【摘要】：目的分析非酮癥糖尿病患者糖化血紅蛋白(HbA_(1c))與紅細(xì)胞分布寬度變異系數(shù)(RDW-CV)和甲狀腺過氧化物酶抗體(TPOAb)陽性率的相關(guān)性,并探討HbA_(1c)變化的影響因素。方法選取2014年3月—2016年4月在益陽市中心醫(yī)院內(nèi)分泌科住院的符合納入標(biāo)準(zhǔn)的非酮癥糖尿病患者413例。依據(jù)患者HbA_(1c)進(jìn)行分組:HbA_(1c)≤7.5%組(A組,n=128)、7.5%HbA_(1c)10.0%組(B組,n=190)、HbA_(1c)≥10.0%組(C組,n=95)。比較3組患者性別、年齡、病程、體質(zhì)指數(shù)(BMI)、RDW-CV、低密度脂蛋白(LDL)、總膽固醇(TC)、24 h尿微量清蛋白(24 h UAE)、C反應(yīng)蛋白(CRP)、空腹C肽(FCP)、餐后2 h C肽(PCP)、游離三碘甲狀腺原氨酸(FT3)、游離甲狀腺素(FT4)、促甲狀腺激素(TSH)、谷氨酸脫羥酶抗體(GADA)陽性率、TPOAb陽性率,分析HbA_(1c)與上述指標(biāo)的相關(guān)性及影響患者HbA_(1c)變化的獨(dú)立危險(xiǎn)因素。結(jié)果 B組、C組患者病程長于A組,RDW-CV大于A組,TSH及TPOAb陽性率高于A組(P0.05);C組患者病程長于B組,RDW-CV大于B組,TSH、TPOAb陽性率高于B組(P0.05)。Spearman秩相關(guān)分析結(jié)果顯示,患者HbA_(1c)與病程、RDW-CV、TPOAb陽性率、TSH呈正相關(guān)(rs值分別為0.681、0.630、0.432、0.438,P值分別為0.001、0.001、0.001、0.001)。RDW-CV[OR=2.024,95%CI(1.237,4.103)]、TPOAb陽性率[OR=1.243,95%CI(1.134,1.548)]、TSH[OR=1.814,95%CI(1.567,3.234)]是非酮癥糖尿病患者HbA_(1c)變化的獨(dú)立危險(xiǎn)因素(P0.05)。結(jié)論非酮癥糖尿病患者HbA_(1c)與RDW-CV、TPOAb陽性率呈正相關(guān),且RDW-CV、TPOAb陽性率是患者HbA_(1c)變化的獨(dú)立危險(xiǎn)因素,因此,血糖控制越差,紅細(xì)胞形態(tài)改變越明顯,免疫性甲狀腺疾病發(fā)生的可能性越大。
[Abstract]:Objective to analyze the correlation between glycosylated hemoglobin (HbA_ 1c) and the coefficient of variation of erythrocyte distribution width (RDW-CV) and the positive rate of thyroid peroxide antibody (TPOAb) in patients with non-ketosis diabetes mellitus, and to explore the influencing factors of the change of HbA_ (1c). Methods 413 patients with non-ketosis diabetes who met the inclusion criteria were selected from March 2014 to April 2016 in Endocrinology Department of Yiyang Central Hospital. The patients were divided into two groups according to HbA_ (1c): HbA_ (1c) 鈮，

本文編號：2519853