本文選題：阿維A　切入點：雷公藤多甙　出處：《吉林大學(xué)》2012年碩士論文

【摘要】：背景：掌跖膿皰病是一種病因尚未完全明了的發(fā)生于掌跖部位的慢性、復(fù)發(fā)性、炎癥性疾病。多數(shù)人認為免疫學(xué)介導(dǎo)的發(fā)病機制在掌跖膿皰病的發(fā)生上起著重要的作用，但也有人認為本病是一種局限性膿皰型銀屑病。本病的典型臨床表現(xiàn)是在紅斑基礎(chǔ)上周期性發(fā)生的深在無菌性小膿皰,伴角化、脫屑。治療方法多樣主要有維甲酸類、免疫抑制劑、生物調(diào)節(jié)劑，，抗生素類以及物理療法，但療效都不十分滿意。阿維A聯(lián)合雷公藤多甙治療掌跖膿皰病的國內(nèi)相關(guān)報道較少。 目的：觀察阿維A聯(lián)合雷公藤多甙治療掌跖膿皰病療效和安全分析。 方法：搜集門診患者102例，隨機分成三組：分別為阿維A聯(lián)合雷公藤多甙組、阿維A組、雷公藤多甙組，同時均外用復(fù)方丙酸氯倍他索軟膏（商品名：金紐爾）療程2月，然后根據(jù)各項治療指標進行比較。 結(jié)果：阿維A聯(lián)合雷公藤多甙組治療2個月后有效率明顯高于另外兩組（阿維A聯(lián)合雷公藤多甙組為92.31%，阿維A組為64.52%，雷公藤多甙組為62.5%），阿維A聯(lián)合雷公藤多甙組與阿維A組相比（X~2=9.092，P=0.0280.05）差異有統(tǒng)計學(xué)意義；阿維A聯(lián)合雷公藤多甙組與雷公藤多甙組相比（X~2=11.084，P=0.0110.05）差異有統(tǒng)計學(xué)意義；阿維A組與雷公藤多甙組相比（X~2=0.575，P=0.902＞0.05)差異無統(tǒng)計學(xué)意義。 結(jié)論：與單用阿維A或者雷公藤多甙相比兩藥聯(lián)合應(yīng)用治療掌跖膿皰病療效高，不良反應(yīng)無明顯增加。
[Abstract]:Background: palmoplantar pustulosis is a chronic, recurrent and inflammatory disease that occurs at palmar and metatarsal sites. Most people believe that immunopathogenesis plays an important role in the development of palmoplantar pustulosis. But some people also think that this disease is a kind of localized pustular psoriasis. The typical clinical manifestation of this disease is that it occurs periodically on the basis of erythema in the aseptic pustules, accompanied by keratosis, desquamation. The main treatment methods are retinoic acid. Immunosuppressants, biological modulators, antibiotics and physiotherapy are not very satisfactory. There are few reports on the treatment of palmoplantar pustulosis with avea combined with tripterygium wilfordii polyglycosides. Objective: to observe the efficacy and safety of avea combined with tripterygium wilfordii polyglycoside in the treatment of palmoplantar pustulosis. Methods: 102 outpatients were randomly divided into three groups: Avera combined with tripterygium wilfordii polyglycosides group, avea group, tripterygium wilfordii polyglycoside group, and were treated with compound clobetasol propionate ointment for 2 months. Then according to the treatment indicators were compared. Results: after 2 months treatment, the effective rate of avea combined with tripterygium wilfordii polyglycoside group was significantly higher than that of the other two groups (92.31% in the avea combined with tripterygium wilfordii polyglycoside group, 64.52% in the avea group, 62.5% in the tripterygium wilfordii polyglycoside group). There was significant difference between group A and group A (P 0.0280.05). There was no significant difference between Avera and Tripterygium wilfordii polyglycosides group and Tripterygium wilfordii polyglycoside group compared with tripterygium wilfordii polyglycoside group (P < 0.01), but there was no significant difference between Avera group and Tripterygium wilfordii polyglycoside group (P < 0.05). Conclusion: compared with Avera or Tripterygium wilfordii polyglycosides alone, the combined treatment of palmoplantar pustulosis is more effective than that of tripterygium wilfordii.
【學(xué)位授予單位】：吉林大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2012
【分類號】：R753

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