本文關(guān)鍵詞： IL- 炎癥 皮膚 綜述　出處：《細(xì)胞與分子免疫學(xué)雜志》2014年09期 　論文類(lèi)型：期刊論文

【摘要】：IL-33是IL-1細(xì)胞因子超家族的成員,組成性的表達(dá)于多種人類(lèi)組織的細(xì)胞上,在皮膚組織細(xì)胞上呈現(xiàn)高表達(dá)。IL-33的特異性受體是轉(zhuǎn)硫酶同系物(ST2),主要表達(dá)在Th2細(xì)胞、肥大細(xì)胞、巨噬細(xì)胞、樹(shù)突狀細(xì)胞、NK細(xì)胞和自然殺傷性T細(xì)胞等免疫細(xì)胞表面。IL-33的經(jīng)典信號(hào)途徑是通過(guò)ST2配體(ST2L)和IL-1受體輔助蛋白(IL-1RAP)組成的異二聚體,將信號(hào)轉(zhuǎn)導(dǎo)至細(xì)胞內(nèi)。IL-33是一種雙效型的細(xì)胞因子,與皮膚多種炎癥性疾病密切相關(guān),尤其是銀屑病和特應(yīng)性皮炎,本文對(duì)IL-33及其在皮膚相關(guān)炎癥性疾病的研究進(jìn)展進(jìn)行了綜述。
[Abstract]:IL-33 is a member of the IL-1 cytokine superfamily, which is constitutively expressed in a variety of human tissue cells. The specific receptor for high expression of IL-33 in skin tissue cells is the S-transferase homologue ST2, which is mainly expressed in Th2 cells and mast cells. The classic signaling pathway of IL-33 on the surface of immune cells, such as macrophages, dendritic cells, NK cells and natural killer T cells, is the heterodimer composed of ST2 ligand ST2L) and IL-1 receptor helper protein IL-1RAP. The signal transduction to intracellular. IL-33 is a double acting cytokine, which is closely related to many inflammatory diseases of skin, especially psoriasis and atopic dermatitis. This article reviews the research progress of IL-33 and its role in skin related inflammatory diseases.
【作者單位】： 新鄉(xiāng)醫(yī)學(xué)院基礎(chǔ)醫(yī)學(xué)院免疫學(xué)教研室;新鄉(xiāng)醫(yī)學(xué)院第一附屬醫(yī)院皮膚科;
【基金】：河南省科技廳科技攻關(guān)項(xiàng)目(114300510012) 新鄉(xiāng)醫(yī)學(xué)院博士啟動(dòng)基金(BSQD2013008)
【分類(lèi)號(hào)】：R751
，

本文編號(hào)：1538421