本文選題：尋常型銀屑病　切入點：療效分析　出處：《鄭州大學》2014年碩士論文

【摘要】：目的 通過對鄭州大學第二附屬醫(yī)院皮膚科2013年1月至2014年2月間就診的163例尋常型銀屑病患者病例資料進行臨床分析，結(jié)合本地區(qū)銀屑病患者的發(fā)病特點，重點分析抗生素聯(lián)合阿維A膠囊治療尋常型銀屑病的臨床療效和不良反應。 方法 將收集到的163例尋常性銀屑病患者，隨機分為治療組和對照組，其中治療組82例，對照組81例。兩組患者均口服阿維A膠囊，治療8周為一個療程；治療組再加用抗生素治療，抗生素給予的是注射用頭孢硫脒，治療2周為一個療程；治療8周后觀察兩組之間的臨床療效和不良反應；同時將治療組的82例患者再分為點滴狀銀屑病組和斑塊狀銀屑病組，比較兩組使用抗生素聯(lián)合阿維A膠囊治療效果。皮損治療后的消退情況，使用PASI評分方法；兩組之間的對比均采用SPSS17.0軟件，運用秩和檢驗和χ2檢驗的分析方法。 結(jié)果 選擇的163例患者，男性99例，女性64例，男女比例為1.55:1，平均年齡在42.37±17.23歲。兩組在藥物治療前，治療組的PASI評分為8.86±2.02，對照組的PASI評分為8.75±2.04，兩組之間的PASI評分無統(tǒng)計學差異。經(jīng)過4周的藥物治療后，治療組的PASI評分為5.73±0.52，對照組的PASI評分為6.97±1.52；經(jīng)過8周的藥物治療后，治療組的PASI評分為3.66±0.51，對照組的PASI評分為4.53±1.44，兩組治療前后的PASI評分差異均有統(tǒng)計學意義；藥物治療8周后，治療組82例尋常性銀屑病患者中，有效63例，無效19例，有效率為76.83%；對照組81例尋常性銀屑病患者中，有效46例，無效35例，有效率為56.79%。治療組和對照組的有效率比較，P=0.007，χ2=7.39，差異有統(tǒng)計學意義。治療組在治療過程中出現(xiàn)不良反應33例，不良反應發(fā)生率為40.24%，對照組在治療過程中出現(xiàn)不良反應37例，不良反應發(fā)生率為45.68%，比較兩組之間不良反應發(fā)生率差異無統(tǒng)計學意義。將治療組的82例患者分為點滴狀銀屑病組和斑塊狀銀屑病組，其中點滴狀銀屑病47例，斑塊狀銀屑病35例，點滴狀銀屑病組有效42例，無效5例，有效率為89.36%；斑塊狀狀銀屑病組有效22例，無效13例，有效率為62.86%，，點滴狀銀屑病組和斑塊狀銀屑病組的有效率比較，P=0.004，χ2=8.23，差異有統(tǒng)計學意義。點滴狀銀屑病組治療過程中出現(xiàn)不良反應16例，不良反應發(fā)生率為38.10%，斑塊狀銀屑病組治療過程中出現(xiàn)不良反應17例，不良反應發(fā)生率為42.50%，兩組之間不良反應發(fā)生率差異無統(tǒng)計學意義。 結(jié)論 1.抗生素聯(lián)合阿維A膠囊治療尋常型銀屑病比單用阿維A膠囊更有效。 2.抗生素聯(lián)合阿維A膠囊治療點滴狀銀屑病比治療斑塊狀銀屑病療效更好。
[Abstract]:PurposeThe clinical data of 163 cases of psoriasis vulgaris from January 2013 to February 2014 in the Department of Dermatology, second affiliated Hospital of Zhengzhou University were analyzed.The clinical efficacy and adverse reactions of antibiotics combined with avea capsule in the treatment of psoriasis vulgaris were analyzed.Method163 patients with psoriasis vulgaris were randomly divided into treatment group (n = 82) and control group (n = 81).The patients in both groups were treated with Avera capsule for 8 weeks as a course of treatment, and the treatment group was treated with antibiotics, which were given cefathiramidine for injection and a course of treatment for 2 weeks.After 8 weeks of treatment, the clinical efficacy and adverse reactions between the two groups were observed, and 82 patients in the treatment group were divided into two groups: dripping psoriasis group and plaque psoriasis group.PASI score was used to evaluate the regression of skin lesions after treatment, and the comparison between the two groups was performed with SPSS17.0 software, rank sum test and 蠂 2 test.ResultOf 163 patients, 99 were male and 64 were female. The ratio of male to female was 1.55: 1 with an average age of 42.37 鹵17.23 years.Before the treatment, the PASI score of the two groups was 8.86 鹵2.02and the PASI score of the control group was 8.75 鹵2.04.There was no significant difference in the PASI score between the two groups.After 4 weeks of drug therapy, the PASI score of the treatment group was 5.73 鹵0.52, and the PASI score of the control group was 6.97 鹵1.52.After 8 weeks of drug therapy, the PASI score of the treatment group was 5.73 鹵0.52.The PASI score of the treatment group was 3.66 鹵0.51, and the PASI score of the control group was 4.53 鹵1.44.The difference of PASI score between the two groups before and after treatment was statistically significant, and after 8 weeks of drug therapy, there were 63 effective cases and 19 ineffective cases in the treatment group in 82 patients with psoriasis vulgaris.The effective rate was 76.83 and the effective rate was 56.79 in the control group of 81 patients with psoriasis vulgaris.The effective rates of the treatment group and the control group were significantly higher than that of the control group (P 0.007, 蠂 2 = 7.39).There were 33 cases of adverse reactions in the treatment group and 37 cases in the control group. The incidence of adverse reactions was 40.24 in the treatment group and 45.68 in the control group. There was no significant difference in the incidence of adverse reactions between the two groups.Eighty-two patients in the treatment group were divided into two groups: droplet psoriasis group (n = 47), plaque psoriasis group (n = 35), droplet psoriasis group (n = 42) and plaque psoriasis group (n = 5).The effective rate was 89.36 and the effective rate was 62.86 in the plaque psoriasis group (n = 22) and in the plaque psoriasis group (n = 13). The effective rate was significantly higher in the droplet psoriasis group and the plaque psoriasis group than in the plaque psoriasis group (P 0.004, 蠂 2 = 8.23).There were 16 cases of adverse reactions in the treatment of psoriasis and 17 cases in the group of plaque psoriasis, and the incidence of adverse reactions was 38.10% in the group of droplet psoriasis and 17 cases in the group of plaque psoriasis.The incidence of adverse reactions was 42.50, and there was no significant difference between the two groups.Conclusion1.Antibiotics combined with Avera capsule were more effective in the treatment of psoriasis vulgaris than Avera capsule alone.2.Antibiotics combined with Avera capsule were more effective in the treatment of plaque psoriasis than in the treatment of plaque psoriasis.
【學位授予單位】：鄭州大學
【學位級別】：碩士
【學位授予年份】：2014
【分類號】：R758.63

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