發(fā)布時間：2018-03-24 21:44

  本文選題：銀屑病　切入點：腸粘膜通透性　出處：《蘭州大學》2010年碩士論文

【摘要】： 第一部分進行期銀屑病患者腸粘膜通透性變化的研究 目的：研究銀屑病患者腸粘膜通透性的變化,探討銀屑病的發(fā)病機制。 方法：進行期尋常型銀屑病患者40例,口服測試液50ml(含乳果糖10g、甘露醇5g),留取6h內全部尿液,用高效液相色譜法測定尿中乳果糖(L)與甘露醇(M)濃度,計算二者的比值(L／M),同時測定患者皮損基本消退后的L/M值。以20例健康成人作為對照。 結果：銀屑病患者組L／M比值為0.070±0.026,顯著高于正常對照組(0.029±0.006)及同組患者治愈后(0.036±0.009)(P0.05)。 結論：進行期尋常型銀屑病患者腸粘膜通透性較正常人及皮損消退后患者增高,可能與銀屑病的發(fā)生及發(fā)展有關。 第二部分銀屑病患者病情與飲食相關性的研究 目的：探討影響銀屑病病情的飲食因素及其他相關因素。 方法：采用問卷調查表,應用1：l配比病例對照研究,共調查200例尋常型銀屑病患者的飲食及其他病情相關因素。使用單因素logistic回歸分析結合多因素條件logist ic回歸模型分析。 結果：面粉(OR=2.214)、牛肉(OR=3.308)、羊肉(OR=2.145)、魚蝦(OR=1.952)、辣椒(OR=2.559)、洋蔥(OR=1.519)、吸煙(OR=2.515)、飲酒(OR=2.205)、肥胖(OR=1.557)、咸菜酸菜(OR=1.752)是銀屑病發(fā)病的可能危險因素。經(jīng)常食用大米(OR=0.422)、粗糧(OR=0.252)、蛋類(OR=0.459)、鮮奶(OR=0.576)、蘋果(OR=0.650)、香蕉(OR=0.656)、芹菜(OR=0.515)、茄子(OR=0.652)可能是銀屑病發(fā)病的保護因素。 結論：吸煙、嗜酒、魚蝦、羊肉、牛肉、辣椒、面粉、肥胖、洋蔥、咸菜酸菜可作為獨立危險因素,對銀屑病的發(fā)病有一定的影響。大米、粗糧、雞蛋、鮮奶、蘋果、香蕉、芹菜、茄子可能對銀屑病的發(fā)病起保護作用。
[Abstract]:Part one study on the changes of intestinal mucosal permeability in patients with psoriasis. Objective: to study the changes of intestinal mucosal permeability in patients with psoriasis and explore the pathogenesis of psoriasis. Methods: in 40 patients with psoriasis vulgaris, the concentrations of lactulose 10 g and mannitol 5 g / L were determined by high performance liquid chromatography (HPLC). The ratio of the two was calculated and the L / M value of the patients after the skin lesions had basically subsided was measured. 20 healthy adults were used as the control. Results: the ratio of L / M in psoriatic patients was 0.070 鹵0.026, which was significantly higher than that in normal controls (0.029 鹵0.006) and in the same group (0.036 鹵0.009). Conclusion: the intestinal mucosal permeability in the patients with psoriasis vulgaris is higher than that in the normal subjects and the patients whose lesions have subsided, which may be related to the occurrence and development of psoriasis. The second part of the study on the relationship between the status of psoriasis and diet. Objective: to explore the dietary factors and other related factors affecting the condition of psoriasis. Methods: a 1: 1 matched case-control study was conducted to investigate the dietary and other related factors of 200 patients with psoriasis vulgaris. Univariate logistic regression analysis combined with multivariate conditional logist regression model was used. The results showed that the possible risk factors of the disease were: flour or 2.214g, beef order 3.308m, lamb chestnut 2.145m, fish and shrimps 1.952m, chilli 2.559m, onion Onion OR1.519g, smoking OR2.2515, drinking alcohol 2.20555, obesity OR1.5577, saltwater pickled vegetables OR1.752), regular consumption of rice and ornion 0.42222, coarse grain OR0.252, eggs 0.459, fresh milk 0.576o.0.576o.0.576o.0.576A, 0.576A, 0.576g, 0.576A, 0.576g, 0.576g, 0.576g, 0.576g, 0.576g, 0.576g, 0.576g, 0.576g, 0.576g, 0.576m, 0.576m, 0.576g / kg, 0.50,0.50,0.50,0.50,0.650respectively. The protective factors of psoriasis may be plantain Orchus 0.656, celery Orchus 0.515, eggplant Orchus 0.652), which may be the protective factor of psoriasis. Conclusion: smoking, alcoholism, fish and shrimp, mutton, beef, pepper, flour, obesity, onion, pickle and pickle can be independent risk factors for psoriasis. Celery and eggplant may play a protective role in the pathogenesis of psoriasis.
【學位授予單位】：蘭州大學
【學位級別】：碩士
【學位授予年份】：2010
【分類號】：R758.63

【引證文獻】

相關碩士學位論文 前1條

1 曲善忠;中藥復方治療尋常型銀屑病的臨床療效觀察及其尿液代謝組學研究[D];廣州中醫(yī)藥大學;2012年

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本文編號：1660187