本文關(guān)鍵詞：阿維A與氨甲蝶呤治療重度斑塊型銀屑病的療效　出處：《中南大學(xué)學(xué)報(醫(yī)學(xué)版)》2016年08期 　論文類型：期刊論文

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【摘要】：目的:觀察阿維A與氨甲蝶呤治療重度斑塊型銀屑病的療效。方法:54例確診為斑塊型銀屑病的患者被分為阿維A組(32例,口服阿維A30 mg,每日1次)和氨甲蝶呤組(22例,口服氨甲蝶呤15 mg,每周1次),均外用卡泊三醇軟膏和硼酸軟膏,療程8周。以銀屑病面積和嚴(yán)重度指數(shù)(psoriasis area and severity index,PASI)作為觀察指標(biāo),比較兩種藥物的療效。結(jié)果:治療后,阿維A組和氨甲蝶呤組PASI評分均較治療前下降(P0.001),PASI評分改善率和PASI評分有效率在兩組間比較差異均無統(tǒng)計學(xué)意義(均P0.05)。結(jié)論:阿維A或氨甲蝶呤治療重度斑塊型銀屑病均有效,且療效相當(dāng)。
[Abstract]:Objective: to observe the efficacy of Avera and methotrexate in the treatment of severe plaque psoriasis. Methods: Fifty-four patients with severe plaque psoriasis were divided into two groups: group A (n = 32) and group A (n = 32). Methotrexate group (n = 22) and methotrexate group (n = 22) were treated with carpotriol ointment and boric acid ointment by oral methotrexate 15 mg once a week. The psoriasis area and severity index (PASI) was used as the index of psoriasis area and severity. Results: after treatment, the PASI scores in group A and group A were significantly lower than those before treatment (P 0.001). There was no significant difference in the improvement rate of PASI score and the effective rate of PASI score between the two groups (all P0.050.Conclusion: Avera or methotrexate are effective in the treatment of severe plaque psoriasis. And the curative effect is similar.
【作者單位】： 中南大學(xué)湘雅醫(yī)院皮膚科;
【基金】：湖南省財政廳湖南衛(wèi)生項目(2100201) 湖南省科技廳科技計劃項目(2013FJ6004)~~
【分類號】：R758.63
【正文快照】： 第一作者(First author):劉盼盼,Email:liupanpan91@hotmail.com斑塊型銀屑病是以紅斑、鱗屑、浸潤為改變的慢性炎癥性皮膚病,近年來該病在我國的發(fā)病率呈上升趨勢[1],其反復(fù)發(fā)作的特點嚴(yán)重影響著患者的身心健康[2]。阿維A和氨甲蝶呤均為治療重度斑塊型銀屑病的一線用藥[3],但

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