生兒膿皰瘡合并敗血癥早期診斷有價值的指標
[Abstract]:Objective: to evaluate the clinical value of procalcitonin (PCT) in neonatal pustular ulcers complicated with septicemia. Methods: from January 2006 to December 2010, 137 neonates with pustular ulcers were collected, including 86 males and 51 females, 125 full-term infants and 12 premature infants. There were 79 males and 39 females, 109 term infants and 9 premature infants. According to the objective of the study, the patients were divided into three groups: group A with neonatal pustular ulcers combined with septicemia (n = 9), and group A (n = 9) with neonatal pustular ulcers combined with septicemia. According to the revised Diagnostic Standard for Neonatal septicemia formulated by the National Conference of Neonates in 1987, 128 cases of neonatal pustular ulcers group (group B) and 118 cases of group C (non-infection group) were diagnosed. The results of blood culture were detected by semi-quantitative solid-phase immunochromatography (semi-quantitative solid-phase immunochromatography) with 200 渭 l serum (German B.R.A.H.M.S Aktiengesellschaft product). The blood culture was performed in group A and B of pustular ulcers. The results were observed by placing BACTEC 9050 blood culture bottle in the blood culture flask of BD company in the United States of America. Two samples t test were used for statistical analysis and 蠂 2 test was used for statistical analysis of counting data. Results: when PCT0.5ng/ml, neonatal pustular ulcers with neonatal septicemia group (group A) was significantly higher than that of non-infection group (group C) (P 0.01), and when PCT0.5ng/ml, there was no significant difference between group A and group C (P < 0.05). Neonatal pustular ulcers group (group B) and non-infection group (group C) (P 0.01); when PCT2ng/ml neonatal pustular ulcers with neonatal septicemia group (group A) compared with neonatal pustular ulcer group (group B) there are significant statistics. When PCT2ng/ml, There was no significant difference between group B and group C in neonatal pustular ulcers (P 0.05), and there was a significant difference between the results of blood culture and that of PCT-Q in PCT2ng/ml. Conclusion: the level of serum PCT increases at the early stage of bacterial infection, and when PCT0.5ng/ml, the clinical results indicate that there is bacterial infection. When PCT2ng/ml, it can be used as a valuable index for the early diagnosis of neonatal pustular ulcers complicated with septicemia.
【學(xué)位授予單位】：暨南大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2011
【分類號】：R753.1;R722.1

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本文編號：1692143