發(fā)布時間：2018-03-26 09:05

  本文選題：銀屑病　切入點(diǎn)：內(nèi)皮細(xì)胞特異性分子　出處：《臨床皮膚科雜志》2017年04期

【摘要】：目的 :探究窄譜中波紫外線(NB-UVB)光療后尋常性銀屑病患者外周血中性粒細(xì)胞與淋巴細(xì)胞比值(NLR)、血清內(nèi)皮細(xì)胞特異性分子及nesfatin-1水平。方法:共選取100例研究對象,其中患者組選取銀屑病患者52例,對照組選取健康志愿者48例�；颊呓MNB-UVB光療3個月后,計算患者組皮損面積及嚴(yán)重程度指數(shù)(PASI)。測定患者組治療前、后和對照組的NLR、血清內(nèi)皮細(xì)胞特異性分子及nesfatin-1水平。結(jié)果 :光療3個月后,患者組臨床有效率為92.3%。與治療前相比,患者組治療后皮損PASI評分顯著減低,差異具有統(tǒng)計學(xué)意義(P0.05)。與對照組相比,治療前患者組中性粒細(xì)胞計數(shù)、NLR顯著增高(P0.05)。同時,治療前患者組血清內(nèi)皮細(xì)胞特異性分子水平與疾病嚴(yán)重程度呈顯著相關(guān)性�；颊呓M患者NB-UVB光療前、后,NLR、血清內(nèi)皮細(xì)胞特異性分子及nesfatin-1水平存在顯著差異,其中NLR和血清內(nèi)皮細(xì)胞特異性分子顯著降低,nesfatin-1水平顯著增高(P0.05)。結(jié)論:NB-UVB光療治療尋常性銀屑病臨床療效顯著,上述3個指標(biāo)水平存在顯著差異,因此,三者能夠反映尋常性銀屑病患者光療臨床療效,具有一定臨床意義。
[Abstract]:Objective: to investigate the ratio of neutrophils to lymphocytes in peripheral blood of patients with psoriasis vulgaris after phototherapy with NB-UVB in narrow band ultraviolet B (UVB). Methods: the levels of serum endothelial cell specific molecules and nesfatin-1 were studied in 100 patients with psoriasis vulgaris. 52 patients with psoriasis and 48 healthy volunteers were selected in the patient group. After 3 months of NB-UVB phototherapy, the skin lesion area and severity index of the patient group were calculated. Results: after 3 months of phototherapy, the clinical effective rate of the patient group was 92.3g. Compared with before treatment, the PASI score of the skin lesion in the patient group was significantly lower than that before treatment. The difference was statistically significant (P 0.05). Compared with the control group, the neutrophil count and NLR in the patients before treatment were significantly higher than those in the control group. The level of serum endothelial cell specific molecule was significantly correlated with the severity of the disease in patients before and after NB-UVB phototherapy, and there were significant differences in the levels of serum endothelial cell specific molecules and nesfatin-1 before and after phototherapy. Among them, NLR and serum endothelial cell specific molecules significantly decreased the level of fennesfatin-1 and increased the level of P0.05.Conclusion the clinical efficacy of the phototherapy of 10% NB-UVB in the treatment of psoriasis vulgaris is remarkable, and there are significant differences among the above three indexes. They can reflect the clinical effect of phototherapy in psoriasis vulgaris and have certain clinical significance.
【作者單位】： 延安大學(xué)附屬醫(yī)院皮膚科;西安交通大學(xué)第二附屬醫(yī)院皮膚科;
【分類號】：R758.63
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本文編號：1667235