本文選題：銀屑病　切入點：光學　出處：《重慶醫(yī)學》2017年03期

【摘要】：目的評價不同起始劑量308nm準分子光治療斑塊狀銀屑病的療效及安全性。方法將94例銀屑病患者按隨機數(shù)字法分為小劑量組、中等劑量組和大劑量組,分別以1、3、6倍最小紅斑量起始劑量308nm準分子光照射,每周最多2次,療程8周。結(jié)果治療后2、4、6、8周小劑量組與中等劑量之間及治療后4、6、8周中等劑量組與大劑量組之間銀屑病皮損面積和嚴重程度指數(shù)(PASI)評分及皮膚生活質(zhì)量指數(shù)(DLQI)評分比較差異均有統(tǒng)計學意義(P0.05)。3組DLQI評分與PASI評分呈顯著正相關(guān)(r=0.826、0.835、0.861,P0.01),DLQI評分改善率與PASI評分改善率亦呈顯著正相關(guān)(r=0.845、0.851、0.896,P0.01)。大劑量組與其余兩組總有效率比較差異有統(tǒng)計學意義(χ~2=12.23、7.36,P0.05);中等劑量組同小劑量總有效率比較差異有統(tǒng)計學意義(χ~2=9.14,P0.05)。大劑量組較中等劑量組及小劑量組照射次數(shù)及總劑量少,治療后滿意度評分高(P0.05);中等劑量組較小劑量組照射次數(shù)及總劑量少,治療后滿意度評分高(P0.05)。大劑量及中等劑量組與小劑量組復發(fā)率比較差異有統(tǒng)計學意義(χ~2=10.58、7.64,P0.05)。結(jié)論大劑量308nm準分子光治療比小劑量療效好,對于總面積小且頑固的皮損,可選擇大劑量照射。
[Abstract]:Objective to evaluate the efficacy and safety of different initial doses of 308nm excimer light in the treatment of plaque psoriasis. The initial dose of 308nm excimer with a minimum erythema dose of 6 times 1 ~ 3 ~ 3 times was irradiated twice a week, respectively. Results the PASI and DLQI scores of psoriasis lesions were measured between the low-dose group and the medium-dose group and between the moderate dose group and the high-dose group at the 8th week after treatment and between the moderate dose group and the high dose group. The PASI score and the skin quality of life index (DLQI) score of psoriasis were obtained after 8 weeks of treatment. There was significant positive correlation between DLQI score and PASI score in group P0.053.There was significant positive correlation between the improvement rate of DLQI score and the improvement rate of PASI score. There was significant difference in the total effective rate between the high dose group and the other two groups. The total effective rate of medium dose group was significantly different from that of small dose group (蠂 ~ 2 / 2 ~ (9.14)) P _ (0.05). The radiation frequency and total dose of high dose group were less than those of medium dose group and small dose group. The total effective rate of high dose group was lower than that of medium dose group and small dose group. The total effective rate of high dose group was lower than that of medium dose group and small dose group. The satisfaction score after treatment was higher than that in the low dose group (P 0.05), and the radiation frequency and the total dose in the medium dose group were lower than those in the small dose group. There was a significant difference in the recurrence rate between the high dose and middle dose groups and the small dose group (蠂 2 10. 58% 7.64% P 0. 05). Conclusion High dose 308nm excimer light therapy is more effective than low dose 308nm excimer light therapy, and it can treat small and stubborn skin lesions with a total area. High dose irradiation can be selected.
【作者單位】： 西南醫(yī)科大學臨床醫(yī)學院;重慶三峽醫(yī)藥高等�？茖W校附屬醫(yī)院皮膚科;重慶市第一人民醫(yī)院皮膚科;
【基金】：基金項目:重慶三峽醫(yī)藥高等專科學校2015-2016年度苗圃工程(2016mpxz13)
【分類號】：R758.63

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