本文選題：癡呆　切入點：神經(jīng)梅毒　出處：《蘇州大學(xué)》2011年碩士論文

【摘要】：目的:探討以癡呆為突出表現(xiàn)的神經(jīng)梅毒的臨床特征及其治療和預(yù)后,以提高對該病的診治水平。 方法:結(jié)合檢索Medline和中國生物醫(yī)學(xué)文獻數(shù)據(jù)庫(CBM),對1989年至今(2010年)國內(nèi)外文獻中公開發(fā)表的(病例報告形式)以癡呆為突出表現(xiàn)的梅毒患者的病歷資料進行回顧性分析。 結(jié)果:納入43篇文獻共60例患者(59例麻痹性癡呆及1例梅毒性精神神經(jīng)病),其臨床特征包括:①男性多見;②多數(shù)隱匿起病;③首發(fā)癥狀以記憶力減退和性格改變多見;④MRI、CT以腦萎縮為主;⑤血和CSF的梅毒抗體檢查陽性,也可有特殊情況;⑥確診較困難;⑦驅(qū)梅治療近期癥狀可不同程度改善;⑧缺乏遠期療效的隨訪資料。 結(jié)論:①麻痹性癡呆和梅毒性精神神經(jīng)病均可有癡呆表現(xiàn);②原因不明的癡呆患者應(yīng)常規(guī)行梅毒血清學(xué)及腦脊液檢查;③驅(qū)梅結(jié)合對癥治療大多近期療效好,發(fā)生腦萎縮者預(yù)后較差;④需長期隨訪觀察其遠期療效。
[Abstract]:Objective: To investigate the clinical characteristics of neurosyphilis typically manifested by dementia and its treatment and prognosis, in order to improve the level of diagnosis and treatment of the disease.
Methods: combined with the retrieval of Medline and the Chinese biomedical literature database (CBM), we retrospectively analyzed the medical records of syphilis patients with dementia manifested by dementia (published in 1989 and 2010).
Results: 43 articles were included in a total of 60 cases of patients (59 cases of paralytic dementia and 1 cases of syphilitic psychoneurosis), including its clinical features: male; the most insidious onset; first symptoms with memory impairment and personality changes; the MRI, CT in cerebral atrophy; syphilis antibody test the blood and CSF positive, also can have the special circumstances; the diagnosis is difficult; the treatment of syphilis symptom can be improved; the lack of follow-up data of long-term curative effect.
Conclusion: both the paralytic dementia and syphilitic psychoneurosis with dementia; dementia of the patients with unknown causes should be routine syphilis serum and cerebrospinal fluid examinations; the syphilis and symptomatic treatments mostly good curative effect, the occurrence of cerebral atrophy is associated with a poor prognosis; the need for long-term follow-up to observe the long-term curative effect.

【學(xué)位授予單位】：蘇州大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2011
【分類號】：R759.1

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